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The map label for this gene is mepA [H]

Identifier: 117921363

GI number: 117921363

Start: 3502723

End: 3504075

Strand: Reverse

Name: mepA [H]

Synonym: Shewana3_2923

Alternate gene names: 117921363

Gene position: 3504075-3502723 (Counterclockwise)

Preceding gene: 117921365

Following gene: 117921362

Centisome position: 70.47

GC content: 50.85

Gene sequence:

>1353_bases
ATGACTGCAATTTCCCATAGCGCAACGGACCAACGCCTGCTGCAAGAGCCGATTGCTAAGCTTTTCTGGCGCTATACCAT
TCCAACGATCGCCTCCATGCTGGTGACAGGGGTGTATGTCACCATTGATGGTATTTTCGTTGGTCATTATCTTGGCGAAA
CCGGGCTGGCGGGTATGATGCTGGCCTATCCCGTGGGCGCGATTCTCTATGCCGTCGGCGCTATGATAGGCATGGGCAGC
GCGGCGTTAGTCTCAATTAACTTAGGGCAAGGTCATGTCGCCAAGGCGCGTAAGTTGCTCGGCAATGCCTTTAGTTTATG
TTTACTGGCGGGGGCATTTTTTGCCTTAATCGGCGGGATCTTTTCTCGGGATATTTTAATTGCCCTTGGCGCCGAGGGGG
AGATACTCGAAAACGCTAATGAATACTTGTTCTGGTATTTTGCTCTATGCCATTTCCCTATTATTTCAATGGCATTTACC
ACCTTGCTGCGTAACGACGGTCGCCCCTCCATGGTGACCTTTGTGCTGATTTTAGGTGGCGTGCTGAACACCTTTTTAGA
TTGGCTGTTTATTGTGGTGTTTCCCTTTGGTTTGGCCGGAGCGGCGATTGCCACCATGTTGTCCCAGGCCGTGACTGGTT
TACTCTGCCTGCAGCATTTTTTTGGGGCGCGCACTCAGCTCAAAATCAATCTTGAGCAGATGAAGCTAAAACTCGATAAC
TGCCTCAATATTGCCCGTGTTGGCTTGCCAAGTTTTTTGATGAACCTGTATTTGTCGATTGTATTGACCCTGCATAACAC
CGCCTTTTTATGGGTCGGCGGTCCTCTGCATGTGGCGGCATACGGGGTGGTGAGTTACACCGAAGCGTTTTTCTATCTGA
TTTTTGAAGGCATTGCCCTCGGCACTCAACCGATTTACAGCTTTAATGCGGGGGCAGGGCGCTTCGACAGGGTTAAGCAG
GCACGCAATATCGCCTTTGGCATGACCCTACTCACCGCTGGACTCTGCTTAGTGTTGATTTATTCCCGCCCCGAATGGTT
GGTATACCTATTTGCCGGTGACAACCCAAGCTTAACGCCGGTCGCGATTGAAGGCATGCGTTGGTATTTCTGGGGCTTAC
CGATGGAAGGCTTGATTCTTGTGGGCGCCAGTTTCTTCCAAGCGATTAATTGTTCTAAACAGGCCTCGATACTCACAGGG
GCGAAACTGCTGCTTATCGCCGCCATTATCTATTGTTTTGCCTGGGCCTTTGGCGTGATTGGCGTGTGGGTGTCGCTTGC
GACCTGTAGCACTATGCTGGTGATTTGGATGTTTATCGCGATGGGGCGGCTCCAAGTGAACGCTAAAGTCTGA

Upstream 100 bases:

>100_bases
TTCATCCACTATTTTATCTGTGCGAATACAGCTTATCTGTGTGAATACAGTCAGAATACTGTGAGTGCGAGCCCTGCCTT
TATTTTTGTGAGATTAGGTT

Downstream 100 bases:

>100_bases
TGTTGTTTACGCATTATCTTTACCTTCGAAACCGACTTAGTACTGGCGTGTCGGCATGCGCTCTGTTACATTTCGCTGGT
TTAATCCCAGCTTAAATTTA

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMMLAYPVGAILYAVGAMIGMGS
AALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGIFSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFT
TLLRNDGRPSMVTFVLILGGVLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDN
CLNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIALGTQPIYSFNAGAGRFDRVKQ
ARNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTPVAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTG
AKLLLIAAIIYCFAWAFGVIGVWVSLATCSTMLVIWMFIAMGRLQVNAKV

Sequences:

>Translated_450_residues
MTAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMMLAYPVGAILYAVGAMIGMGS
AALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGIFSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFT
TLLRNDGRPSMVTFVLILGGVLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDN
CLNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIALGTQPIYSFNAGAGRFDRVKQ
ARNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTPVAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTG
AKLLLIAAIIYCFAWAFGVIGVWVSLATCSTMLVIWMFIAMGRLQVNAKV
>Mature_449_residues
TAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMMLAYPVGAILYAVGAMIGMGSA
ALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGIFSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFTT
LLRNDGRPSMVTFVLILGGVLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDNC
LNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIALGTQPIYSFNAGAGRFDRVKQA
RNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTPVAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTGA
KLLLIAAIIYCFAWAFGVIGVWVSLATCSTMLVIWMFIAMGRLQVNAKV

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48971; Mature: 48840

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCHHHHH
LAYPVGAILYAVGAMIGMGSAALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFTTLLRNDGRPSMVTFVLILGG
HHCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
CLNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIAL
HHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
GTQPIYSFNAGAGRFDRVKQARNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTP
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
VAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTGAKLLLIAAIIYCFAWAFGVI
EEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVWVSLATCSTMLVIWMFIAMGRLQVNAKV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
TAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCHHHHH
LAYPVGAILYAVGAMIGMGSAALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFTTLLRNDGRPSMVTFVLILGG
HHCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
CLNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIAL
HHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
GTQPIYSFNAGAGRFDRVKQARNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTP
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
VAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTGAKLLLIAAIIYCFAWAFGVI
EEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVWVSLATCSTMLVIWMFIAMGRLQVNAKV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA