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The map label for this gene is hisC1 [H]

Identifier: 118477071

GI number: 118477071

Start: 1513585

End: 1514715

Strand: Direct

Name: hisC1 [H]

Synonym: BALH_1372

Alternate gene names: 118477071

Gene position: 1513585-1514715 (Clockwise)

Preceding gene: 118477070

Following gene: 118477072

Centisome position: 28.79

GC content: 36.69

Gene sequence:

>1131_bases
ATGACTGGGGGAAGAAAAATGAGAGTGAAAGAGCAATTGTTAACTTTGAGAGCATATGTACCTGGGAAAAATATTGAAGA
AGTCAAAAGGGAATATGGGTTATCGAAAATTGTGAAATTGGCATCGAACGAAAATCCGTTCGGTTGCTCAGCACGCGTAA
CAGAAGCATTAACTTCTTTAGCGAGTCAATACGCTCTTTATCCAGATGGACATGCCTTTGAACTTCGAACACAAGTAGCA
AAACATTTAGGTGTTAAAGCGGAACAACTGTTATTTGGTAGTGGATTAGATGAAGTTATTCAAATGATTAGTCGTGCGTT
ACTACACGAAGGAACAAATGTTGTAATGGCGAATCCAACATTCTCGCAATACCATCACCATGCTGTTATTGAAGGAGCAG
AAGTTCGTGAAGTATCACTTAAAGATGGCATTCACGATTTAGATGCGATGTTACAGCAAGTAGATGATCAAACGAAGATT
GTATGGATTTGTAACCCGAATAATCCGACAGGTACATATGTAGAAAAACAAAAATTACTTTCATTTTTAGAATCAGTTCC
TAAGTCAGCGCTTGTTATTATGGACGAAGCATATTATGAATACGCGGGAGCAGAAGACTATCCGCGAACATTACCACTTC
TTGAAAAGTATGAAAATCTTATGGTATTACGTACGTTTTCAAAAGCATATGGTCTAGCTGCTTTCCGTATCGGATACGCA
GTTGGTAATACGGAGTTAATCGGGCAGCTAGAAGTAGCGAGGTTACCATTTAATACATCGACTGTAGCGCAATCTGTAGC
ACTAGCTGCATTAGAAGATCAAGCATTTTTACAAGAATGTGTGAAAAAGAATGAAGAAGGATTACATCAATATTACGCAT
TTTGTAAGGAATATAACGTATTCTATTATCCATCTCAAACAAATTTCATTTTCTTAAAACTCGGTATTCCTGGTAATGAA
GCTTTCGAACGATTAATGAAAAAAGGATATATTGTTCGTTCTGGTGCTGCATTTGGTATCGATGATGGCATTCGTATTAC
TGTCGGTTTGAAAGAAGAAAATGATGAAATTATAGAGTTACTGAAAGAACTTGTAAATGAGCAAGTACAGAAAGAGGAAA
CATATTCTTAA

Upstream 100 bases:

>100_bases
GCCATGAAGTGCTTATTTTGAGGTGTTTTCGTAATAGTGACGGTTAGGATAAAAGATTACAGTAAAGGGCTAAAATTGTA
TTGTAATCGAATTCAATAAA

Downstream 100 bases:

>100_bases
GAGATTGTGAAGGCTCCTATTAGAGGAGTCTTTTTTATCGCATTAAAAAAGTTGAAGTTTGGTAATTAAGTTGTTCTGTA
AATTACGATTTGTATGGCTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTGGRKMRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVA
KHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKI
VWICNPNNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPRTLPLLEKYENLMVLRTFSKAYGLAAFRIGYA
VGNTELIGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNE
AFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Sequences:

>Translated_376_residues
MTGGRKMRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVA
KHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKI
VWICNPNNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPRTLPLLEKYENLMVLRTFSKAYGLAAFRIGYA
VGNTELIGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNE
AFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS
>Mature_375_residues
TGGRKMRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAK
HLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIV
WICNPNNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPRTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAV
GNTELIGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEA
FERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=340, Percent_Identity=30, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788722, Length=367, Percent_Identity=25.8855585831063, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788627, Length=239, Percent_Identity=25.1046025104602, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=333, Percent_Identity=30.03003003003, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42262; Mature: 42131

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGRKMRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSL
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHH
ASQYALYPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPT
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCC
FSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLL
HHHHHCHHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHH
SFLESVPKSALVIMDEAYYEYAGAEDYPRTLPLLEKYENLMVLRTFSKAYGLAAFRIGYA
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VGNTELIGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNV
ECCCHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCE
FYYPSQTNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIEL
EEECCCCCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHH
LKELVNEQVQKEETYS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGGRKMRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSL
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHH
ASQYALYPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPT
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCC
FSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLL
HHHHHCHHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHH
SFLESVPKSALVIMDEAYYEYAGAEDYPRTLPLLEKYENLMVLRTFSKAYGLAAFRIGYA
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VGNTELIGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNV
ECCCHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCE
FYYPSQTNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIEL
EEECCCCCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHH
LKELVNEQVQKEETYS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]