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The map label for this gene is hemH [H]

Identifier: 117920883

GI number: 117920883

Start: 2926516

End: 2927562

Strand: Reverse

Name: hemH [H]

Synonym: Shewana3_2440

Alternate gene names: 117920883

Gene position: 2927562-2926516 (Counterclockwise)

Preceding gene: 117920884

Following gene: 117920882

Centisome position: 58.88

GC content: 52.34

Gene sequence:

>1047_bases
ATGTTAGCCTGCCGAGGTATTTGGCTGATAAAAGGTAACACATTGACTTCTCCCTCTCCTGCGTTTGGCGTGTTATTGGT
CAATCTCGGCACGCCCGATGAACCCACTCCCAAAGCGGTTAAGCGATTCCTCAAACAGTTTTTAAGTGATCCTCGGGTCG
TCGATTTGTCCCCTTGGCTGTGGCAGCCGATTTTGCAAGGGATAATCCTTAACACCCGACCCGCCAAGGTGGCTAAACTT
TATCAGAGCGTGTGGACGGAGCAGGGCTCGCCGCTGATGGTGATAAGTGAGCAGCAGGCGCAAAAGTTAGCCACGGATCT
GAGCGCGACCTTTAATCAAACCATTCCGGTGGAACTCGGCATGAGCTATGGCAATCCTTCGATTGAGAGCGGCTTTGCCA
AACTCAAGGCCCAAGGCGCCGAACGTATCGTGGTGCTGCCGCTGTATCCGCAATATTCCTGCTCAACCGTCGCCAGTGTG
TTCGATGCGGTGGCGCAGTATTTTACTCAAGTGCGTGATATTCCTGAGCTGCGTTTTAGCAAACAGTATTTTGACCATGA
AGCCTATATCGCGGCTTTAGCGCATTCTGTGAAACGCCATTGGAAAACCCACGGGCAGGCCGACAAGTTGATTCTTTCCT
TCCACGGTATTCCGCTGCGGTATGCCACCGAAGGTGATCCCTATCCTGAGCAGTGCCGCGCGACGGCCAAGTTACTGGCG
CAGGCGCTGGAATTAACTGACGGACAATGGCAGGTGTGTTTCCAATCCCGCTTTGGCAAAGAAGAGTGGTTAACCCCCTA
TGCCGATGAGCTGCTGGCCGATTTACCCCGCCAAGGCGTAAAAAGTGTTGACGTCATTTGCCCTGCCTTTGCCACCGATT
GCCTTGAAACCTTAGAAGAAATTTCCATTGGCGGTAAAGAGACTTTCTTGCATGCGGGCGGCGAGGCCTATCACTTTATT
CCCTGTTTAAATGATGATGAGCTCCATATCGAGCTGCTCAGGCAACTGGTGCAAGAACAAGCTCAACCATGGATACGCGC
GGAGTGA

Upstream 100 bases:

>100_bases
TTAGCCAGCGTGCTGAAATAAGCATCATTGCTAAATTCGAGAACAAGTTCTCATATTAGGAAAAAGCCTGCTATTGCAGG
CTTTTTTTATTGGCGACCGA

Downstream 100 bases:

>100_bases
CGGTAAATTTCTCCGGTTGAAACCGAAACACGGCCTAGTTTCATGCTGATTTTATGGTAGAATCTGCGCCCTTTATGGCT
CGGGAGTGGATTTTTTATCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLACRGIWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPILQGIILNTRPAKVAKL
YQSVWTEQGSPLMVISEQQAQKLATDLSATFNQTIPVELGMSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASV
FDAVAQYFTQVRDIPELRFSKQYFDHEAYIAALAHSVKRHWKTHGQADKLILSFHGIPLRYATEGDPYPEQCRATAKLLA
QALELTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEEISIGGKETFLHAGGEAYHFI
PCLNDDELHIELLRQLVQEQAQPWIRAE

Sequences:

>Translated_348_residues
MLACRGIWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPILQGIILNTRPAKVAKL
YQSVWTEQGSPLMVISEQQAQKLATDLSATFNQTIPVELGMSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASV
FDAVAQYFTQVRDIPELRFSKQYFDHEAYIAALAHSVKRHWKTHGQADKLILSFHGIPLRYATEGDPYPEQCRATAKLLA
QALELTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEEISIGGKETFLHAGGEAYHFI
PCLNDDELHIELLRQLVQEQAQPWIRAE
>Mature_348_residues
MLACRGIWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPILQGIILNTRPAKVAKL
YQSVWTEQGSPLMVISEQQAQKLATDLSATFNQTIPVELGMSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASV
FDAVAQYFTQVRDIPELRFSKQYFDHEAYIAALAHSVKRHWKTHGQADKLILSFHGIPLRYATEGDPYPEQCRATAKLLA
QALELTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEEISIGGKETFLHAGGEAYHFI
PCLNDDELHIELLRQLVQEQAQPWIRAE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=336, Percent_Identity=26.4880952380952, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=26.4880952380952, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=54.6031746031746, Blast_Score=336, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=25.5255255255255, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=25.1461988304094, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24651774, Length=273, Percent_Identity=24.5421245421245, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38971; Mature: 38971

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLACRGIWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWL
CCEECEEEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHH
WQPILQGIILNTRPAKVAKLYQSVWTEQGSPLMVISEQQAQKLATDLSATFNQTIPVELG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEC
MSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASVFDAVAQYFTQVRDIPELRFS
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
KQYFDHEAYIAALAHSVKRHWKTHGQADKLILSFHGIPLRYATEGDPYPEQCRATAKLLA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCEEEECCCCCCCHHHHHHHHHHHH
QALELTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEE
HHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ISIGGKETFLHAGGEAYHFIPCLNDDELHIELLRQLVQEQAQPWIRAE
HCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLACRGIWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWL
CCEECEEEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHH
WQPILQGIILNTRPAKVAKLYQSVWTEQGSPLMVISEQQAQKLATDLSATFNQTIPVELG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEC
MSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASVFDAVAQYFTQVRDIPELRFS
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
KQYFDHEAYIAALAHSVKRHWKTHGQADKLILSFHGIPLRYATEGDPYPEQCRATAKLLA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCEEEECCCCCCCHHHHHHHHHHHH
QALELTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEE
HHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ISIGGKETFLHAGGEAYHFIPCLNDDELHIELLRQLVQEQAQPWIRAE
HCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]