BacMap

Definition	Bacillus thuringiensis str. Al Hakam chromosome, complete genome.
Accession	NC_008600
Length	5,257,091

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The map label for this gene is yvgN [H]

Identifier: 118475961

GI number: 118475961

Start: 205803

End: 206636

Strand: Reverse

Name: yvgN [H]

Synonym: BALH_0196

Alternate gene names: 118475961

Gene position: 206636-205803 (Counterclockwise)

Preceding gene: 118475962

Following gene: 118475960

Centisome position: 3.93

GC content: 35.25

Gene sequence:

>834_bases
ATGAATTTAACAAGTTTAAAAGACTATACAACATTACATAACGGTGTAAAAATGCCTTGGTTCGGTTTAGGTGTTTTTAA
AGTAGAAGATGGTTCACAAGTAATTGATTCTGTAAAAGCAGCAATTAAAAATGGCTACCGCAGTATCGATACTGCAGCAA
TCTATCAAAACGAAGAAGGCGTTGGACAAGCGATCCGTGAATCAGGTGTTTCACGTGAAGAATTATTTATCACATCAAAA
GTATGGAATAGCGATCAAGGATATGAAACAACACTTCAAGCATTTGAAACTACATTAGAAAAATTAGGTCTAGAATATTT
AGATTTATATTTAGTACATTGGCCTGTAAAAGGGAAATATACTGAATCGTGGAAAGCGTTAGAAAAGCTTTATAAAGATG
GCCGTGTTCGTGCTATCGGTGTGAGCAATTTCCACGTTCACCACTTACAAGACATATTTGAAATTGCTGAAATTAAACCA
ATGGTCAACCAAGTGGAATACCACCCACGTTTAGCACAAGAAGAGTTACACGCTTTCTGTAAAGAACATAACATCCAGCT
TGAAGCTTGGTCACCATTAATGCAAGGACAACTACTGGATAACCCAACATTACAAGACATTGCGAAAAAATATAATAAAT
CAACTGCGCAAATTATTTTACGCTGGGATTTACAAAACGAAGTTGTAACAATTCCTAAATCCATTAAAGAACATCGCATT
ATTGAAAATGCAAACATCTTCGACTTTGAATTAAGTGCTGACGATATGAAAGCAATTCAAGCTTTAAATGAAGATCGCCG
CGTTGGTCCAGATCCAGATAACTTTAATTTCTAA

Upstream 100 bases:

>100_bases
TCCACAGCTGAAGGTCTCAAAGCTTTATATGAATATAATTTTTCACAGGCAATTCAAAAAGCAGTAGAAGCAACAAACAA
AAAAGCTAGGGGGAAATAAT

Downstream 100 bases:

>100_bases
GCGAAAAACCACTGTACATAATGCAGTGGTTTTTCTTAATTAAAAACTGAAAATTTAAACTATATTCAATTTAATTGACA
GTTTATTGTGCAAGGTGTAA

Product: aldo/keto reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNLTSLKDYTTLHNGVKMPWFGLGVFKVEDGSQVIDSVKAAIKNGYRSIDTAAIYQNEEGVGQAIRESGVSREELFITSK
VWNSDQGYETTLQAFETTLEKLGLEYLDLYLVHWPVKGKYTESWKALEKLYKDGRVRAIGVSNFHVHHLQDIFEIAEIKP
MVNQVEYHPRLAQEELHAFCKEHNIQLEAWSPLMQGQLLDNPTLQDIAKKYNKSTAQIILRWDLQNEVVTIPKSIKEHRI
IENANIFDFELSADDMKAIQALNEDRRVGPDPDNFNF

Sequences:

>Translated_277_residues
MNLTSLKDYTTLHNGVKMPWFGLGVFKVEDGSQVIDSVKAAIKNGYRSIDTAAIYQNEEGVGQAIRESGVSREELFITSK
VWNSDQGYETTLQAFETTLEKLGLEYLDLYLVHWPVKGKYTESWKALEKLYKDGRVRAIGVSNFHVHHLQDIFEIAEIKP
MVNQVEYHPRLAQEELHAFCKEHNIQLEAWSPLMQGQLLDNPTLQDIAKKYNKSTAQIILRWDLQNEVVTIPKSIKEHRI
IENANIFDFELSADDMKAIQALNEDRRVGPDPDNFNF
>Mature_277_residues
MNLTSLKDYTTLHNGVKMPWFGLGVFKVEDGSQVIDSVKAAIKNGYRSIDTAAIYQNEEGVGQAIRESGVSREELFITSK
VWNSDQGYETTLQAFETTLEKLGLEYLDLYLVHWPVKGKYTESWKALEKLYKDGRVRAIGVSNFHVHHLQDIFEIAEIKP
MVNQVEYHPRLAQEELHAFCKEHNIQLEAWSPLMQGQLLDNPTLQDIAKKYNKSTAQIILRWDLQNEVVTIPKSIKEHRI
IENANIFDFELSADDMKAIQALNEDRRVGPDPDNFNF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=43.6426116838488, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=43.6426116838488, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI223468663, Length=298, Percent_Identity=38.5906040268456, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI5174695, Length=307, Percent_Identity=37.1335504885993, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=41.6382252559727, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=38.6206896551724, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI5453543, Length=310, Percent_Identity=36.4516129032258, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI291291012, Length=272, Percent_Identity=37.8676470588235, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI310109920, Length=310, Percent_Identity=36.4516129032258, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=36.4516129032258, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=36.4516129032258, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=35.5263157894737, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI24497583, Length=293, Percent_Identity=36.8600682593857, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI24497585, Length=295, Percent_Identity=36.6101694915254, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI300116273, Length=283, Percent_Identity=36.0424028268551, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI300116271, Length=285, Percent_Identity=36.140350877193, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI310109924, Length=169, Percent_Identity=37.2781065088757, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=41.2280701754386, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=41.2280701754386, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=46.0966542750929, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI1786400, Length=261, Percent_Identity=37.9310344827586, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788081, Length=260, Percent_Identity=32.6923076923077, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788070, Length=217, Percent_Identity=26.2672811059908, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87081735, Length=207, Percent_Identity=25.6038647342995, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=43.4456928838951, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=37, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17537075, Length=297, Percent_Identity=39.0572390572391, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=38.013698630137, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=34.8148148148148, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17537079, Length=305, Percent_Identity=33.7704918032787, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17538386, Length=271, Percent_Identity=35.4243542435424, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=36.6666666666667, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=34.0579710144928, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=31.1355311355311, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=34.0277777777778, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=31.5018315018315, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17550246, Length=81, Percent_Identity=50.6172839506173, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=285, Percent_Identity=38.5964912280702, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=37.1527777777778, Blast_Score=195, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=35.0157728706625, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=35.3846153846154, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319625, Length=299, Percent_Identity=36.4548494983278, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=34.6289752650177, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24663317, Length=292, Percent_Identity=40.4109589041096, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=37.542662116041, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129731, Length=296, Percent_Identity=37.8378378378378, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24657054, Length=301, Percent_Identity=37.5415282392027, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=32.7814569536424, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI21356425, Length=301, Percent_Identity=34.5514950166113, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=38.8316151202749, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24662781, Length=293, Percent_Identity=38.5665529010239, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=33.5640138408304, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=30.7453416149068, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=33.59375, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31840; Mature: 31840

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTSLKDYTTLHNGVKMPWFGLGVFKVEDGSQVIDSVKAAIKNGYRSIDTAAIYQNEEG
CCCCCCHHHHHHHCCCCCCEEECEEEEECCCHHHHHHHHHHHHCCCCCCCHHHEECCCCH
VGQAIRESGVSREELFITSKVWNSDQGYETTLQAFETTLEKLGLEYLDLYLVHWPVKGKY
HHHHHHHCCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHEEECCCCCC
TESWKALEKLYKDGRVRAIGVSNFHVHHLQDIFEIAEIKPMVNQVEYHPRLAQEELHAFC
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KEHNIQLEAWSPLMQGQLLDNPTLQDIAKKYNKSTAQIILRWDLQNEVVTIPKSIKEHRI
HHCCCEEEECCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEECCHHHHHHHH
IENANIFDFELSADDMKAIQALNEDRRVGPDPDNFNF
HCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLTSLKDYTTLHNGVKMPWFGLGVFKVEDGSQVIDSVKAAIKNGYRSIDTAAIYQNEEG
CCCCCCHHHHHHHCCCCCCEEECEEEEECCCHHHHHHHHHHHHCCCCCCCHHHEECCCCH
VGQAIRESGVSREELFITSKVWNSDQGYETTLQAFETTLEKLGLEYLDLYLVHWPVKGKY
HHHHHHHCCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHEEECCCCCC
TESWKALEKLYKDGRVRAIGVSNFHVHHLQDIFEIAEIKPMVNQVEYHPRLAQEELHAFC
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KEHNIQLEAWSPLMQGQLLDNPTLQDIAKKYNKSTAQIILRWDLQNEVVTIPKSIKEHRI
HHCCCEEEECCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEECCHHHHHHHH
IENANIFDFELSADDMKAIQALNEDRRVGPDPDNFNF
HCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]