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The map label for this gene is vanR [H]

Identifier: 118478544

GI number: 118478544

Start: 3095653

End: 3096357

Strand: Reverse

Name: vanR [H]

Synonym: BALH_2920

Alternate gene names: 118478544

Gene position: 3096357-3095653 (Counterclockwise)

Preceding gene: 118478545

Following gene: 118478543

Centisome position: 58.9

GC content: 39.01

Gene sequence:

>705_bases
TTGGTAATCATGAGTGATAAAGTACTTATTGTGGAAGATGAACGTGAAATTGCCGATTTGGTTGAGCTATACTTGAAAAA
CGAGAATTATACGGTTTTCAAATATTATACTGCTAAAGAAGCGTTGGAATGTATAGACAAGAATGCGATTGACCTTGCAA
TATTGGACATTATGCTTCCCGACGTAAGTGGTCTCACTATCTGTCAAAAAATAAGGGAAAAGCATACCTATCCAATTATC
ATGTTGACAGCGAAAGATACAGAAGTAGATAAAATTACTGGGCTAACAATTGGCGCGGATGATTATATTACAAAGCCTTT
TCGTCCACTAGAGTTAATTGCGCGAGTCAAAGCGCAGTTACGCCGGTATAAAAAATACAATGGAGTAACGGCACAGAACG
AGAATGTTATCGTCCACTCTGGTCTTGTTATTAATATAAGCACGCATGAGTGTTCTCTGAACGAGAAACCGTTATCTCTC
ACTCCCACCGAGTTTTCAATCCTGCGTATCCTCTGTGAAAACAAGGGAAATGTGGTTAGCTCTGAGCAGCTGTTTCATGA
GATATGGGGTGACGAATATTTCAGCAAGAGTAATAACACTATCACCGTGCATATCCGACATCTGCGAGAAAAGATGAACG
ACACGGTTGATAATCCGAAATATATAAAAACGGTATGGGGGATCGGCTATAAAATTGAAAAATAA

Upstream 100 bases:

>100_bases
GTCTGTATACAGCAATATGACTTTACTTGGTGTAATAGGTATGATAGGCTCGTTATTCAGAAAAGATTCCGATTGAGAAA
AGCACATCCATAAAGGAGGA

Downstream 100 bases:

>100_bases
AAATAAGAATAAAAAAATCGATTATTCAAAATTAAAACGGAAACTCTACCAATATATCCTTACGATTGTTATGGCAGCAG
TTGTATTTGTGCTGTTTTTA

Product: vancomycin response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MVIMSDKVLIVEDEREIADLVELYLKNENYTVFKYYTAKEALECIDKNAIDLAILDIMLPDVSGLTICQKIREKHTYPII
MLTAKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQLRRYKKYNGVTAQNENVIVHSGLVINISTHECSLNEKPLSL
TPTEFSILRILCENKGNVVSSEQLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTVDNPKYIKTVWGIGYKIEK

Sequences:

>Translated_234_residues
MVIMSDKVLIVEDEREIADLVELYLKNENYTVFKYYTAKEALECIDKNAIDLAILDIMLPDVSGLTICQKIREKHTYPII
MLTAKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQLRRYKKYNGVTAQNENVIVHSGLVINISTHECSLNEKPLSL
TPTEFSILRILCENKGNVVSSEQLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTVDNPKYIKTVWGIGYKIEK
>Mature_234_residues
MVIMSDKVLIVEDEREIADLVELYLKNENYTVFKYYTAKEALECIDKNAIDLAILDIMLPDVSGLTICQKIREKHTYPII
MLTAKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQLRRYKKYNGVTAQNENVIVHSGLVINISTHECSLNEKPLSL
TPTEFSILRILCENKGNVVSSEQLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTVDNPKYIKTVWGIGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=38.9380530973451, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=38.4279475982533, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=35.7758620689655, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=35.4978354978355, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=36.6812227074236, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=34.9557522123894, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=31.4410480349345, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=33.0472103004292, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=32.8947368421053, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=32.7014218009479, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=33.7719298245614, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=31.4410480349345, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26911; Mature: 26911

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIMSDKVLIVEDEREIADLVELYLKNENYTVFKYYTAKEALECIDKNAIDLAILDIMLP
CEEECCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCHHEEEEEECCC
DVSGLTICQKIREKHTYPIIMLTAKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQL
CCCCHHHHHHHHHCCCCEEEEEEECCCCCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RRYKKYNGVTAQNENVIVHSGLVINISTHECSLNEKPLSLTPTEFSILRILCENKGNVVS
HHHHHHCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCCEEH
SEQLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTVDNPKYIKTVWGIGYKIEK
HHHHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEEECC
>Mature Secondary Structure
MVIMSDKVLIVEDEREIADLVELYLKNENYTVFKYYTAKEALECIDKNAIDLAILDIMLP
CEEECCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCHHEEEEEECCC
DVSGLTICQKIREKHTYPIIMLTAKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQL
CCCCHHHHHHHHHCCCCEEEEEEECCCCCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RRYKKYNGVTAQNENVIVHSGLVINISTHECSLNEKPLSLTPTEFSILRILCENKGNVVS
HHHHHHCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCCEEH
SEQLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTVDNPKYIKTVWGIGYKIEK
HHHHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]