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The map label for this gene is nhaA [H]

Identifier: 117921477

GI number: 117921477

Start: 3641862

End: 3643031

Strand: Reverse

Name: nhaA [H]

Synonym: Shewana3_3038

Alternate gene names: 117921477

Gene position: 3643031-3641862 (Counterclockwise)

Preceding gene: 117921478

Following gene: 117921476

Centisome position: 73.27

GC content: 49.66

Gene sequence:

>1170_bases
ATGGAAAAAGCAATTAGAAATTTTCTGAGCCAGGAATCGGCTGGCGGCATCCTGTTATTGGTTGCTGTTGTCTTAGCCAT
GCTCATGGCCAATTCTCCTCTAGCGGGACTCTATCAAGGTTTTCTCGGTACTGAAGTACAAGTGCGTGTCGGCGCGCTCG
ATCTGCATAAGCCGCTGTTACTGTGGATTAACGATGGCCTGATGGCATTGTTTTTCTTACTGATTGGCTTAGAGGTGAAG
CGTGAACTGTTAGAAGGCGCCTTATCCAGTGTCGCTCAGGCCTCACTGCCAACCTTCGCTGCGATTGGTGGTATGTTAGT
GCCTGCTGGCATCTATCTGCTATTTAACTATGGCGATCCTGTGACCCAAGTGGGTTGGGCCATTCCTGCGGCTACCGATA
TTGCGTTTGCACTCGGCATCATGGCGTTGCTGGGTAGCCGCGTGCCAGTGGCATTGAAGGTCTTCCTGCTGGCGCTCGCT
ATCATCGATGACTTAGGCGTGATTGTGATTATTGCGCTCTTCTACAGCAGCGATCTGTCAACCATTAGCTTAATTATTGC
CAGCATTGCGATTGTCGGTTTAGTGGCCTTAAACCGTAAAGGCGTGACCGCATTAGCACCCTATGGCGTGTTGGGACTCG
TCCTGTGGGTCGCGGTATTGAAGTCAGGCGTCCACGCGACTTTGGCAGGTGTGATTATTGCCTTCTGTATTCCACTGCGG
GCAAAGGATGGCAGTTCACCCTCTGAGCATTTAGAGCATAGCCTGCACCCTTGGAGCACTTTCCTTATCCTGCCTGTTTT
TGCCTTTGCGAATGCAGGGGTGGCCTTAGGTAACATGAGTTTGGATGCCCTAATTTCCCCAGTACCCGTTGGGATTGCAT
TGGGACTCATGTTAGGTAAGCCGATTGGTGTAATGTTGTTTAGTTATGTGGCCGTCAAACTGAAGTTGGCGCAATTACCC
GATGGAATTGGTTGGAAGCAGATTGCGCCAGTGGCGGCAATGTGTGGTATTGGTTTTACTATGTCGATGTTTATTGCTTC
GCTTGCATTTGAGCAAGCAGACCCTATGTTCGGCGACTTAGCACGCCTTGGCACCTTGATAGGCTCAATTCTAGCGGCCT
TGATCGGGTATTTCTGGTTATCAAAAGTGTTACCTAAAAAAGGAGTATAA

Upstream 100 bases:

>100_bases
ACACCTCGGAATTATCGAGGTGTTTTGTCGAAACTATCGATTATACTTGTTTTTTTTCTTCGTCTACACTCAGTTCATTA
TGATTTTTTTGGAGTGCAAG

Downstream 100 bases:

>100_bases
CTATGATAAATATGAAATTAGTAGGAATGGCAGCACTGTTAACACTTTCTTCAAGCGCAATGGCTTCGCAGATTGATGCC
TGTAACAAGGATGTCGCATC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MEKAIRNFLSQESAGGILLLVAVVLAMLMANSPLAGLYQGFLGTEVQVRVGALDLHKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGIYLLFNYGDPVTQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVIVIIALFYSSDLSTISLIIASIAIVGLVALNRKGVTALAPYGVLGLVLWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEHLEHSLHPWSTFLILPVFAFANAGVALGNMSLDALISPVPVGIALGLMLGKPIGVMLFSYVAVKLKLAQLP
DGIGWKQIAPVAAMCGIGFTMSMFIASLAFEQADPMFGDLARLGTLIGSILAALIGYFWLSKVLPKKGV

Sequences:

>Translated_389_residues
MEKAIRNFLSQESAGGILLLVAVVLAMLMANSPLAGLYQGFLGTEVQVRVGALDLHKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGIYLLFNYGDPVTQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVIVIIALFYSSDLSTISLIIASIAIVGLVALNRKGVTALAPYGVLGLVLWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEHLEHSLHPWSTFLILPVFAFANAGVALGNMSLDALISPVPVGIALGLMLGKPIGVMLFSYVAVKLKLAQLP
DGIGWKQIAPVAAMCGIGFTMSMFIASLAFEQADPMFGDLARLGTLIGSILAALIGYFWLSKVLPKKGV
>Mature_389_residues
MEKAIRNFLSQESAGGILLLVAVVLAMLMANSPLAGLYQGFLGTEVQVRVGALDLHKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGIYLLFNYGDPVTQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVIVIIALFYSSDLSTISLIIASIAIVGLVALNRKGVTALAPYGVLGLVLWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEHLEHSLHPWSTFLILPVFAFANAGVALGNMSLDALISPVPVGIALGLMLGKPIGVMLFSYVAVKLKLAQLP
DGIGWKQIAPVAAMCGIGFTMSMFIASLAFEQADPMFGDLARLGTLIGSILAALIGYFWLSKVLPKKGV

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=380, Percent_Identity=60.7894736842105, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40709; Mature: 40709

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAIRNFLSQESAGGILLLVAVVLAMLMANSPLAGLYQGFLGTEVQVRVGALDLHKPLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHCCCHH
LWINDGLMALFFLLIGLEVKRELLEGALSSVAQASLPTFAAIGGMLVPAGIYLLFNYGDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCC
VTQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALAIIDDLGVIVIIALFYSSDLS
HHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
TISLIIASIAIVGLVALNRKGVTALAPYGVLGLVLWVAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEHLEHSLHPWSTFLILPVFAFANAGVALGNMSLDALISPVPVGIALGLMLGK
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHCCHHHHHHHHHHHCC
PIGVMLFSYVAVKLKLAQLPDGIGWKQIAPVAAMCGIGFTMSMFIASLAFEQADPMFGDL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARLGTLIGSILAALIGYFWLSKVLPKKGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKAIRNFLSQESAGGILLLVAVVLAMLMANSPLAGLYQGFLGTEVQVRVGALDLHKPLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHCCCHH
LWINDGLMALFFLLIGLEVKRELLEGALSSVAQASLPTFAAIGGMLVPAGIYLLFNYGDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCC
VTQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALAIIDDLGVIVIIALFYSSDLS
HHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
TISLIIASIAIVGLVALNRKGVTALAPYGVLGLVLWVAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEHLEHSLHPWSTFLILPVFAFANAGVALGNMSLDALISPVPVGIALGLMLGK
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHCCHHHHHHHHHHHCC
PIGVMLFSYVAVKLKLAQLPDGIGWKQIAPVAAMCGIGFTMSMFIASLAFEQADPMFGDL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARLGTLIGSILAALIGYFWLSKVLPKKGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA