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The map label for this gene is kefC [H]

Identifier: 117921385

GI number: 117921385

Start: 3538401

End: 3540170

Strand: Reverse

Name: kefC [H]

Synonym: Shewana3_2945

Alternate gene names: 117921385

Gene position: 3540170-3538401 (Counterclockwise)

Preceding gene: 117921386

Following gene: 117921383

Centisome position: 71.2

GC content: 51.58

Gene sequence:

>1770_bases
ATGGAAGAGTCGAGTCTGCTCACTTCTGTACTGTTATTTTTATTGGCCGCGGTGATTTTTGTGCCCTTGGGCAAACGTTT
TGGCGCAGGACCGATTCTGTCTTACCTCGCTGCCGGGGTGATTTTAGGCCCCGGAGGCATGGCGCTGGTGTCTGATCCCG
CCGCCGTGCTGCATTTTGCTGAGTTGGGTGTGGTACTGATGCTGTTTGTGCTTGGGCTTGAACTCAATCCGAGCAAGTTA
TGGGAGCTACGCAGTGCCATCTTTGGTCTCGGTAGTGGTCAGTTACTCCTTTCTTGGGCGGCAATTGGCGGTTTAGCTTG
GGGGTTTGGCTTATCCATTGAGGCTGCATTAGTGGTTGGCGCGGCGTTATCCTTGTCATCGACGGCTTTTGCGGTGCAGT
TGATGAGCGAACATAGACTGCTGACCACCCCGCTGGGCCGCGATGCCTTTGGGGTGTTGTTAATGCAAGATCTCGCCGTG
ATCCCCATGTTGCTATTAACCGCTTACCTTGCGCCTAATTCGGCCCAGATTGAGCACCATGCGGTACCTTGGTATTGGAC
CAGTGTGGCCTTAGTGGGCTTTGTGTTGGTAGGCAAATATCTGTTGCCGCGGTTACTTAAACTCGTTGCCAGCAGCGGGG
TTCGTGAAGTGTTAACCGCCTTTGCACTATTGCTGGTGATGGGCAGTGCCGAATTGATGGAGTGGCTGGGGCTATCGGCG
GGTATGGGGGCGTTTTTAGCCGGAATTATGCTGGCGAACTCCAGCTACCGACATCAGCTTGAAACCGATATTGAACCTTT
TAAGGGCTTACTGCTTGGGCTGTTTTTTATGGCCGTGGGCATGAGTATGGATCTCAAGCTGTTTTTAACCGATCCCTTAC
TCATACTTGCGATTTTGCTGGGCATGTTACTGATTAAGACTCTCGTGCTGATGCTCCTTGGCCGTTTACGACATCATGCA
TGGCGCCCGAGTATTGCTCTAGGCCTTATCTTGGCCGAAGGCGGTGAGTTTGCCTTCGTGCTGCTGTCGCAGGCGCAATT
ATCCAGCATAGTGGATGATAAAATCGCCCAAATCTTAGTGCTCGCCATCGGTTTATCCATGGCAGTCACGCCGATGATTT
TCACGCTTTTTAGAGCCACTAAACCTAAGGTGGTGGATACACGTTTGCCCGATACCATTAATGTGACTGAATCTGAGGTG
GTGATCGCCGGATTTGGGCGGGTGGGGCAGATCACTGGGCGTATTTTAGCGTCATCGGGTATTCCGTTTGTGGCCTTAGA
TAAGGATGCCAGCCATGTGGATGTGATCCGCAAATACGGTGGTGAGGTCTATTTTGGCGATGCCAGACGTTTAGATATGT
TGATGTCTGCGGGGATTGCACGCTCGCGCCTGTTGCTGCTGGCTGTTGATAATGTTGAGGATTCGATTGAAATTGCCCAG
CAGGTGAAAACCCATTTCCCCCATATCAATATCGTCGCTCGGGCGCGGGACCGTAACCATGCCTATCGATTGATGAGCCT
TGGGGTGACCGATGTGTTCCGTGAAACCTTTGGTTCGGCTTTATCCGCCAGTGAGAAGATTTTGCAGGGCTTAGGCTTAT
CGCAGGTGCAAGCCAATGAACGGGTGAAGATTTTTGCCGAGCACGATAAAAAGCTGGTGATAGCCAGCTCGGCCCATCAA
CATGATTTAGCCAAGCTCCTTGATTTATCCAATAAAGGAAAAGCTGAGTTGGAGTCGCTGATGCGTGGCGACCGGGAGAA
TGTCAGTTAA

Upstream 100 bases:

>100_bases
TTTCCTGCCTAACTAGAGTATGATTGCCAGCGGTAGCCGAAGCTTTTTTTGCTTATGGCTATACCTATTTTTTGCCTTTC
GCTAACGTTGTGGAGCCCTA

Downstream 100 bases:

>100_bases
GTCAGCTGGCTAAAACAAACAAGAGAGCCGATGGGCTCTCTTGTTGTTTATGGGCTTAAGGAAAACGCTTAGAAACTGTA
GCTATATTGCAGCTTCACAT

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MEESSLLTSVLLFLLAAVIFVPLGKRFGAGPILSYLAAGVILGPGGMALVSDPAAVLHFAELGVVLMLFVLGLELNPSKL
WELRSAIFGLGSGQLLLSWAAIGGLAWGFGLSIEAALVVGAALSLSSTAFAVQLMSEHRLLTTPLGRDAFGVLLMQDLAV
IPMLLLTAYLAPNSAQIEHHAVPWYWTSVALVGFVLVGKYLLPRLLKLVASSGVREVLTAFALLLVMGSAELMEWLGLSA
GMGAFLAGIMLANSSYRHQLETDIEPFKGLLLGLFFMAVGMSMDLKLFLTDPLLILAILLGMLLIKTLVLMLLGRLRHHA
WRPSIALGLILAEGGEFAFVLLSQAQLSSIVDDKIAQILVLAIGLSMAVTPMIFTLFRATKPKVVDTRLPDTINVTESEV
VIAGFGRVGQITGRILASSGIPFVALDKDASHVDVIRKYGGEVYFGDARRLDMLMSAGIARSRLLLLAVDNVEDSIEIAQ
QVKTHFPHINIVARARDRNHAYRLMSLGVTDVFRETFGSALSASEKILQGLGLSQVQANERVKIFAEHDKKLVIASSAHQ
HDLAKLLDLSNKGKAELESLMRGDRENVS

Sequences:

>Translated_589_residues
MEESSLLTSVLLFLLAAVIFVPLGKRFGAGPILSYLAAGVILGPGGMALVSDPAAVLHFAELGVVLMLFVLGLELNPSKL
WELRSAIFGLGSGQLLLSWAAIGGLAWGFGLSIEAALVVGAALSLSSTAFAVQLMSEHRLLTTPLGRDAFGVLLMQDLAV
IPMLLLTAYLAPNSAQIEHHAVPWYWTSVALVGFVLVGKYLLPRLLKLVASSGVREVLTAFALLLVMGSAELMEWLGLSA
GMGAFLAGIMLANSSYRHQLETDIEPFKGLLLGLFFMAVGMSMDLKLFLTDPLLILAILLGMLLIKTLVLMLLGRLRHHA
WRPSIALGLILAEGGEFAFVLLSQAQLSSIVDDKIAQILVLAIGLSMAVTPMIFTLFRATKPKVVDTRLPDTINVTESEV
VIAGFGRVGQITGRILASSGIPFVALDKDASHVDVIRKYGGEVYFGDARRLDMLMSAGIARSRLLLLAVDNVEDSIEIAQ
QVKTHFPHINIVARARDRNHAYRLMSLGVTDVFRETFGSALSASEKILQGLGLSQVQANERVKIFAEHDKKLVIASSAHQ
HDLAKLLDLSNKGKAELESLMRGDRENVS
>Mature_589_residues
MEESSLLTSVLLFLLAAVIFVPLGKRFGAGPILSYLAAGVILGPGGMALVSDPAAVLHFAELGVVLMLFVLGLELNPSKL
WELRSAIFGLGSGQLLLSWAAIGGLAWGFGLSIEAALVVGAALSLSSTAFAVQLMSEHRLLTTPLGRDAFGVLLMQDLAV
IPMLLLTAYLAPNSAQIEHHAVPWYWTSVALVGFVLVGKYLLPRLLKLVASSGVREVLTAFALLLVMGSAELMEWLGLSA
GMGAFLAGIMLANSSYRHQLETDIEPFKGLLLGLFFMAVGMSMDLKLFLTDPLLILAILLGMLLIKTLVLMLLGRLRHHA
WRPSIALGLILAEGGEFAFVLLSQAQLSSIVDDKIAQILVLAIGLSMAVTPMIFTLFRATKPKVVDTRLPDTINVTESEV
VIAGFGRVGQITGRILASSGIPFVALDKDASHVDVIRKYGGEVYFGDARRLDMLMSAGIARSRLLLLAVDNVEDSIEIAQ
QVKTHFPHINIVARARDRNHAYRLMSLGVTDVFRETFGSALSASEKILQGLGLSQVQANERVKIFAEHDKKLVIASSAHQ
HDLAKLLDLSNKGKAELESLMRGDRENVS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=407, Percent_Identity=27.027027027027, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786232, Length=590, Percent_Identity=43.5593220338983, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789749, Length=598, Percent_Identity=40.9698996655518, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1786685, Length=529, Percent_Identity=28.3553875236295, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63398; Mature: 63398

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESSLLTSVLLFLLAAVIFVPLGKRFGAGPILSYLAAGVILGPGGMALVSDPAAVLHFA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCCEEECCHHHHHHHH
ELGVVLMLFVLGLELNPSKLWELRSAIFGLGSGQLLLSWAAIGGLAWGFGLSIEAALVVG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
AALSLSSTAFAVQLMSEHRLLTTPLGRDAFGVLLMQDLAVIPMLLLTAYLAPNSAQIEHH
HHHHHCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AVPWYWTSVALVGFVLVGKYLLPRLLKLVASSGVREVLTAFALLLVMGSAELMEWLGLSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCC
GMGAFLAGIMLANSSYRHQLETDIEPFKGLLLGLFFMAVGMSMDLKLFLTDPLLILAILL
CHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
GMLLIKTLVLMLLGRLRHHAWRPSIALGLILAEGGEFAFVLLSQAQLSSIVDDKIAQILV
HHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHH
LAIGLSMAVTPMIFTLFRATKPKVVDTRLPDTINVTESEVVIAGFGRVGQITGRILASSG
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCC
IPFVALDKDASHVDVIRKYGGEVYFGDARRLDMLMSAGIARSRLLLLAVDNVEDSIEIAQ
CCEEEECCCCHHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHEEEEEEECCCHHHHHHHH
QVKTHFPHINIVARARDRNHAYRLMSLGVTDVFRETFGSALSASEKILQGLGLSQVQANE
HHHHHCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
RVKIFAEHDKKLVIASSAHQHDLAKLLDLSNKGKAELESLMRGDRENVS
CEEEEEECCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEESSLLTSVLLFLLAAVIFVPLGKRFGAGPILSYLAAGVILGPGGMALVSDPAAVLHFA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCCEEECCHHHHHHHH
ELGVVLMLFVLGLELNPSKLWELRSAIFGLGSGQLLLSWAAIGGLAWGFGLSIEAALVVG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
AALSLSSTAFAVQLMSEHRLLTTPLGRDAFGVLLMQDLAVIPMLLLTAYLAPNSAQIEHH
HHHHHCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AVPWYWTSVALVGFVLVGKYLLPRLLKLVASSGVREVLTAFALLLVMGSAELMEWLGLSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCC
GMGAFLAGIMLANSSYRHQLETDIEPFKGLLLGLFFMAVGMSMDLKLFLTDPLLILAILL
CHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
GMLLIKTLVLMLLGRLRHHAWRPSIALGLILAEGGEFAFVLLSQAQLSSIVDDKIAQILV
HHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHH
LAIGLSMAVTPMIFTLFRATKPKVVDTRLPDTINVTESEVVIAGFGRVGQITGRILASSG
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCC
IPFVALDKDASHVDVIRKYGGEVYFGDARRLDMLMSAGIARSRLLLLAVDNVEDSIEIAQ
CCEEEECCCCHHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHEEEEEEECCCHHHHHHHH
QVKTHFPHINIVARARDRNHAYRLMSLGVTDVFRETFGSALSASEKILQGLGLSQVQANE
HHHHHCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
RVKIFAEHDKKLVIASSAHQHDLAKLLDLSNKGKAELESLMRGDRENVS
CEEEEEECCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA