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The map label for this gene is acdA [H]

Identifier: 117921210

GI number: 117921210

Start: 3307341

End: 3308498

Strand: Reverse

Name: acdA [H]

Synonym: Shewana3_2769

Alternate gene names: 117921210

Gene position: 3308498-3307341 (Counterclockwise)

Preceding gene: 117921211

Following gene: 117921209

Centisome position: 66.54

GC content: 53.2

Gene sequence:

>1158_bases
ATGGATTTTAATTTCAACGAAGACCAACGCCAATTTGCCGATCTGGCCCGCCAGTTCGCGGCGGATGAACTCGCCCCCTT
CGCCGCCAAATGGGACGAAGAACATCATTTCCCTAAGGATGTGATCCAAAAAGCCGGTGAGCTGGGTTTCTGCTCCCTGT
ATTCCCCCGAATCGGAAGGTGGCATGGGCCTGTCGCGTTTAGATGCCTCGATTATTTTCGAAGAGCTATCGAAAGGCTGT
ACAGCCACAACAGCCATGCTGACGATTCACAATATGGCCACTTGGATGGTTACCACTTGGGGCACAGATACGCTGCGTCA
AGCTTGGTCTGAGCCCTTGACCACGGGCCAAATGCTGGCGTCTTACTGCTTAACTGAACCAGGTGCGGGCTCTGATGCGG
CATCACTGCAAACCAAAGCGGTGCGTGAGGGTGATGAATATGTGGTATCTGGCTCTAAGATGTTTATCTCGGGCGCAGGT
TCAACTGAGCTTTTAGTCGTAATGTGCCGCACTGGCCAAGCTGGGCCAAAGGGGATTTCGGCGATTGCCATTCCTGCCGA
CAGTGAAGGTATTATCTATGGCAAGGCCGAAGATAAGATGGGTTGGAACGCGCAGCCGACGCGCTTAGTTACCTTCGATA
ACGTGCGTGTACCCGTTGCGAACCTGCTCGGTGAAGAAGGCCAAGGTTTTACCTTTGCGATGAAAGGTTTAGACGGTGGT
CGTATCAATATCGCCACTTGCTCTGTCGGTACGGCGCAGGCGGCTTTGGAGCGTGCGACTCAGTACATGAATGAACGTCA
GCAATTTGGTAAGCCGCTGGCAGCCTTCCAAGCGCTGCAATTTAAGCTCGCCGATATGGCGACCGAATTAGTGGCCGCGC
GTCAAATGGTGCGTCTGGCCGCCTTTAAACTCGACAGTGGCGACCCAGAAGCGACCGCCTATTGCGCGATGGCGAAGCGT
TTTGCCACCGATGTGGGCTTCCAAGTTTGTGATGCCGCGCTGCAAATTCATGGCGGATATGGTTATATCAGGGAGTACCC
CTTAGAGCGTCACTTCCGTGATGTTCGCGTACATCAGATTTTAGAGGGCACTAACGAGATTATGCGCCTCATTATCGCCC
GTCGTTTACTCGACGAAAATGCCGGACAAATCCTCTAA

Upstream 100 bases:

>100_bases
AGTTGACGCCCATTGATGATAAGCCTGCTGATAAATTCACTGTGTATTACGCAAAAGATATTGACGAAAAGAAATGGCCA
AAGAGTCATAGGAGAGCCAA

Downstream 100 bases:

>100_bases
GCTGCCCAGATGGGACTATAGGATTTGGCGATAACCGATTGGAAATATAAGGGAGCCGAAACAGATGGAATATTTAGTTG
AGCGTATCGAAGGCCACACG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDFNFNEDQRQFADLARQFAADELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTDTLRQAWSEPLTTGQMLASYCLTEPGAGSDAASLQTKAVREGDEYVVSGSKMFISGAG
STELLVVMCRTGQAGPKGISAIAIPADSEGIIYGKAEDKMGWNAQPTRLVTFDNVRVPVANLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERATQYMNERQQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSGDPEATAYCAMAKR
FATDVGFQVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIIARRLLDENAGQIL

Sequences:

>Translated_385_residues
MDFNFNEDQRQFADLARQFAADELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTDTLRQAWSEPLTTGQMLASYCLTEPGAGSDAASLQTKAVREGDEYVVSGSKMFISGAG
STELLVVMCRTGQAGPKGISAIAIPADSEGIIYGKAEDKMGWNAQPTRLVTFDNVRVPVANLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERATQYMNERQQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSGDPEATAYCAMAKR
FATDVGFQVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIIARRLLDENAGQIL
>Mature_385_residues
MDFNFNEDQRQFADLARQFAADELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTDTLRQAWSEPLTTGQMLASYCLTEPGAGSDAASLQTKAVREGDEYVVSGSKMFISGAG
STELLVVMCRTGQAGPKGISAIAIPADSEGIIYGKAEDKMGWNAQPTRLVTFDNVRVPVANLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERATQYMNERQQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSGDPEATAYCAMAKR
FATDVGFQVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIIARRLLDENAGQIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=55.4666666666667, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=38.8451443569554, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=38.8451443569554, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=41.2868632707775, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.096256684492, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI21361497, Length=383, Percent_Identity=34.9869451697128, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=31.4814814814815, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.1170212765957, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI76496475, Length=387, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4557235, Length=387, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=31.547619047619, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI38505218, Length=372, Percent_Identity=28.7634408602151, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=26.4550264550265, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI48976061, Length=369, Percent_Identity=28.4552845528455, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI211971008, Length=369, Percent_Identity=28.4552845528455, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=26.1971830985915, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786223, Length=389, Percent_Identity=30.8483290488432, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=31.9480519480519, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082384, Length=302, Percent_Identity=28.1456953642384, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=52, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=39.4255874673629, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.5328083989501, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=37.434554973822, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=35.8090185676393, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=34.0425531914894, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=34.5609065155807, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=31.758530183727, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=358, Percent_Identity=30.4469273743017, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=35.7894736842105, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=29.8342541436464, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=37.9310344827586, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=31.8936877076412, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=28.3636363636364, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=382, Percent_Identity=27.2251308900524, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562446, Length=399, Percent_Identity=27.0676691729323, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=28.9795918367347, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531913, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=39.3139841688654, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=38.1818181818182, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.2978723404255, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=34.6774193548387, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.4647519582245, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=34.8973607038123, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=27.4151436031332, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42016; Mature: 42016

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNFNEDQRQFADLARQFAADELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDASIIFEELSKGCTATTAMLTIHNMATWMVTTWGTDTLRQAWSEPLTTGQMLA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHHHHH
SYCLTEPGAGSDAASLQTKAVREGDEYVVSGSKMFISGAGSTELLVVMCRTGQAGPKGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCCCEEEEEEECCCCCCCCCCE
AIAIPADSEGIIYGKAEDKMGWNAQPTRLVTFDNVRVPVANLLGEEGQGFTFAMKGLDGG
EEEECCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQAALERATQYMNERQQFGKPLAAFQALQFKLADMATELVAARQMVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDSGDPEATAYCAMAKRFATDVGFQVCDAALQIHGGYGYIREYPLERHFRDVRVHQI
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIIARRLLDENAGQIL
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFNFNEDQRQFADLARQFAADELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDASIIFEELSKGCTATTAMLTIHNMATWMVTTWGTDTLRQAWSEPLTTGQMLA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHHHHH
SYCLTEPGAGSDAASLQTKAVREGDEYVVSGSKMFISGAGSTELLVVMCRTGQAGPKGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCCCEEEEEEECCCCCCCCCCE
AIAIPADSEGIIYGKAEDKMGWNAQPTRLVTFDNVRVPVANLLGEEGQGFTFAMKGLDGG
EEEECCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQAALERATQYMNERQQFGKPLAAFQALQFKLADMATELVAARQMVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDSGDPEATAYCAMAKRFATDVGFQVCDAALQIHGGYGYIREYPLERHFRDVRVHQI
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIIARRLLDENAGQIL
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]