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The map label for this gene is proC [H]

Identifier: 118475962

GI number: 118475962

Start: 206638

End: 207441

Strand: Reverse

Name: proC [H]

Synonym: BALH_0197

Alternate gene names: 118475962

Gene position: 207441-206638 (Counterclockwise)

Preceding gene: 118475964

Following gene: 118475961

Centisome position: 3.95

GC content: 40.05

Gene sequence:

>804_bases
ATGCTAACTAAACATCGAATTCTATTTATTGGTGCTGGTCGTATGGCAGAAGCTATATTTTCCGGATTACTTAAAACAAG
CAAAGAATACATCGAAGAGATTATCGTTTCTAACCGAAGTAACGTAGAAAAGCTAGATCAATTACGAGCGCGATATAATG
TGTCTACTACAACAGATTGGAAGCAACATGTTACATCTGTTGATACGATTGTTTTAGCAATGCCGCCTTCTGCACATGAA
GAATTATTAGCAGAGTTATCTCCGTTACTATCGAATCAACTTGTCGTAACGGTAGCTGCTGGCATCGGCCCATCTTATTT
AGAAGAAAGACTTCCCGGGGGGACGCCTGTTGCTTGGATTATGCCAAATACAGCTGCTGAAATTGGAAAGTCTATCTCCT
TATACACGATGGGACAATTCGTAAACGAGACTCATCAAGAAACCCTGCAATTGCTTTTAAGGGGCATTGGTACTTCGCAA
CTTTGTACCGAGGAAGAAGTTCATCAACTTACTGCAGTTACTGGAAGTGCACCAGCCTTCCTTTATTACTTTGCTGAAAG
TTTAATTGAAGCAACAAAAAGTTATGGAGTCGATGAAGCAACCGCCAAACACCTTGTCATTCAAATGATTTCTGGCTCTG
CTTCTATGCTTGAACAAACACAAGATCCAGCTAACCTAAGTGAACAAGTAACAACGCCAGGTGGTTCCACAGCTGAAGGT
CTCAAAGCTTTATATGAATATAATTTTTCACAGGCAATTCAAAAAGCAGTAGAAGCAACAAACAAAAAAGCTAGGGGGAA
ATAA

Upstream 100 bases:

>100_bases
TTATCTATTCCATCTACAATAAGCCTTTTCTTTTTACAAAATTCTCTTAAAAATGGTATCGTTTTTTATAACATATCTCC
ACTAGAAAGGAATAGAGGAT

Downstream 100 bases:

>100_bases
TATGAATTTAACAAGTTTAAAAGACTATACAACATTACATAACGGTGTAAAAATGCCTTGGTTCGGTTTAGGTGTTTTTA
AAGTAGAAGATGGTTCACAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 2; P5CR 2 [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLSEQVTTPGGSTAEG
LKALYEYNFSQAIQKAVEATNKKARGK

Sequences:

>Translated_267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLSEQVTTPGGSTAEG
LKALYEYNFSQAIQKAVEATNKKARGK
>Mature_267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLSEQVTTPGGSTAEG
LKALYEYNFSQAIQKAVEATNKKARGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=262, Percent_Identity=32.824427480916, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=27.8195488721804, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=27.8195488721804, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786585, Length=263, Percent_Identity=28.1368821292776, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=31.1787072243346, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=31.6546762589928, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=275, Percent_Identity=24.7272727272727, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=28.6792452830189, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648116, Length=270, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=29.5180722891566, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29034; Mature: 29034

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGIGPSYLEERLPGGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLSEQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCCCCHHHH
LKALYEYNFSQAIQKAVEATNKKARGK
HHHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGIGPSYLEERLPGGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLSEQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCCCCHHHH
LKALYEYNFSQAIQKAVEATNKKARGK
HHHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 11418582 [H]