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The map label for this gene is lldP [H]

Identifier: 118476815

GI number: 118476815

Start: 1249251

End: 1250750

Strand: Direct

Name: lldP [H]

Synonym: BALH_1102

Alternate gene names: 118476815

Gene position: 1249251-1250750 (Clockwise)

Preceding gene: 118476814

Following gene: 118476816

Centisome position: 23.76

GC content: 36.6

Gene sequence:

>1500_bases
ATGGCCATATTGTTGGCACTTATCCCAATTATGATGATTTTCATTTGTTTATTTTTATTTAAACAAACGTCATTAAGATC
CTCGTTAATTTCTTATGCGGTATGTGTTGGAATCGTTTTACTCTCGCCAACGTTTCAATTAGGGATAAGTGAAACTGTGC
ACGCAACGATTAAAGGATGGTTAATTTGTTTTATTGTCGGGTACGTTTTATTTTTCGGTATTTTTTTATTTCACCTCATG
AACAAAATGGGGTACATCGACCAAGTAGCACGTTTTTTAGAAGAAGTGACGCACGATCGTTTATTACAAATGCTTCTTAT
GTGTTTTGGTATTTGCCCACTAATTGAATCAGTAAGTGGATTTGGAATCGGCTTTATGGTTGCAGCACCTATTTTTCTTT
CATTAGGTTATAAACCGTTTCAAGCTGTACTGCTCTCATTTATCGGCTTACTAGCTAGTTCATGGGGGGCAATGGCAACT
GGTACGATTATCGGTTCCCAGCTTATCAATATGTCGCTTACAACACTCGGTACAAATACAGCGCTATTAAGTATCCCGAT
GTTTGCTTATTTCGTCATTCTTTCTTTACACGTTGTTGGCGGCTGGCAAGCGGTTATTGAAAAGTGGAAGGAAGGATTCG
GTTTCTTTCTATTATTTTCTCTCGGAATCTATCTTTCTAACGCATACGTAAGCGTGGAACTAGCAGGTATATTAAGTTCT
ATCGTTACCATTACATTTGGCTTTCTTATCATTAAAGTAAAAGGAAAAAGTGGGCAAAATCTAATGACAGAACATGCTGC
GGCAACGGAAAGAGAAGTATCTATTATAAAAATTATTAGCCCTTATATATTCTTAACCGTTTGTATTTTACTTTCTCGCC
TCGTACCAGCATTACATGATGTATTTAGATCATATGCGGTTCTTGATTTAAAATCATATTCTTACAAATTAGAAATGCTG
TATTCACCAGGATTTTGGCTCGGTATGACTTGTTTATTTACTATTATTTTCTTCCGCATTCCATCTCATATTATGAAACA
ATCACTCTTACAAACGATAAAACAATGGATTCCGTTCGCTATTACAACGACAATGTTTATTGCTATTTCAGAACTAATGG
GCGCATCTGGCATGCATTCATTACTAGCAAAAACAGCTGGTGAAACATTTGGGACATTTTTCGTTTTCATTGCTCCGTTC
ATCGGTGGGATCGGTGGATTTTTAACAGGTAGTAACGCAGGATCAAATGCGATGTTTATAAAACTACAAATGCAAACGGC
ACAAAATGTAGCACTCCCGTGGCAATACGTCACAACACTGCAAAATACTGCATCATCAGTAGCGACAATTGCTTGCCCAT
CACGGATTACATTAGGTGCGTATTTATGTAACATCCCGTATCGTGAAAATGAACTATTAAAGAAGACGACGTTAATGATT
TTTGGTGCGGTATTACTTATAGTAGTGGAAGTTATTTTCTGGTATATGTTGAGAAATTAA

Upstream 100 bases:

>100_bases
ATACGGCTCTTTTTTGAAACTGTTGTAAAAACAATTGAAAATTATGACATCTGTTATATAATAGTTAAAAATTGTATTTT
AAACGAAATGAGATGATAAC

Downstream 100 bases:

>100_bases
AAATTCTCCTATATTTAGGAGGATTTTTTTTGTTACTGGATAATGCTTTAAATTATGAAAAGCTTCTAATAAATGAATAG
GAGATGAAATGTATGCCCTT

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTHDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMSLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKVKGKSGQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDVFRSYAVLDLKSYSYKLEML
YSPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFIAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLIVVEVIFWYMLRN

Sequences:

>Translated_499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTHDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMSLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKVKGKSGQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDVFRSYAVLDLKSYSYKLEML
YSPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFIAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLIVVEVIFWYMLRN
>Mature_498_residues
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMN
KMGYIDQVARFLEEVTHDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATG
TIIGSQLINMSLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSSI
VTITFGFLIIKVKGKSGQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDVFRSYAVLDLKSYSYKLEMLY
SPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFIAPFI
GGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMIF
GAVLLIVVEVIFWYMLRN

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=539, Percent_Identity=23.191094619666, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790031, Length=512, Percent_Identity=22.65625, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55158; Mature: 55027

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH
LICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEEVTHDRLLQMLLMCFGICPLIESVSG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTIIGSQLINMSLTTLGTNT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCH
ALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
IVTITFGFLIIKVKGKSGQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHD
HHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFRSYAVLDLKSYSYKLEMLYSPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFA
HHHHHHHHEECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFIAPFIGGIGGFLTGSNAGSNAMFI
HHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEE
KLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
EEEECCCCCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHH
FGAVLLIVVEVIFWYMLRN
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]