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The map label for this gene is folK [H]

Identifier: 117921844

GI number: 117921844

Start: 4076228

End: 4076716

Strand: Direct

Name: folK [H]

Synonym: Shewana3_3407

Alternate gene names: 117921844

Gene position: 4076228-4076716 (Clockwise)

Preceding gene: 117921843

Following gene: 117921845

Centisome position: 81.98

GC content: 51.33

Gene sequence:

>489_bases
ATGACTCAGGTTTTTGTCGCCCTCGGGGCTAATCTTGAAGATCCTAAAGCTCAGCTGGACAATGCCGTTGCGGCCTTGTC
CGCCTTGGCTGAACATCAGAGTCTTAAGGTATCGCCCTATTACGGTTCCACCCCCATGGGGGACGTAGTGCAACCCGACT
ATATCAATGCCGTTGCCAGCTTTGAGACCTCTCTGGCACCCATCGCCCTGTTAGATGCACTGCAAGAGATTGAAAACACT
CAGGGCCGTGTTCGTAAAGAACGTTGGGGCCCCAGAACCTTAGATCTCGACTTACTCTTATATGGCGATGCCATTATCGA
TGAGCCCAGACTCAAAGTGCCACACTACGGCATGAAGGAGCGTAGTTTTGTGCTAGTGCCCTTGGCGGCCATAGCACCGG
ATCTGGTGTTACCTTGTAAAACGCCGCTACGCAGCCTTATCAGTGAAAAATTCTTGGCCGAGTTACAACTACTGGGCAAT
GATCATTGA

Upstream 100 bases:

>100_bases
TCGCCCGCAGTGGTAACAAAGCGGCGGGTAACCGTAACCGCAATTCACCACAGCGCCGTCGCCGTCGCCCGAGTGCCGCT
AAAGCCAAAGCCGCCGAATA

Downstream 100 bases:

>100_bases
AGTCAGCCCCCAGTTAGCTTATAACACCACTTCTATTTGGTTTGAAGATCACCCATATGTCTAAAGTTACTAGCTCAACC
CTGTTGAAATACAAACAGGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTQVFVALGANLEDPKAQLDNAVAALSALAEHQSLKVSPYYGSTPMGDVVQPDYINAVASFETSLAPIALLDALQEIENT
QGRVRKERWGPRTLDLDLLLYGDAIIDEPRLKVPHYGMKERSFVLVPLAAIAPDLVLPCKTPLRSLISEKFLAELQLLGN
DH

Sequences:

>Translated_162_residues
MTQVFVALGANLEDPKAQLDNAVAALSALAEHQSLKVSPYYGSTPMGDVVQPDYINAVASFETSLAPIALLDALQEIENT
QGRVRKERWGPRTLDLDLLLYGDAIIDEPRLKVPHYGMKERSFVLVPLAAIAPDLVLPCKTPLRSLISEKFLAELQLLGN
DH
>Mature_161_residues
TQVFVALGANLEDPKAQLDNAVAALSALAEHQSLKVSPYYGSTPMGDVVQPDYINAVASFETSLAPIALLDALQEIENTQ
GRVRKERWGPRTLDLDLLLYGDAIIDEPRLKVPHYGMKERSFVLVPLAAIAPDLVLPCKTPLRSLISEKFLAELQLLGND
H

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=157, Percent_Identity=49.0445859872611, Blast_Score=151, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=34.0740740740741, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17748; Mature: 17616

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVFVALGANLEDPKAQLDNAVAALSALAEHQSLKVSPYYGSTPMGDVVQPDYINAVAS
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHH
FETSLAPIALLDALQEIENTQGRVRKERWGPRTLDLDLLLYGDAIIDEPRLKVPHYGMKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCC
RSFVLVPLAAIAPDLVLPCKTPLRSLISEKFLAELQLLGNDH
CCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQVFVALGANLEDPKAQLDNAVAALSALAEHQSLKVSPYYGSTPMGDVVQPDYINAVAS
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHH
FETSLAPIALLDALQEIENTQGRVRKERWGPRTLDLDLLLYGDAIIDEPRLKVPHYGMKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCC
RSFVLVPLAAIAPDLVLPCKTPLRSLISEKFLAELQLLGNDH
CCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]