Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 117921626

GI number: 117921626

Start: 3825989

End: 3826867

Strand: Reverse

Name: cysM [H]

Synonym: Shewana3_3188

Alternate gene names: 117921626

Gene position: 3826867-3825989 (Counterclockwise)

Preceding gene: 117921631

Following gene: 117921624

Centisome position: 76.97

GC content: 52.56

Gene sequence:

>879_bases
GTGTCTGACTTTCCGACTATTGAAGCCTGTATTGGGCAAACTCCGCTGGTACGTTTGCAGCGGCTTGATTGTGGTAGCTC
AACGGTATTGTTAAAGCTGGAGGGGAATAACCCTGCTGGCTCGGTAAAGGATCGCGCGGCGCTGAATATGATTATTCAGG
CGGAGCTTCGCCAAGAGATAGCCCCCGGGGATACCCTGATTGAAGCCACCAGTGGCAATACGGGCATCGCCTTAGCCATG
GCTGCGGCGATTAAAGGCTACAAGATGATCCTGATCATGCCGTCAAATTCGACCCAAGAGCGTAAGGATGCCATGCAGGC
CTATGGCGCCGAGTTGCTGCTGGTGGACAATATGGAAGCCGCGCGGGATTTAGCCTTAGATCTTCAGGCACAAGGCAAAG
GTAAGGTGCTGGATCAGTTCAATAATCAAGATAATGCCAACGCCCATTTTCAGACTACTGGCCCCGAAATTTGGCAGCAG
AGCCAAGGTAAGATCACTCACTTTGTCTCTAGCATGGGTACCACAGGCACTATTATGGGCGTGTCTAAATACTTAAAGAG
TCGTAATCCCGATATCACTATTGTCGGGCTACAACCCGCCGATGGCAGTTCGATTCCGGGGATTCGCCGCTGGCCGCAGG
AATATCTACCGGGTATTTTCGATGCTGCCCGTGTCGATGCCGTGATGGACATTGAGGAGCAAGACGCCAAAGCTATGGCG
AGAACCTTGGCCCGTGAAGAAGGTATTTGTGCTGGCGTGAGTTCTGGCGGCGCGGTATTTGCGGCGCTCGAGATTGCGAG
GCAGAATCCGGGGTCCGTTGTAGTCGCAATTGTGTGTGATAGGGGCGACCGTTATCTGTCATCAGGGTTATTTTCTTAA

Upstream 100 bases:

>100_bases
ATTAATTGTATGCCGTTGATGATATTCACGTGTTTGTTGCGTCCAAGCATCTTAAAATACCCAAATACTGAGTCGCTTTT
ATCAAATAAAGGATAACCGA

Downstream 100 bases:

>100_bases
CCCTAACTAAGCTTACGCTTAGGGTTTGACCTTCCTTTGGCAATAAAAATGGGCGTTAATCGCCCATTTTTATTGGCTAT
TGCATAAGCCACGGTGATTT

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSDFPTIEACIGQTPLVRLQRLDCGSSTVLLKLEGNNPAGSVKDRAALNMIIQAELRQEIAPGDTLIEATSGNTGIALAM
AAAIKGYKMILIMPSNSTQERKDAMQAYGAELLLVDNMEAARDLALDLQAQGKGKVLDQFNNQDNANAHFQTTGPEIWQQ
SQGKITHFVSSMGTTGTIMGVSKYLKSRNPDITIVGLQPADGSSIPGIRRWPQEYLPGIFDAARVDAVMDIEEQDAKAMA
RTLAREEGICAGVSSGGAVFAALEIARQNPGSVVVAIVCDRGDRYLSSGLFS

Sequences:

>Translated_292_residues
MSDFPTIEACIGQTPLVRLQRLDCGSSTVLLKLEGNNPAGSVKDRAALNMIIQAELRQEIAPGDTLIEATSGNTGIALAM
AAAIKGYKMILIMPSNSTQERKDAMQAYGAELLLVDNMEAARDLALDLQAQGKGKVLDQFNNQDNANAHFQTTGPEIWQQ
SQGKITHFVSSMGTTGTIMGVSKYLKSRNPDITIVGLQPADGSSIPGIRRWPQEYLPGIFDAARVDAVMDIEEQDAKAMA
RTLAREEGICAGVSSGGAVFAALEIARQNPGSVVVAIVCDRGDRYLSSGLFS
>Mature_291_residues
SDFPTIEACIGQTPLVRLQRLDCGSSTVLLKLEGNNPAGSVKDRAALNMIIQAELRQEIAPGDTLIEATSGNTGIALAMA
AAIKGYKMILIMPSNSTQERKDAMQAYGAELLLVDNMEAARDLALDLQAQGKGKVLDQFNNQDNANAHFQTTGPEIWQQS
QGKITHFVSSMGTTGTIMGVSKYLKSRNPDITIVGLQPADGSSIPGIRRWPQEYLPGIFDAARVDAVMDIEEQDAKAMAR
TLAREEGICAGVSSGGAVFAALEIARQNPGSVVVAIVCDRGDRYLSSGLFS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=35.6687898089172, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=35.6687898089172, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=35.6687898089172, Blast_Score=171, Evalue=6e-43,
Organism=Escherichia coli, GI2367138, Length=291, Percent_Identity=67.6975945017182, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=40.327868852459, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=41.2751677852349, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17562970, Length=297, Percent_Identity=40.0673400673401, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=40.5498281786942, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=40.133779264214, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17561720, Length=297, Percent_Identity=39.3939393939394, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=36.150234741784, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534315, Length=285, Percent_Identity=36.8421052631579, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147552, Length=284, Percent_Identity=36.6197183098592, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=32.7731092436975, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=310, Percent_Identity=34.8387096774194, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=33.641975308642, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=38.1410256410256, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=38.1410256410256, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31160; Mature: 31029

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFPTIEACIGQTPLVRLQRLDCGSSTVLLKLEGNNPAGSVKDRAALNMIIQAELRQEI
CCCCCCHHHHHCCCHHHEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
APGDTLIEATSGNTGIALAMAAAIKGYKMILIMPSNSTQERKDAMQAYGAELLLVDNMEA
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHH
ARDLALDLQAQGKGKVLDQFNNQDNANAHFQTTGPEIWQQSQGKITHFVSSMGTTGTIMG
HHHHEEEEECCCCCCHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHCCCCCHHHH
VSKYLKSRNPDITIVGLQPADGSSIPGIRRWPQEYLPGIFDAARVDAVMDIEEQDAKAMA
HHHHHHCCCCCEEEEEECCCCCCCCCCHHCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
RTLAREEGICAGVSSGGAVFAALEIARQNPGSVVVAIVCDRGDRYLSSGLFS
HHHHHHCCCEEECCCCCCEEEEEEHHHCCCCCEEEEEEECCCCHHHHCCCCC
>Mature Secondary Structure 
SDFPTIEACIGQTPLVRLQRLDCGSSTVLLKLEGNNPAGSVKDRAALNMIIQAELRQEI
CCCCCHHHHHCCCHHHEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
APGDTLIEATSGNTGIALAMAAAIKGYKMILIMPSNSTQERKDAMQAYGAELLLVDNMEA
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHH
ARDLALDLQAQGKGKVLDQFNNQDNANAHFQTTGPEIWQQSQGKITHFVSSMGTTGTIMG
HHHHEEEEECCCCCCHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHCCCCCHHHH
VSKYLKSRNPDITIVGLQPADGSSIPGIRRWPQEYLPGIFDAARVDAVMDIEEQDAKAMA
HHHHHHCCCCCEEEEEECCCCCCCCCCHHCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
RTLAREEGICAGVSSGGAVFAALEIARQNPGSVVVAIVCDRGDRYLSSGLFS
HHHHHHCCCEEECCCCCCEEEEEEHHHCCCCCEEEEEEECCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]