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The map label for this gene is glcA [C]

Identifier: 117921345

GI number: 117921345

Start: 3474335

End: 3475978

Strand: Direct

Name: glcA [C]

Synonym: Shewana3_2904

Alternate gene names: 117921345

Gene position: 3474335-3475978 (Clockwise)

Preceding gene: 117921344

Following gene: 117921346

Centisome position: 69.88

GC content: 49.15

Gene sequence:

>1644_bases
ATGACAATACTTCAACTCCTCGCCAGCTTGACGCCAGTAATCAGTGTAATGATCTTTCTCGTATTACTCAGAATGCCAGC
GTCCAAAGCTATGCCCATCTCCATGATAATCACAGCGCTGGCCGCCGTGTTTATTTGGCAAATGGATACCACACTATTAG
CCGCATCGGTTCTCGAAGGACTGCTGTCAGCCATCACCCCATTAACCATCATCTTCGGCGCGGTATTCCTGCTCAACACC
CTGAAATACTCAGGGGCAATGGATACCATCCGCGCGGGCTTCACTAACATCAGTGCCGACGCCCGTGTGCAGGTGATCAT
CATCTGTTGGTTATTCGGAGCCTTTATCGAAGGTAGTGCGGGCTTTGGGACGCCCGCCGCGATTGGTGCACCGCTGCTGG
TATTACTGGGCGTTCCACCAGTTGCCGCAGCCGTAGTGGCCTTGATTGCCGACTCAGCTTGTGTGTCCTTCGGTGCGATT
GGTTTACCCGTGCTATTTGGTATGGAGCAAGGTTTAACTCAAGGCGGTGTGAGCTTAGCAGCTGAACAGTTTGCAGCCCA
TGGCGGTAGCTACGTTGGTTATGCTCGCTTTATCGTGATGCATATGATCACTATCGACTTAATTACAGGTACCTTAATTC
CACTGGTCATGGTGACCATACTGACAGGATTCTTCGGCCGCAATAAATCTTTTAAAGAAGGTTTAGCGATTTGGAAATTT
GCGATTTTCGCCGGTCTTGCCTTTACCGTTCCTGCATGGATTATCAACTACCTTGCAGGTCCTGAATTCCCATCTGTTAT
CGGTTCATTGGTCGGTATGGCCTTAGTCATCCCTGTTGCGCGTAAAGGATACTTACTGCCCAAAACGCCTTGGAATGACT
TTGCCGAAAATGATAGCCAAGAAGGTGCAAAAATTGAGACGACTGCTAAGTTCTCACAAATTGCCGCTTGGACACCTTAT
ATCATCATGGCTGCGCTATTAGTGCTTTCACGCACTGTAGCACCACTCAAAGCCTGGTTATCTAGTTTCAACATCAGCTG
GACTGGCCTAATGGGCACTGAGCTTAAAGCCAGCTTTGCGACCTTATATGCTCCTGGCGCCTTCTTCGTGGCCGTGTGTA
TCTTAGGTTTCTTCCTGTTCAAGATGAAAAGCCCTGCGATTAAGCAATCCATCGGCGTTTCATGCAAGTCTATGTTACCG
ACTATTATTTCATTAGGCGCATCCGTGCCTATGGTGAAAATCTTCTTAAACTCAGGTGTTAATGGTGCAGGTCTTGCGTC
TATGCCCGTCGCCTTAGCCGATATGTTAGGCCAATCTATGGGCGCGGTTTGGGCATGGATGGCACCGATTGTGGGGATTT
TTGGTGCCTTCCTGTCAGGTTCAGCCACCTTCTCCAACATGATGTTCTCCAGCCTGCAATACAGCGTGGCGGACAATATT
GGCATGAACCATACACTGGTATTAGCACTACAAGGTATCGGTGCTAACGCCGGTAATATGATGTGTGTAATGAACGTAGT
GGCAGCCGCGACCGTTGTGGGTATGGCGGGTAGAGAATCTGAAATCATCCGTAAAACTATGCCTGTTGCCATTGGCTACG
CGTTACTTGCAGGCACTATCGCAACACTTTGGGGTGGCTTCTAA

Upstream 100 bases:

>100_bases
AGTGAAACCTGCTGATTTATCAGTCGGAGAGTCTGACAGGAAAACACTAGTAAGATCCAAATATAAATAATAAGACAGAC
CACTTTATGTAGAGGCAAGC

Downstream 100 bases:

>100_bases
GCCAATCTAAACCTAAGGCCGCGTTGGCGGCCTTAGTCATTTTTAGCGTTGAGAGAGTAACTTATGTCTATTAATTATGA
CGCTGTTTATAAAGAACTAA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTILQLLASLTPVISVMIFLVLLRMPASKAMPISMIITALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAI
GLPVLFGMEQGLTQGGVSLAAEQFAAHGGSYVGYARFIVMHMITIDLITGTLIPLVMVTILTGFFGRNKSFKEGLAIWKF
AIFAGLAFTVPAWIINYLAGPEFPSVIGSLVGMALVIPVARKGYLLPKTPWNDFAENDSQEGAKIETTAKFSQIAAWTPY
IIMAALLVLSRTVAPLKAWLSSFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQSIGVSCKSMLP
TIISLGASVPMVKIFLNSGVNGAGLASMPVALADMLGQSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSSLQYSVADNI
GMNHTLVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF

Sequences:

>Translated_547_residues
MTILQLLASLTPVISVMIFLVLLRMPASKAMPISMIITALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAI
GLPVLFGMEQGLTQGGVSLAAEQFAAHGGSYVGYARFIVMHMITIDLITGTLIPLVMVTILTGFFGRNKSFKEGLAIWKF
AIFAGLAFTVPAWIINYLAGPEFPSVIGSLVGMALVIPVARKGYLLPKTPWNDFAENDSQEGAKIETTAKFSQIAAWTPY
IIMAALLVLSRTVAPLKAWLSSFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQSIGVSCKSMLP
TIISLGASVPMVKIFLNSGVNGAGLASMPVALADMLGQSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSSLQYSVADNI
GMNHTLVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF
>Mature_546_residues
TILQLLASLTPVISVMIFLVLLRMPASKAMPISMIITALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNTL
KYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAIG
LPVLFGMEQGLTQGGVSLAAEQFAAHGGSYVGYARFIVMHMITIDLITGTLIPLVMVTILTGFFGRNKSFKEGLAIWKFA
IFAGLAFTVPAWIINYLAGPEFPSVIGSLVGMALVIPVARKGYLLPKTPWNDFAENDSQEGAKIETTAKFSQIAAWTPYI
IMAALLVLSRTVAPLKAWLSSFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQSIGVSCKSMLPT
IISLGASVPMVKIFLNSGVNGAGLASMPVALADMLGQSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSSLQYSVADNIG
MNHTLVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=580, Percent_Identity=29.1379310344828, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790031, Length=563, Percent_Identity=26.8206039076377, Blast_Score=145, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57312; Mature: 57181

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCC
>Mature Secondary Structure 
TILQLLASLTPVISVMIFLVLLRMPASKAMPISMIITALAAVFIWQMDTTLLAASVLEG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]