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The map label for this gene is clpP [H]

Identifier: 117921102

GI number: 117921102

Start: 3176846

End: 3177454

Strand: Reverse

Name: clpP [H]

Synonym: Shewana3_2661

Alternate gene names: 117921102

Gene position: 3177454-3176846 (Counterclockwise)

Preceding gene: 117921103

Following gene: 117921101

Centisome position: 63.9

GC content: 46.47

Gene sequence:

>609_bases
ATGCATAATGCGTCAGACATACAAAGTGCTTTAGTGCCTATGGTGATCGAACAGACGGCTAAGGGTGAACGCTCATTCGA
TATTTATTCTCGTCTGTTAAAAGAGCGGATTATCTTTTTAGTGGGTCAAGTTGAAGAGCATATGGCGAATCTGATTGTGG
CGCAGTTGCTATTCCTCGAGTCAGAAAGCCCAGATAAAGATATCTTCTTATATATCAACTCACCCGGTGGCTCAGTCACT
GCAGGTATGGCAATTTACGATACCATGCAGTTTATTAAGCCGAACGTCAGCACTGTGTGTATTGGTCAAGCGGCCAGCAT
GGGCGCGTTTTTATTAGCGGGCGGCGAAAAGGGCAAGCGTTTCTGCTTACCTAACTCTCGCGTGATGATCCACCAACCAC
TGGGTGGATTCCAAGGTCAGGCTTCTGATATTGCTATTCATGCCCAAGAGATCTTAGGCATCAAGCATAAACTGAATCTG
ATGTTGTCAGAGCACACTGGTCAGCCACTCGAAGTGATTGAACGTGATACCGACCGCGACAACTTCATGAGTGCGACTCA
AGCAGTTGAATATGGTTTAGTTGACGCAGTGATGACTAAACGCGGCTGA

Upstream 100 bases:

>100_bases
GTCGCGCATAAGCTAAGCTTGACTTGATTGGCAGTTCGCCATTTATAATGGCTCGTATGAGGCTCCTCATGCGAGCCATT
TTTATTTAGGGAAACGAATA

Downstream 100 bases:

>100_bases
TTTTTACTTTTGACTGGGCTATGCTCTATTTAAGCAAAGCCCCGTAAAGGGTTAGCAAGTTTAAGACAAGCAGTAGAGCA
GACTGCAAATGAGGTAATTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRFCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNL
MLSEHTGQPLEVIERDTDRDNFMSATQAVEYGLVDAVMTKRG

Sequences:

>Translated_202_residues
MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRFCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNL
MLSEHTGQPLEVIERDTDRDNFMSATQAVEYGLVDAVMTKRG
>Mature_202_residues
MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRFCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNL
MLSEHTGQPLEVIERDTDRDNFMSATQAVEYGLVDAVMTKRG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=54.5454545454545, Blast_Score=234, Evalue=4e-62,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=77.0833333333333, Blast_Score=326, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17538017, Length=200, Percent_Identity=55, Blast_Score=225, Evalue=9e-60,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=55.3191489361702, Blast_Score=228, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22154; Mature: 22154

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLE
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKR
CCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCE
FCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNLMLSEHTGQPLEVIERDTDRD
EECCCCEEEEECCCCCCCCCCCHHEEEHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCHH
NFMSATQAVEYGLVDAVMTKRG
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLE
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKR
CCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCE
FCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNLMLSEHTGQPLEVIERDTDRD
EECCCCEEEEECCCCCCCCCCCHHEEEHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCHH
NFMSATQAVEYGLVDAVMTKRG
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA