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The map label for this gene is hmp [H]

Identifier: 117921612

GI number: 117921612

Start: 3815059

End: 3816252

Strand: Direct

Name: hmp [H]

Synonym: Shewana3_3174

Alternate gene names: 117921612

Gene position: 3815059-3816252 (Clockwise)

Preceding gene: 117921611

Following gene: 117921615

Centisome position: 76.73

GC content: 45.73

Gene sequence:

>1194_bases
ATGTTGGATAGCCGTACCATCCAAGTGATTAAAAGCACCATTCCCCTACTCGAATCTGCTGGTCCCGTACTCACTCAACA
TTTTTACGAACGGATGTTTAAACACAATCCTGAGTTAAAAGATGTATTTAACTTGGCACATCAGCATTCAGGCGGTCAGC
CCGTAGCGCTGTTTAACGCAGTTGCGGCCTATGCCAAAAACATTGATAACTTAGGTGCACTCGGCTCGGCTGTAGAGCGC
ATCGCCCACAAACACACAGGATTTTTAATCCAACCAGAACAATATGCGATTGTCGGTAGCCACCTATTGGCGACACTCAA
AGAGCTGGGTGGAAAAGCCGTCACAGAAGAAGTATTAACAGCATGGGCCGATGCCTATGGATTTTTAGCCAATATCTTTA
TCAATCGTGAAGCACAGATTTATCAAGAAAGTGCTCAGCAGGATGGCGGCTGGTCTGGAGTGCGTGAATTTATCATCAGT
GAGAAAAAAGCCGAGTCCTTAGAAATAGCCTCCTTTGTATTAACGCCCGTAGATGGCAAAGCGGTAAAAGACTTTATTCC
AGGACAATACTTAAGCATTAAGGCGCAACATCCTAAGCTTGCCTTCGATGAAATTCGCCAATATTCGCTCTCGGATGCTC
CAAATGGTCAAAGCTATCGGATCACGGTAAAGCGTGAGCTTAATGGCCAAGTATCAAATCTACTGCACGATGTACTGCAA
GTCGGTGACACACTTTCAGTGATGCCACCTGCGGGCGATTTCACTTTAGCGGTTCAAGCTGAAACACCTGTCGTATTGAT
TTCAGCGGGGGTTGGACAAACGCCGATGAAGAGCATGTTAAATCAACTCTTAAAGCTTAGACATCCAAGTACAGTGACTT
GGTTACATGCCTGCGAACACGGTGGAGTACACGGATTTAAATCGGCCATCAAAAACAAACTCGGCCAACATGCGAATCTT
GCCAGCCATGTATGGTACAGAGAGCCGACAAAGGCTGATATGTTAGGCCAAGATTATGATTTTGAAGGCACAATGAACTT
AACCTCCGTCGCCGATAAAATCGTGGCCAACGCACATTACTATTTCTGTGGCCCGATTGGCTTTATGGCTTCAATTAAAC
AGCAATTACTCGCCTTCGGTGTACCTAGCGAGCAAATGCACTATGAAGTTTTTGGCCCCCATGCCGAACTCTAA

Upstream 100 bases:

>100_bases
ATCACACCTAACAGTTTTAGGTGTGATTTTTATTGATCCAAATCAAATGTATCTTTAAACTTATATAACATTCATAAATA
AAGCATGTTAAGGATTCATT

Downstream 100 bases:

>100_bases
GGCTGCAACGTCGTTATCAATCATCGATAATAACTCAAGCACAAAGCCATCTTCCCGTAAGGCAAGGTGGCTTAATGCTT
GTTCCATAAACGCTGAACTA

Product: globin

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLDSRTIQVIKSTIPLLESAGPVLTQHFYERMFKHNPELKDVFNLAHQHSGGQPVALFNAVAAYAKNIDNLGALGSAVER
IAHKHTGFLIQPEQYAIVGSHLLATLKELGGKAVTEEVLTAWADAYGFLANIFINREAQIYQESAQQDGGWSGVREFIIS
EKKAESLEIASFVLTPVDGKAVKDFIPGQYLSIKAQHPKLAFDEIRQYSLSDAPNGQSYRITVKRELNGQVSNLLHDVLQ
VGDTLSVMPPAGDFTLAVQAETPVVLISAGVGQTPMKSMLNQLLKLRHPSTVTWLHACEHGGVHGFKSAIKNKLGQHANL
ASHVWYREPTKADMLGQDYDFEGTMNLTSVADKIVANAHYYFCGPIGFMASIKQQLLAFGVPSEQMHYEVFGPHAEL

Sequences:

>Translated_397_residues
MLDSRTIQVIKSTIPLLESAGPVLTQHFYERMFKHNPELKDVFNLAHQHSGGQPVALFNAVAAYAKNIDNLGALGSAVER
IAHKHTGFLIQPEQYAIVGSHLLATLKELGGKAVTEEVLTAWADAYGFLANIFINREAQIYQESAQQDGGWSGVREFIIS
EKKAESLEIASFVLTPVDGKAVKDFIPGQYLSIKAQHPKLAFDEIRQYSLSDAPNGQSYRITVKRELNGQVSNLLHDVLQ
VGDTLSVMPPAGDFTLAVQAETPVVLISAGVGQTPMKSMLNQLLKLRHPSTVTWLHACEHGGVHGFKSAIKNKLGQHANL
ASHVWYREPTKADMLGQDYDFEGTMNLTSVADKIVANAHYYFCGPIGFMASIKQQLLAFGVPSEQMHYEVFGPHAEL
>Mature_397_residues
MLDSRTIQVIKSTIPLLESAGPVLTQHFYERMFKHNPELKDVFNLAHQHSGGQPVALFNAVAAYAKNIDNLGALGSAVER
IAHKHTGFLIQPEQYAIVGSHLLATLKELGGKAVTEEVLTAWADAYGFLANIFINREAQIYQESAQQDGGWSGVREFIIS
EKKAESLEIASFVLTPVDGKAVKDFIPGQYLSIKAQHPKLAFDEIRQYSLSDAPNGQSYRITVKRELNGQVSNLLHDVLQ
VGDTLSVMPPAGDFTLAVQAETPVVLISAGVGQTPMKSMLNQLLKLRHPSTVTWLHACEHGGVHGFKSAIKNKLGQHANL
ASHVWYREPTKADMLGQDYDFEGTMNLTSVADKIVANAHYYFCGPIGFMASIKQQLLAFGVPSEQMHYEVFGPHAEL

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=399, Percent_Identity=53.3834586466165, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1788104, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787658, Length=215, Percent_Identity=28.3720930232558, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321673, Length=410, Percent_Identity=34.8780487804878, Blast_Score=226, Evalue=7e-60,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR001709
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 43616; Mature: 43616

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSRTIQVIKSTIPLLESAGPVLTQHFYERMFKHNPELKDVFNLAHQHSGGQPVALFNA
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
VAAYAKNIDNLGALGSAVERIAHKHTGFLIQPEQYAIVGSHLLATLKELGGKAVTEEVLT
HHHHHHCCHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
AWADAYGFLANIFINREAQIYQESAQQDGGWSGVREFIISEKKAESLEIASFVLTPVDGK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCH
AVKDFIPGQYLSIKAQHPKLAFDEIRQYSLSDAPNGQSYRITVKRELNGQVSNLLHDVLQ
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
VGDTLSVMPPAGDFTLAVQAETPVVLISAGVGQTPMKSMLNQLLKLRHPSTVTWLHACEH
CCCCEEECCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
GGVHGFKSAIKNKLGQHANLASHVWYREPTKADMLGQDYDFEGTMNLTSVADKIVANAHY
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCE
YFCGPIGFMASIKQQLLAFGVPSEQMHYEVFGPHAEL
EEECHHHHHHHHHHHHHHCCCCCHHCEEEEECCCCCC
>Mature Secondary Structure
MLDSRTIQVIKSTIPLLESAGPVLTQHFYERMFKHNPELKDVFNLAHQHSGGQPVALFNA
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
VAAYAKNIDNLGALGSAVERIAHKHTGFLIQPEQYAIVGSHLLATLKELGGKAVTEEVLT
HHHHHHCCHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
AWADAYGFLANIFINREAQIYQESAQQDGGWSGVREFIISEKKAESLEIASFVLTPVDGK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCH
AVKDFIPGQYLSIKAQHPKLAFDEIRQYSLSDAPNGQSYRITVKRELNGQVSNLLHDVLQ
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
VGDTLSVMPPAGDFTLAVQAETPVVLISAGVGQTPMKSMLNQLLKLRHPSTVTWLHACEH
CCCCEEECCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
GGVHGFKSAIKNKLGQHANLASHVWYREPTKADMLGQDYDFEGTMNLTSVADKIVANAHY
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCE
YFCGPIGFMASIKQQLLAFGVPSEQMHYEVFGPHAEL
EEECHHHHHHHHHHHHHHCCCCCHHCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]