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The map label for this gene is hemB [H]

Identifier: 117920835

GI number: 117920835

Start: 2870854

End: 2871852

Strand: Direct

Name: hemB [H]

Synonym: Shewana3_2392

Alternate gene names: 117920835

Gene position: 2870854-2871852 (Clockwise)

Preceding gene: 117920827

Following gene: 117920837

Centisome position: 57.74

GC content: 53.45

Gene sequence:

>999_bases
ATGAGCAGTACCAGAGAAAATACCCTTAAACCCCTTCGCCGTTTAAGACGCCTACGCCGCACTGAAGCCATGCGTGACCT
AGTGCGTGAAACCCAGATTTCCCTAAGCGACTTAGTCCACCCACTCTTTATTGAAGAGCACATCACCCAAGCCGTGCCCA
TTTCAACCTTGCCGGGGATCAGCCGTCTGCCCGAGAGTGCGCTTGCCGATGAAATTCAAAGGCTTTACGTATTAGGGATC
CGCTATGTGATGCCCTTTGGCATTTCCCACACCAAAGATGCACAGGGCAGCGACACTTGGGATGACAATGGCTTACTCGC
ACGGATGATCCGCACCATCAAAACCGCTGCGCCAGAGATGATGGTGATCCCCGATATTTGTTTTTGTGAATATACCGACC
ACGGACACTGCGGCGTATTGCACCATGACGAAGTCTGTAACGATCAAACCGTGGCTAACTTAGTTAAACAATCCATCACC
GCAGCCAAAGCGGGAGCCGATATGCTGGCGCCATCGGCGATGATGGACGGCCAGATTAACGCCATTCGTCAAGGGCTGGA
CGAGGCAGGCTTTGAGCACATCGCCATTTTGGCCCATGCAGCCAAGTTCGCCTCTTCCTTCTACGGGCCTTTTAGGGCCG
CGGTGGATTGCGAACTTAGCGGAAACCGTAAGGGCTACCAGCTCGATTACGCTAATGGTCGCCAAGCCTTGCTCGAAGCG
CTGCTCGATGAAGAGGAAGGCGCGGATATTCTGATGGTTAAACCCGGCACGCCCTATTTGGATGTGTTAAGTCGCCTAAG
ACAGGAAACCCACCTTCCCTTAGCGGCTTATCAAGTCGGCGGCGAATATGCCGGCATTAAGTTTGCCGCACTGGCGGGCG
CCCTCGATGAACGCGCCGTCGTCACCGAGACCTTTATCGGGTTAAAACGTGCTGGCGCCGATTTAATTGTCAGTTATTAC
GCAAAACAGTATGCCGAATGGTTAGCGCAATCCCGCTAA

Upstream 100 bases:

>100_bases
CACCAAAGCAACAACAAGTACAACCTAAGCATCGTTTTTACAATCTCCCTTTGACGCTAAGCTTCGCGTGATGCTTTCAC
ACTGTTAATAAGGAAATTCA

Downstream 100 bases:

>100_bases
TACACTGAGTCTTCAGCCTATCAGGCAAGCAATTAACGAAAACGCCACCCTAATTGGTGGCGTTTTTTATCCGTCATTTT
GCTCGCACATTAAGCCTATG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSSTRENTLKPLRRLRRLRRTEAMRDLVRETQISLSDLVHPLFIEEHITQAVPISTLPGISRLPESALADEIQRLYVLGI
RYVMPFGISHTKDAQGSDTWDDNGLLARMIRTIKTAAPEMMVIPDICFCEYTDHGHCGVLHHDEVCNDQTVANLVKQSIT
AAKAGADMLAPSAMMDGQINAIRQGLDEAGFEHIAILAHAAKFASSFYGPFRAAVDCELSGNRKGYQLDYANGRQALLEA
LLDEEEGADILMVKPGTPYLDVLSRLRQETHLPLAAYQVGGEYAGIKFAALAGALDERAVVTETFIGLKRAGADLIVSYY
AKQYAEWLAQSR

Sequences:

>Translated_332_residues
MSSTRENTLKPLRRLRRLRRTEAMRDLVRETQISLSDLVHPLFIEEHITQAVPISTLPGISRLPESALADEIQRLYVLGI
RYVMPFGISHTKDAQGSDTWDDNGLLARMIRTIKTAAPEMMVIPDICFCEYTDHGHCGVLHHDEVCNDQTVANLVKQSIT
AAKAGADMLAPSAMMDGQINAIRQGLDEAGFEHIAILAHAAKFASSFYGPFRAAVDCELSGNRKGYQLDYANGRQALLEA
LLDEEEGADILMVKPGTPYLDVLSRLRQETHLPLAAYQVGGEYAGIKFAALAGALDERAVVTETFIGLKRAGADLIVSYY
AKQYAEWLAQSR
>Mature_331_residues
SSTRENTLKPLRRLRRLRRTEAMRDLVRETQISLSDLVHPLFIEEHITQAVPISTLPGISRLPESALADEIQRLYVLGIR
YVMPFGISHTKDAQGSDTWDDNGLLARMIRTIKTAAPEMMVIPDICFCEYTDHGHCGVLHHDEVCNDQTVANLVKQSITA
AKAGADMLAPSAMMDGQINAIRQGLDEAGFEHIAILAHAAKFASSFYGPFRAAVDCELSGNRKGYQLDYANGRQALLEAL
LDEEEGADILMVKPGTPYLDVLSRLRQETHLPLAAYQVGGEYAGIKFAALAGALDERAVVTETFIGLKRAGADLIVSYYA
KQYAEWLAQSR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=37.5816993464052, Blast_Score=211, Evalue=9e-55,
Organism=Escherichia coli, GI87081728, Length=315, Percent_Identity=56.8253968253968, Blast_Score=357, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=40.3174603174603, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21358291, Length=294, Percent_Identity=37.4149659863946, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36661; Mature: 36530

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTRENTLKPLRRLRRLRRTEAMRDLVRETQISLSDLVHPLFIEEHITQAVPISTLPGI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SRLPESALADEIQRLYVLGIRYVMPFGISHTKDAQGSDTWDDNGLLARMIRTIKTAAPEM
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
MVIPDICFCEYTDHGHCGVLHHDEVCNDQTVANLVKQSITAAKAGADMLAPSAMMDGQIN
EECCCEEEEECCCCCCCCCEECHHHCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHH
AIRQGLDEAGFEHIAILAHAAKFASSFYGPFRAAVDCELSGNRKGYQLDYANGRQALLEA
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCEEEECCCCHHHHHHH
LLDEEEGADILMVKPGTPYLDVLSRLRQETHLPLAAYQVGGEYAGIKFAALAGALDERAV
HHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCHHH
VTETFIGLKRAGADLIVSYYAKQYAEWLAQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTRENTLKPLRRLRRLRRTEAMRDLVRETQISLSDLVHPLFIEEHITQAVPISTLPGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SRLPESALADEIQRLYVLGIRYVMPFGISHTKDAQGSDTWDDNGLLARMIRTIKTAAPEM
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
MVIPDICFCEYTDHGHCGVLHHDEVCNDQTVANLVKQSITAAKAGADMLAPSAMMDGQIN
EECCCEEEEECCCCCCCCCEECHHHCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHH
AIRQGLDEAGFEHIAILAHAAKFASSFYGPFRAAVDCELSGNRKGYQLDYANGRQALLEA
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCEEEECCCCHHHHHHH
LLDEEEGADILMVKPGTPYLDVLSRLRQETHLPLAAYQVGGEYAGIKFAALAGALDERAV
HHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCHHH
VTETFIGLKRAGADLIVSYYAKQYAEWLAQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2656410; 2464127; 9278503; 8439296; 10194344; 11444968; 11909869 [H]