Click here to switch to the map view.

The map label for this gene is kdc [H]

Identifier: 118477879

GI number: 118477879

Start: 2380696

End: 2381220

Strand: Reverse

Name: kdc [H]

Synonym: BALH_2224

Alternate gene names: 118477879

Gene position: 2381220-2380696 (Counterclockwise)

Preceding gene: 118477880

Following gene: 118477873

Centisome position: 45.3

GC content: 37.14

Gene sequence:

>525_bases
TTGCAGAGCAAGGAACACCTTTCTTTGGTAGTGCCGGCCGCTATCCCTTTACCAAACAACACTACATATGTAGCGCAACC
ATTACGGGGATCGATCGGCTATACATTACCTGCTCTACTTGGTACACAGCTCGCTAATTTATCACGGCGCAACATTTTAA
TTATTGGTGATGGTTCTTTCCAATTAACTGTCCAAGAGTTATCGACCATACTTCGTCAAAATTTAAAACCGATTATATTT
TTAATTAATAACAATGGTTATACTGTTGAACGTGCAATTCATGGTCAAATTGAACCATATAATGACAAACAAATGTGGGA
GTACACAAAACTAGCGAACGTAGTTGGAACAGAAGAAAAAAGCCAAACATTTAAAGTAGAAAATGAAACAGAGTTACAAG
AAGTCTTAACTAAAATAAGTATTGATAAGGATCAACTTACCTTTGTTGAAGTTGTAATGAGCCAAGGGGATCAGCCTGAA
TTGTTAGTTAAACTTGGGAAGAGATTCGGCCAGCAAAATGCTTAA

Upstream 100 bases:

>100_bases
CTATTAATTACTGAAAAGTTTAATCCAAAGCTACAAATGGTTACACAAAAACGCTTTTGGCAGCAAATGTACCATTTCTT
ACAGGAAAACGACGTCTTAA

Downstream 100 bases:

>100_bases
AAAGAAAAGCGTAACCTATATATAGTTACGCTTTTCTTTTTAAATTTTTATTCAGCAAGCGTTAACTGCCAAGACACACC
ATACTTATCATTTAACCAAC

Product: indolepyruvate decarboxylase, C-terminal

Products: 2-(indol-3-yl)acetaldehyde; CO2

Alternate protein names: KDC [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MQSKEHLSLVVPAAIPLPNNTTYVAQPLRGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLKPIIF
LINNNGYTVERAIHGQIEPYNDKQMWEYTKLANVVGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPE
LLVKLGKRFGQQNA

Sequences:

>Translated_174_residues
MQSKEHLSLVVPAAIPLPNNTTYVAQPLRGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLKPIIF
LINNNGYTVERAIHGQIEPYNDKQMWEYTKLANVVGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPE
LLVKLGKRFGQQNA
>Mature_174_residues
MQSKEHLSLVVPAAIPLPNNTTYVAQPLRGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLKPIIF
LINNNGYTVERAIHGQIEPYNDKQMWEYTKLANVVGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPE
LLVKLGKRFGQQNA

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes [H]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323073, Length=163, Percent_Identity=39.2638036809816, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323163, Length=167, Percent_Identity=40.1197604790419, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321524, Length=163, Percent_Identity=37.4233128834356, Blast_Score=107, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320123, Length=159, Percent_Identity=36.4779874213836, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320588, Length=166, Percent_Identity=34.3373493975904, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: 4.1.1.74

Molecular weight: Translated: 19509; Mature: 19509

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSKEHLSLVVPAAIPLPNNTTYVAQPLRGSIGYTLPALLGTQLANLSRRNILIIGDGSF
CCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCE
QLTVQELSTILRQNLKPIIFLINNNGYTVERAIHGQIEPYNDKQMWEYTKLANVVGTEEK
EEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
SQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLVKLGKRFGQQNA
CCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQSKEHLSLVVPAAIPLPNNTTYVAQPLRGSIGYTLPALLGTQLANLSRRNILIIGDGSF
CCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCE
QLTVQELSTILRQNLKPIIFLINNNGYTVERAIHGQIEPYNDKQMWEYTKLANVVGTEEK
EEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
SQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLVKLGKRFGQQNA
CCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-(indol-3-yl)pyruvate

Specific reaction: 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA