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The map label for this gene is cad [H]

Identifier: 118475801

GI number: 118475801

Start: 34563

End: 35984

Strand: Direct

Name: cad [H]

Synonym: BALH_0025

Alternate gene names: 118475801

Gene position: 34563-35984 (Clockwise)

Preceding gene: 118475800

Following gene: 118475802

Centisome position: 0.66

GC content: 35.16

Gene sequence:

>1422_bases
ATGAATCAAAATCGCATACCTTTATATGAAGCATTAATAGAGTTTAAAGAAAGAAGGCCGTTATCCTTTCATGTTCCAGG
TCATAAAAATGGTTTAAACTTCCCTCAGGAGGTAGTAGAGGAGTTTAAAGATATACTATCTATCGATGTAACTGAGTTAT
CAGGATTAGATGATTTACATAGTCCGTTTGAATGTATAGATGAGGCACAACAATTATTAGCTGATGTATATGGAGTGAAC
AAAAGTTATTTTTTAATTAATGGTTCAACAGTGGGGAACCTAGCAATGATTTTGTCTTGTTGTGGGGAACATGATATTGT
TCTTGTACAAAGAAATTGTCATAAATCGATTATTAATGGTTTAAAATTAGCGGGAGCAAATCCTATTTTTTTAGATCCAT
GGATTGATGAAGTTTATAACGTACCAGTGGGAATTCATGATGAGATTATCAAGGAAGCAATTGAAAAATACCCAAATGCG
AAAGCACTCATTTTAACGCATCCTAATTATTATGGTATGGGGATGGATCTAGAGGCAAGCATTGCTTATGCACATGCGCA
TAAAATCCCTGTGCTAGTAGATGAAGCACATGGGGCTCATTTTTGTTTAGGCGGGGCATTTCCAAAGTCAGCGTTAGCAT
ATGGTGCAGATATTGTAGTTCATTCTGCGCATAAAACATTACCCGCGATGACGATGGGATCCTATTTACATATAAATAGT
CGCTTAGTGAAAGAAGAAAAAGTTTCTACTTATTTAAGTATGCTACAATCTAGTAGTCCATCGTATCCAATTATGGCTTC
TCTTGATATTGCACGCTTTACAATAGCACGTATAAAAGAAAAGGGACATGATGAAATTGTCGAGTTTTTACAGGAATTTA
AAGAAGAATTGAGTACTATTCCACAAATAGCTATTTTACAATATCCATTACAAGACGGGCTAAAGATTACCGTACAGACG
CGTTGTCAGTTATCGGGATACGAATTACAGTCTGTATTTGAAAAGGTCGGTATATATACAGAAATGGCAGATCCATATAA
TGTCTTATTTATTTTGCCTTTGCAAGTAAATAAGAAATATATGAAGGCTATAGAGATGATCCGAGTGGCATTGCAATACT
ATGAGGTGAAAGACAAGACGGAATCTATTCGTTATACTTATAAAGGAGAAATTTCTCCCCTGCCGTATACATATAAACAA
CTGGAAGAATACGAAACAAAAGTAGTACCTGTAGAAGAAGCAGTTGGGATGGTAGCAGCGGAAATGGTAATTCCGTATCC
ACCTGGTATTCCATTGATTATGTATGGAGAAAGAATTACTTCAGAACATAAAGAACAAATTATGTATTTAGAAAAAGCAG
GTGCTCGTTTTCAAGGTAGCACGAAATATATGAAAGTGTATGATATAGAAAGTAGGTTTTAG

Upstream 100 bases:

>100_bases
TCGAAAATTAGAAGTATCATATTTTTAAATAGGCATATGCCTATTATTTTTTTTGTTCTGTATAATAGATAAAGAATGAA
ATAATAAGGAAGAGATATAG

Downstream 100 bases:

>100_bases
GATGAAGGGATTATTTGTAACAATTGAAGGTCCAGAAGGTTCGGGTAAAACAACATTAATTCAAAGTTTATTGCCATACT
TTGAACAAAAGGAACAAAAG

Product: lysine decarboxylase

Products: cadaverine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNQNRIPLYEALIEFKERRPLSFHVPGHKNGLNFPQEVVEEFKDILSIDVTELSGLDDLHSPFECIDEAQQLLADVYGVN
KSYFLINGSTVGNLAMILSCCGEHDIVLVQRNCHKSIINGLKLAGANPIFLDPWIDEVYNVPVGIHDEIIKEAIEKYPNA
KALILTHPNYYGMGMDLEASIAYAHAHKIPVLVDEAHGAHFCLGGAFPKSALAYGADIVVHSAHKTLPAMTMGSYLHINS
RLVKEEKVSTYLSMLQSSSPSYPIMASLDIARFTIARIKEKGHDEIVEFLQEFKEELSTIPQIAILQYPLQDGLKITVQT
RCQLSGYELQSVFEKVGIYTEMADPYNVLFILPLQVNKKYMKAIEMIRVALQYYEVKDKTESIRYTYKGEISPLPYTYKQ
LEEYETKVVPVEEAVGMVAAEMVIPYPPGIPLIMYGERITSEHKEQIMYLEKAGARFQGSTKYMKVYDIESRF

Sequences:

>Translated_473_residues
MNQNRIPLYEALIEFKERRPLSFHVPGHKNGLNFPQEVVEEFKDILSIDVTELSGLDDLHSPFECIDEAQQLLADVYGVN
KSYFLINGSTVGNLAMILSCCGEHDIVLVQRNCHKSIINGLKLAGANPIFLDPWIDEVYNVPVGIHDEIIKEAIEKYPNA
KALILTHPNYYGMGMDLEASIAYAHAHKIPVLVDEAHGAHFCLGGAFPKSALAYGADIVVHSAHKTLPAMTMGSYLHINS
RLVKEEKVSTYLSMLQSSSPSYPIMASLDIARFTIARIKEKGHDEIVEFLQEFKEELSTIPQIAILQYPLQDGLKITVQT
RCQLSGYELQSVFEKVGIYTEMADPYNVLFILPLQVNKKYMKAIEMIRVALQYYEVKDKTESIRYTYKGEISPLPYTYKQ
LEEYETKVVPVEEAVGMVAAEMVIPYPPGIPLIMYGERITSEHKEQIMYLEKAGARFQGSTKYMKVYDIESRF
>Mature_473_residues
MNQNRIPLYEALIEFKERRPLSFHVPGHKNGLNFPQEVVEEFKDILSIDVTELSGLDDLHSPFECIDEAQQLLADVYGVN
KSYFLINGSTVGNLAMILSCCGEHDIVLVQRNCHKSIINGLKLAGANPIFLDPWIDEVYNVPVGIHDEIIKEAIEKYPNA
KALILTHPNYYGMGMDLEASIAYAHAHKIPVLVDEAHGAHFCLGGAFPKSALAYGADIVVHSAHKTLPAMTMGSYLHINS
RLVKEEKVSTYLSMLQSSSPSYPIMASLDIARFTIARIKEKGHDEIVEFLQEFKEELSTIPQIAILQYPLQDGLKITVQT
RCQLSGYELQSVFEKVGIYTEMADPYNVLFILPLQVNKKYMKAIEMIRVALQYYEVKDKTESIRYTYKGEISPLPYTYKQ
LEEYETKVVPVEEAVGMVAAEMVIPYPPGIPLIMYGERITSEHKEQIMYLEKAGARFQGSTKYMKVYDIESRF

Specific function: Ldc Is Constitutively But Weakly Expressed Under Various Conditions. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=554, Percent_Identity=22.2021660649819, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790573, Length=565, Percent_Identity=23.1858407079646, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI221142684, Length=415, Percent_Identity=24.0963855421687, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786909, Length=144, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C [H]

EC number: 4.1.1.18

Molecular weight: Translated: 53520; Mature: 53520

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNRIPLYEALIEFKERRPLSFHVPGHKNGLNFPQEVVEEFKDILSIDVTELSGLDDLH
CCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHEECHHHHCCCHHHC
SPFECIDEAQQLLADVYGVNKSYFLINGSTVGNLAMILSCCGEHDIVLVQRNCHKSIING
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCHHHHHHCC
LKLAGANPIFLDPWIDEVYNVPVGIHDEIIKEAIEKYPNAKALILTHPNYYGMGMDLEAS
CEECCCCCEEECHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHH
IAYAHAHKIPVLVDEAHGAHFCLGGAFPKSALAYGADIVVHSAHKTLPAMTMGSYLHINS
EEEHHHCCCCEEEECCCCCEEEECCCCCHHHHHCCCCEEEECCHHCCCHHHCCCEEEECH
RLVKEEKVSTYLSMLQSSSPSYPIMASLDIARFTIARIKEKGHDEIVEFLQEFKEELSTI
HHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
PQIAILQYPLQDGLKITVQTRCQLSGYELQSVFEKVGIYTEMADPYNVLFILPLQVNKKY
CCEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHCCEEECCCCCEEEEEEEECCCHHH
MKAIEMIRVALQYYEVKDKTESIRYTYKGEISPLPYTYKQLEEYETKVVPVEEAVGMVAA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHH
EMVIPYPPGIPLIMYGERITSEHKEQIMYLEKAGARFQGSTKYMKVYDIESRF
HEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MNQNRIPLYEALIEFKERRPLSFHVPGHKNGLNFPQEVVEEFKDILSIDVTELSGLDDLH
CCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHEECHHHHCCCHHHC
SPFECIDEAQQLLADVYGVNKSYFLINGSTVGNLAMILSCCGEHDIVLVQRNCHKSIING
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCHHHHHHCC
LKLAGANPIFLDPWIDEVYNVPVGIHDEIIKEAIEKYPNAKALILTHPNYYGMGMDLEAS
CEECCCCCEEECHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHH
IAYAHAHKIPVLVDEAHGAHFCLGGAFPKSALAYGADIVVHSAHKTLPAMTMGSYLHINS
EEEHHHCCCCEEEECCCCCEEEECCCCCHHHHHCCCCEEEECCHHCCCHHHCCCEEEECH
RLVKEEKVSTYLSMLQSSSPSYPIMASLDIARFTIARIKEKGHDEIVEFLQEFKEELSTI
HHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
PQIAILQYPLQDGLKITVQTRCQLSGYELQSVFEKVGIYTEMADPYNVLFILPLQVNKKY
CCEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHCCEEECCCCCEEEEEEEECCCHHH
MKAIEMIRVALQYYEVKDKTESIRYTYKGEISPLPYTYKQLEEYETKVVPVEEAVGMVAA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHH
EMVIPYPPGIPLIMYGERITSEHKEQIMYLEKAGARFQGSTKYMKVYDIESRF
HEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate; Sulfhydryl groups [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.4 {S-aminoethyl-L-Cys}} 2 {L-Lys}} 1.5 {L-Lys}} 7 {delta-hydroxylysine}} [C]

Substrates: L-lysine

Specific reaction: L-lysine = cadaverine + CO2

General reaction: Decarboxylation [C]

Inhibitor: NaBH4; NaCl [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]