Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 118475802

GI number: 118475802

Start: 35986

End: 36612

Strand: Direct

Name: tmk [H]

Synonym: BALH_0026

Alternate gene names: 118475802

Gene position: 35986-36612 (Clockwise)

Preceding gene: 118475801

Following gene: 118475803

Centisome position: 0.68

GC content: 36.04

Gene sequence:

>627_bases
ATGAAGGGATTATTTGTAACAATTGAAGGTCCAGAAGGTTCGGGTAAAACAACATTAATTCAAAGTTTATTGCCATACTT
TGAACAAAAGGAACAAAAGGTAATGGCGACGAGAGAACCGGGTGGTATTGCAATTTCTGAGGATATTAGAACGATTTTGC
ATAAACAAGAATATACGATGATGGAAGCACGTACAGAGGCACTATTATATGCTGCTGCACGTAGACAGCATTTAGTAGAA
AAAGTTATGCCGGCGCTTAATGATGATTACCTTGTATTATGTGATCGTTTTATAGATAGCTCTTTAGCGTATCAAGGATA
TGCAAGAGGATTAGGTATGGATAAAGTATTTGAAATAAATCGTTTCGCAACAGAGGACTGTATGCCTAGTTTAACAATTT
ACTTAGATATTGAGCCAGAGGTTGGCTTAGCGCGAATTGCAAAAGATGCAGGACGTGAAGTGAATCGGTTAGATATGGAA
GATATCTCTTTCCATAAACGTGTGCGTGAAGGGTATTTACAAGTTGTAGAACGTTTTTCGGATCGTATTGTATTAGTAAA
TGCTGATCAACCAATGGAAAAACTTATAGAAGAAGTTATTCAGGTTATAGAAGATAAATTGTTATAA

Upstream 100 bases:

>100_bases
GAACATAAAGAACAAATTATGTATTTAGAAAAAGCAGGTGCTCGTTTTCAAGGTAGCACGAAATATATGAAAGTGTATGA
TATAGAAAGTAGGTTTTAGG

Downstream 100 bases:

>100_bases
TAGAAGGAAAGACTGAAATAAGTGAGGTATGCATTATGACGAAGACGTGGGAGCAGCTTTCTGCTATACAACCCATCGGT
GTAAAAATGTTGATGAATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNDDYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVIQVIEDKLL

Sequences:

>Translated_208_residues
MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNDDYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVIQVIEDKLL
>Mature_208_residues
MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNDDYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVIQVIEDKLL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=35.2941176470588, Blast_Score=104, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23791; Mature: 23791

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALNDDYLVLCDRFIDSSLAYQGYARGLGMDKVFEIN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDMEDISFHKRVREGYLQVVERFS
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
DRIVLVNADQPMEKLIEEVIQVIEDKLL
CCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALNDDYLVLCDRFIDSSLAYQGYARGLGMDKVFEIN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDMEDISFHKRVREGYLQVVERFS
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
DRIVLVNADQPMEKLIEEVIQVIEDKLL
CCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA