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The map label for this gene is adk [H]

Identifier: 117920884

GI number: 117920884

Start: 2927642

End: 2928286

Strand: Reverse

Name: adk [H]

Synonym: Shewana3_2441

Alternate gene names: 117920884

Gene position: 2928286-2927642 (Counterclockwise)

Preceding gene: 117920885

Following gene: 117920883

Centisome position: 58.89

GC content: 50.39

Gene sequence:

>645_bases
ATGCGCATTATCCTATTGGGCGCCCCAGGTGCCGGTAAAGGTACCCAGGCCCAGTTCATTATGGAACAGTATGGTATCCC
ACAAATTTCTACTGGCGACATGTTACGTGCTGCCGTTAAAGCCGGTACTCCGCTGGGTTTAGAAGCGAAGAAAGTGATGG
ATGCAGGCCAACTGGTTTCTGATGATCTGATCATTGGACTGGTTAAAGAGCGTATCGCACAGGACGACTGTGTTAAAGGT
TTCCTGTTAGACGGTTTCCCACGCACTATCCCACAAGCGGATGCGATGGCGGCAAACGGTATCAGCATTGATCACGTGAT
CGAAATCGATGTGCCAGACGAAGAAATCGTTAAGCGCATGAGCGGTCGTCGCGTTCACCCAGGTTCTGGCCGTGTTTACC
ACGTGGTATTCAATCCACCTAAAGTGGAAGGCAAGGACGATGTAACAGGCGAAGACTTAGCGATTCGTCCAGATGACGAA
GAAGCCACAGTGCGTAAGCGTTTAGGCATTTACCACGAGCAAACTAAGCCATTGGTTGAATACTATGGCAAAGTGGCTGC
GGCGGGTAACACTCAATACCACAAGTTCGATGGTACTCAGTCGGTAGCGGCTGTGAGTGCACAGTTAGCCAGCGTGCTGA
AATAA

Upstream 100 bases:

>100_bases
TGAGGCTAAAGTCGAAGCTAAAAGCCTTCTCAATGGCGGCCAGATGTGCGAAGATCGCCGCCCTAAGAAGAATATCAATG
CGAAAAAGAGGACTCTTGAG

Downstream 100 bases:

>100_bases
GCATCATTGCTAAATTCGAGAACAAGTTCTCATATTAGGAAAAAGCCTGCTATTGCAGGCTTTTTTTATTGGCGACCGAA
TGTTAGCCTGCCGAGGTATT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLGIYHEQTKPLVEYYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLGIYHEQTKPLVEYYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCVKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLGIYHEQTKPLVEYYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI19923437, Length=201, Percent_Identity=43.2835820895522, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=27.6699029126214, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=25.9433962264151, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=25.9433962264151, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=25.7918552036199, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=72.7699530516432, Blast_Score=318, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.8085106382979, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=187, Percent_Identity=34.7593582887701, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.967032967033, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=46.3302752293578, Blast_Score=204, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.8144329896907, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=185, Percent_Identity=28.6486486486486, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.0869565217391, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=30.939226519337, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=30.939226519337, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=25, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=25, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23064; Mature: 23064

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQDDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLGIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCHHHCCCHHHH
YYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK
HHHHHEECCCCEEEECCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQDDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLGIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCHHHCCCHHHH
YYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK
HHHHHEECCCCEEEECCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA