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The map label for this gene is metR [H]

Identifier: 117921907

GI number: 117921907

Start: 4161834

End: 4162739

Strand: Direct

Name: metR [H]

Synonym: Shewana3_3470

Alternate gene names: 117921907

Gene position: 4161834-4162739 (Clockwise)

Preceding gene: 117921905

Following gene: 117921913

Centisome position: 83.7

GC content: 50.77

Gene sequence:

>906_bases
ATGATCGAACTAAGACATCTGCGAACCTTAATGGCACTGAAGGAAAGTGGCAGCTTGGCGGGCGCAGCCAAAAAACGTTT
TGTCACTCAATCGGCTCTCTCCCATCAAATTAAGGAGTTAGAGCAACGAATTAACTCGCCCATTTTTGTGCGTAAAAGCA
AACCCCTCTCCTTTACTCAAGAAGGCGCACGCCTGTTGCACCTCGCCGAAGAGATCCTGCCGAAGGTGTTAGAAACGGAA
ACGGATCTGAAAAATGGCCTAGAGACAGAGACCAATCAGCTCAGAGTGGGGATTGAATGCCACAGCTGTTTTCGCTGGTT
AATGCCAGTGATGGAGCAATTTAGGCAAGATCATCCGCAGGCCGAGTTAGATCTGTCGAGCCGTCACCTGTTCGATTCGC
TCAATGCCTTAGAAATGGGCGAACTCGATATAGTGCTGACCTCAGATCCCGTGCCGGGGCACTCGCTCGCCTATCAGCAT
TTGTTTGATTTTGAAGTGAAGTTAGTGGTTGCCAAGGATCATCCCTTAGCGAAAGAAGCCTATGTTACGCCTAAGCAATT
GACGCGTTTACCCATAATCAGCTACCCAGTGCCACTGGCGCGTTTAGATATTTACCGCCACTTTTTAGAACCCGCAGGTG
TTGAGGCTGGCGAACAAAAGACCTGCGATTTGACCATGATGTTATTGCAACGCATCGCCTGTAAGGACGGCATCGCCGCC
CTGCCCAACTGGTCAATCAATGAGGGACATGGATTGAGCCTCGCCGCCGTTAAACTGGGTCAAGAAGGCTTAAAACGCCC
GCTATTTGGTGCCTACCGCCGCCACAGCGCGAACTCGGCCTTAGTGCAAAACTGGTTGCAACTGGTGGCCAGCGAAGGCT
TAGCGCGTCAGCAAAAATCCAATTAG

Upstream 100 bases:

>100_bases
AATGGGCGTCTGGACGTCTAGAAGTTTATTGTGATAGTCTCTATGCCAGCAACCGAATTGATTTCAAGCACAACATGAGC
GAAATTCACTTGGAGTGATC

Downstream 100 bases:

>100_bases
CGCCGTAAAAACAGCATAAAAAAGCCTGCAATCGCAGGCTTTTTTATTAAAGGCACATTCCTAGAGCGGGTTGAGCAACA
TGCCACGCATCGAGAGCACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDHPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLTRLPIISYPVPLARLDIYRHFLEPAGVEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLARQQKSN

Sequences:

>Translated_301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDHPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLTRLPIISYPVPLARLDIYRHFLEPAGVEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLARQQKSN
>Mature_301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDHPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLTRLPIISYPVPLARLDIYRHFLEPAGVEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLARQQKSN

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=273, Percent_Identity=46.8864468864469, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1788887, Length=193, Percent_Identity=30.5699481865285, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082024, Length=175, Percent_Identity=33.1428571428571, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787601, Length=293, Percent_Identity=22.8668941979522, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=27.6923076923077, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=32.1608040201005, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790208, Length=195, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI157672245, Length=287, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=24.6073298429319, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786401, Length=169, Percent_Identity=26.0355029585799, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788296, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082132, Length=176, Percent_Identity=28.9772727272727, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33837; Mature: 33837

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHH
EGARLLHLAEEILPKVLETETDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDHPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC
AELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQHLFDFEVKLVVAKDHPLAKEA
CCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCHHH
YVTPKQLTRLPIISYPVPLARLDIYRHFLEPAGVEAGEQKTCDLTMMLLQRIACKDGIAA
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLARQQKS
CCCCCCCCCCCCCHHHHHHCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
N
C
>Mature Secondary Structure
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHH
EGARLLHLAEEILPKVLETETDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDHPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC
AELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQHLFDFEVKLVVAKDHPLAKEA
CCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCHHH
YVTPKQLTRLPIISYPVPLARLDIYRHFLEPAGVEAGEQKTCDLTMMLLQRIACKDGIAA
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLARQQKS
CCCCCCCCCCCCCHHHHHHCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]