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The map label for this gene is clcA [H]

Identifier: 117921507

GI number: 117921507

Start: 3680295

End: 3682019

Strand: Direct

Name: clcA [H]

Synonym: Shewana3_3069

Alternate gene names: 117921507

Gene position: 3680295-3682019 (Clockwise)

Preceding gene: 117921504

Following gene: 117921508

Centisome position: 74.02

GC content: 50.96

Gene sequence:

>1725_bases
GTGCAATTAACGATAAATAAAGCCGCGATTCAAGACGCCATCAGCACAGCTAAAAAGTACTTAACTAACGAGCTGCGCGA
TCATTTATCCCAAGCCAAGATCAGTGCGCAGTTGTGCTTACTGGCCTTGCTATTCGCCATCTTCGCCTCCTGCGTGATCC
TGTTGTTTCGACTCTTGCTCCTGTGGGCGAACCATTACACCCAAATCGAGACGCTGGATTTTACGGGTAACATCGCCGAC
TGGCGAGCCCTGTTGCCACTTTTTGGCGCCTTGTTGATCTGGATTGTCGCCAAACTCGGCTCCAAACGTTACAAGCGCAT
GGGGATTGCCTATGTATTACATAGGGTTAAATTGCACTATGGCAAAATTCCACTGCAATCTGCCGCAGGGCAATTTTTTC
AGGCGCTGTTTGCCTTAGGCACCAATTTCTCGGTAGGACGCGAAGGTCCCGCCATTCACCTCGGCGCCGTAAGTGCCAGT
GTTTTAGCCGAAAAATTTAATCTTCCCGACAATAGTGTGCGCATAATGTGCGCCAGCGGCATTGCAGCAGGGATTGCGGC
CACCTTTAACGCCCCGCTCGCGGCAGTGATATTTGTACTCGAAGTGATAGTGCGCGAATACAAGGTGCATTACTTCTTCC
CGATTATGCTGTCCGCGATTTGTGGTGCGGTTTCCAGCCAGTTGGTTTTTGGTAATGTGCACGAGTTTGACCGCATTCAG
GTGATCCATATTCCATTAGATCACTATCCCATTTTAGCCTTGGGCGGCATTGCACTGGGCTGCGCCGCCGCCTTCTTCAA
CTACGCGCTCCTTAAAGTCACCGCCACAGGGCAAAACTGGCCACTGATTTATCGGCTATTACTGGCGGGCAGTATCACTA
CACTGATTGGTTTAATCTTGCCTCAAGCCCTCGGCACTGGGGATTTGGCCATCAGTGAAGCCATCAGCGAGCATCCTAGT
TTATTGCTACTCATCGCCCTGCTTGCGGCCAAGATTATCGCCACCATAGCGGCAATCGGACTTGGGATCCCAGGCGGTTT
GATTGGTCCACTCTACGGCATTGGCGCCTTGATCGGTGCCATCTTAGCTTTAGTTAGCGCCATTCTATTCCCTTCGATTG
CACCTTACGTTGGCCTCTATACGGTTATCGGCATGACGGCGATGATGGGGGTTTGCCTCAGTGCGCCGCTCGCCGCCCTA
GTAGCGCTACTTGAGATGACCAACGATGCCAGTATCATTCTGCCAGCGATGTTTGTGACTATTCCCGCCTTCTTAATTGC
CTATCAAGGTTTTAAAACCAACTCTATTTTCTTCAAGCAGTTAGAGATTATGGGCTTAGGCTATAAAGTCGCCCCGGTGA
ATCTGGCGCTACAGAAAAAAGGCGTGCGCGCCCTGATGGATAAACGTTTTGTTATCGTCAACAACAACGACGAGCTGCTG
CTCGAAGTGTTAAAACGCGCCGAAGGTCGCCCAGTGTTAGTGCGTAACGCCGATGGGGTGATTGAAATGCTCAGCCTCGA
GATGCAATCCTACGATGACAACATCACCCTCTCACGCCATCCGATGCAGGGGCTGAGTGACACTAAAACCCTCGATGAGG
TGTATAACTTGTTGTCGCCCAAACGCAGTGGTGAGGTATTTATCTACCAAGACACCCCAGACAATGTGGTAGGAGTGGTC
AGTTGGTCGAACCTACAACAGGAAATTCGCTCCGGCCAAGTCTAA

Upstream 100 bases:

>100_bases
TCTAGCCAACGATGATAATTTGGCATTAGGTAACAGCCCCTTATATAAAATACAATCAACTCAAGAACGAGTTCGATACA
ATACAACTCAGGCCAATGCA

Downstream 100 bases:

>100_bases
GTTCTGCAAAGATGGGCTTAGATTCACAAAATCCTGTATTAGCTGCTTAAAAAATCTATACGAAGGTGCGGCGACTATTT
CGCTGCCCCTGTGCATCTGT

Product: Cl- channel, voltage-gated family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MQLTINKAAIQDAISTAKKYLTNELRDHLSQAKISAQLCLLALLFAIFASCVILLFRLLLLWANHYTQIETLDFTGNIAD
WRALLPLFGALLIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAAGQFFQALFALGTNFSVGREGPAIHLGAVSAS
VLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILALGGIALGCAAAFFNYALLKVTATGQNWPLIYRLLLAGSITTLIGLILPQALGTGDLAISEAISEHPS
LLLLIALLAAKIIATIAAIGLGIPGGLIGPLYGIGALIGAILALVSAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDNITLSRHPMQGLSDTKTLDEVYNLLSPKRSGEVFIYQDTPDNVVGVV
SWSNLQQEIRSGQV

Sequences:

>Translated_574_residues
MQLTINKAAIQDAISTAKKYLTNELRDHLSQAKISAQLCLLALLFAIFASCVILLFRLLLLWANHYTQIETLDFTGNIAD
WRALLPLFGALLIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAAGQFFQALFALGTNFSVGREGPAIHLGAVSAS
VLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILALGGIALGCAAAFFNYALLKVTATGQNWPLIYRLLLAGSITTLIGLILPQALGTGDLAISEAISEHPS
LLLLIALLAAKIIATIAAIGLGIPGGLIGPLYGIGALIGAILALVSAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDNITLSRHPMQGLSDTKTLDEVYNLLSPKRSGEVFIYQDTPDNVVGVV
SWSNLQQEIRSGQV
>Mature_574_residues
MQLTINKAAIQDAISTAKKYLTNELRDHLSQAKISAQLCLLALLFAIFASCVILLFRLLLLWANHYTQIETLDFTGNIAD
WRALLPLFGALLIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAAGQFFQALFALGTNFSVGREGPAIHLGAVSAS
VLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILALGGIALGCAAAFFNYALLKVTATGQNWPLIYRLLLAGSITTLIGLILPQALGTGDLAISEAISEHPS
LLLLIALLAAKIIATIAAIGLGIPGGLIGPLYGIGALIGAILALVSAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDNITLSRHPMQGLSDTKTLDEVYNLLSPKRSGEVFIYQDTPDNVVGVV
SWSNLQQEIRSGQV

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=294, Percent_Identity=28.2312925170068, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081943, Length=295, Percent_Identity=26.4406779661017, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62041; Mature: 62041

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTINKAAIQDAISTAKKYLTNELRDHLSQAKISAQLCLLALLFAIFASCVILLFRLLL
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWANHYTQIETLDFTGNIADWRALLPLFGALLIWIVAKLGSKRYKRMGIAYVLHRVKLHY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKIPLQSAAGQFFQALFALGTNFSVGREGPAIHLGAVSASVLAEKFNLPDNSVRIMCASG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECC
IAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VIHIPLDHYPILALGGIALGCAAAFFNYALLKVTATGQNWPLIYRLLLAGSITTLIGLIL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PQALGTGDLAISEAISEHPSLLLLIALLAAKIIATIAAIGLGIPGGLIGPLYGIGALIGA
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILALVSAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLEMTNDASIILPAMFVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHH
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDNITLSRHPMQGLSDTKTLDEVYNLLSP
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCC
KRSGEVFIYQDTPDNVVGVVSWSNLQQEIRSGQV
CCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure
MQLTINKAAIQDAISTAKKYLTNELRDHLSQAKISAQLCLLALLFAIFASCVILLFRLLL
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWANHYTQIETLDFTGNIADWRALLPLFGALLIWIVAKLGSKRYKRMGIAYVLHRVKLHY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKIPLQSAAGQFFQALFALGTNFSVGREGPAIHLGAVSASVLAEKFNLPDNSVRIMCASG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECC
IAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VIHIPLDHYPILALGGIALGCAAAFFNYALLKVTATGQNWPLIYRLLLAGSITTLIGLIL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PQALGTGDLAISEAISEHPSLLLLIALLAAKIIATIAAIGLGIPGGLIGPLYGIGALIGA
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILALVSAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLEMTNDASIILPAMFVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHH
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDNITLSRHPMQGLSDTKTLDEVYNLLSP
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCC
KRSGEVFIYQDTPDNVVGVVSWSNLQQEIRSGQV
CCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA