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The map label for this gene is hemE [H]

Identifier: 118476672

GI number: 118476672

Start: 1090686

End: 1091756

Strand: Direct

Name: hemE [H]

Synonym: BALH_0950

Alternate gene names: 118476672

Gene position: 1090686-1091756 (Clockwise)

Preceding gene: 118476671

Following gene: 118476673

Centisome position: 20.75

GC content: 39.87

Gene sequence:

>1071_bases
GTGGTAAGGAAGGGAGCTAGGGTCTTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTGA
TTATGTGCCAGCATGGTATATGCGTCAAGCAGGTCGTTCGCAGCCGGAATATAGAAAGATAAAAGAAAAGTATTCTTTAT
TTGAAATTACACATAATCCAGAGTTATGTGCTTACGTTACAAAACTACCAGTTGATCAATATAACGTAGACGCAGCAATT
CTTTATAAAGATATTATGTCACCACTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGA
TAATCCAATCCGTTCTTTACAAGACGTAGAAAAACTAGGAGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATA
CAATTCGTTTATTAACGACTGAAATGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTAT
ATGATTGAAGGCGGTCCATCTCGTAACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTTGCTTT
AATGGATAAGCTAGCAGATATGGTTATTACATATTTGAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCG
ATTCTTGGGTTGGAACAGTAAACGTAGCAGATTACCGCGTATTTATTAAACCAGCAATGGAGCGTATTTTTGCAGAAGTT
CGCACGATGGGTGTACCGATGATTATGCACGGCGTAGGAGCTGCCCACTTAGTGAATGAGTGGCACGACTTACCGCTTGA
TGTAGTCGGTTTAGACTGGCGTTTACCAATTGAAGAAGCACGTGCACGCGGCGTTCACAAGGCGGTACAAGGGAATATGG
ATCCGTCATTCTTACTTGCGCCATGGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAGCAGCCA
GGTTATATCTTTAACTTAGGTCACGGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCA
TGAATACTCTAAAGGGCAGTTAGCGAAGTAA

Upstream 100 bases:

>100_bases
GTTTGTGTCAATTTAATGAACAACGTACATAATATTATGCATTTTGTTTTTACAAGCTGTATAGTAAAAAAAGATAAATA
TCGAACGTATTCGAAGCATT

Downstream 100 bases:

>100_bases
AGGAGCATTGCTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATATGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MVRKGARVLVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAI
LYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASY
MIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEV
RTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQP
GYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK

Sequences:

>Translated_356_residues
MVRKGARVLVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAI
LYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASY
MIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEV
RTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQP
GYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
>Mature_356_residues
MVRKGARVLVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAI
LYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASY
MIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEV
RTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQP
GYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=36.2857142857143, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI2367337, Length=345, Percent_Identity=40.2898550724638, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=32.4786324786325, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40093; Mature: 40093

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKGARVLVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCC
ELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLG
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHH
EINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAE
CCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEC
PKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEV
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
RTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLA
HHCCCHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEC
PWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRKGARVLVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCC
ELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLG
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHH
EINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAE
CCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEC
PKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEV
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
RTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLA
HHCCCHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEC
PWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA