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The map label for this gene is uppS [H]

Identifier: 117921252

GI number: 117921252

Start: 3358518

End: 3359345

Strand: Reverse

Name: uppS [H]

Synonym: Shewana3_2811

Alternate gene names: 117921252

Gene position: 3359345-3358518 (Counterclockwise)

Preceding gene: 117921253

Following gene: 117921251

Centisome position: 67.56

GC content: 46.86

Gene sequence:

>828_bases
ATGTCATCCACAGTGGAATTTGATCCGCAATCTAGGTCGACTGAGCAGGATGCTTGTGCTCAGACAAGCTTACCGGAGGT
ATTACCCGAACTCGTAAAACAGTCATTACCTAAACATGTTGCGATTATTATGGATGGTAATGGACGTTGGGCCCAAACCC
AGGGCAAACCACGAGTGATGGGACATAAAGCCGGCGTAAAGGCGGTGAGACGTGCGGTGAGTGCGGCCAGTCAGTTAGGG
ATACAATCGCTGACGCTATTTGCGTTTTCCAGCGAGAATTGGCGTAGACCCGATAAAGAAGTCAGCTTGCTGATGGAATT
GTTTTTTACCGTGTTACAACGGGAAATTAAGTTACTCGATAAGAACCAAGTCAGATTGAATATCATCGGCGATATCAGCC
GTTTTTCTGCACGTTTACAAAAACAAATTCGTGCCGCAGAAGAAAAAACCGCAGGCAACAGTGGATTGATATTGAATGTA
GCGGCCAATTACGGTGGCCGTTGGGACATACTGCAAGCTGCGCAAAAGTTAGCTGAAAAGGTGGAAAATGGCGAAATGAC
CAGCAGTCAGTTCACCGAAGAAGCCTTGAGTGAACATTTGTGCATGCAAAATCAGAGTGAAGTTGATTTAATGATCCGTA
CGGGTGGGGATTACCGGATCAGCAATTTTGTGCTCTGGCAGGCTGCCTATGCTGAATTGGTGTTTATGGACACCCTTTGG
CCTGATTTCGATGAACAGGCTTTTCATGAAGCGATTGCCACTTTTGCCAGTCGCCAGCGCCGTTTTGGTTTGACCGGAAG
TCAAATTGATGAGATGCGCGCATTGTAA

Upstream 100 bases:

>100_bases
GAGTTGATGGAAGTCTAATCTCAGGCGCTATAAGCTAGAGTTGCTACGCCGTGTAGGGGTATACTACACGGCGTTTGTCT
ATTTTAAAGGGTTGTAATAG

Downstream 100 bases:

>100_bases
AACGTCATGAGGGATTTTTTTTGCTAAAACAACGTATAATAACAGCAATTTGGTTAATTCCATTAGTTTTGGGAGCGATC
TTTTTACTCCCCGTAGAGTA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSSTVEFDPQSRSTEQDACAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVMGHKAGVKAVRRAVSAASQLG
IQSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLDKNQVRLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNV
AANYGGRWDILQAAQKLAEKVENGEMTSSQFTEEALSEHLCMQNQSEVDLMIRTGGDYRISNFVLWQAAYAELVFMDTLW
PDFDEQAFHEAIATFASRQRRFGLTGSQIDEMRAL

Sequences:

>Translated_275_residues
MSSTVEFDPQSRSTEQDACAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVMGHKAGVKAVRRAVSAASQLG
IQSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLDKNQVRLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNV
AANYGGRWDILQAAQKLAEKVENGEMTSSQFTEEALSEHLCMQNQSEVDLMIRTGGDYRISNFVLWQAAYAELVFMDTLW
PDFDEQAFHEAIATFASRQRRFGLTGSQIDEMRAL
>Mature_274_residues
SSTVEFDPQSRSTEQDACAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVMGHKAGVKAVRRAVSAASQLGI
QSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLDKNQVRLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNVA
ANYGGRWDILQAAQKLAEKVENGEMTSSQFTEEALSEHLCMQNQSEVDLMIRTGGDYRISNFVLWQAAYAELVFMDTLWP
DFDEQAFHEAIATFASRQRRFGLTGSQIDEMRAL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=35.4260089686099, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=35.4260089686099, Blast_Score=137, Evalue=9e-33,
Organism=Escherichia coli, GI1786371, Length=243, Percent_Identity=60.9053497942387, Blast_Score=310, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=32.5991189427313, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=35.1851851851852, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=32.8888888888889, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=32.8947368421053, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30871; Mature: 30740

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTVEFDPQSRSTEQDACAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVM
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCHH
GHKAGVKAVRRAVSAASQLGIQSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLD
CHHHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
KNQVRLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNVAANYGGRWDILQAAQKLAEK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
VENGEMTSSQFTEEALSEHLCMQNQSEVDLMIRTGGDYRISNFVLWQAAYAELVFMDTLW
HHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCC
PDFDEQAFHEAIATFASRQRRFGLTGSQIDEMRAL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
SSTVEFDPQSRSTEQDACAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVM
CCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCHH
GHKAGVKAVRRAVSAASQLGIQSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLD
CHHHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
KNQVRLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNVAANYGGRWDILQAAQKLAEK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
VENGEMTSSQFTEEALSEHLCMQNQSEVDLMIRTGGDYRISNFVLWQAAYAELVFMDTLW
HHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCC
PDFDEQAFHEAIATFASRQRRFGLTGSQIDEMRAL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]