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The map label for this gene is csrD [H]

Identifier: 117920611

GI number: 117920611

Start: 2598640

End: 2600544

Strand: Direct

Name: csrD [H]

Synonym: Shewana3_2167

Alternate gene names: 117920611

Gene position: 2598640-2600544 (Clockwise)

Preceding gene: 117920609

Following gene: 117920612

Centisome position: 52.26

GC content: 46.04

Gene sequence:

>1905_bases
ATGGCGATGTCTAAATCATATCCCATCTTTTTATTGCTGATTTTTTTAGGGCTGTTTGGTTGGATTTATCACAACGAAAA
TAATCAGCTCCAAGTGCAGCAACAGCAAGAGCTCAATAACTTTAAACAGTACATGGCTAACTTTGCCCAATGGCAAGGCA
ATGGCGCCGAGCTTTACCAAAGTATTGCCAGTCATTATCCGCTGCAATTTTTCCAATATGTCGATGATACCGACGGACAA
CTTAATTTTACTCAGGGCGATCTCAACTCCCAGAGCCCTCACCCGCTAGCCGGATTGTTTGCCTTAGATTTATCCCATAC
GCAAAAACTGGCTGCGGGGCGTTTACAGGTTAAGTTGAGTGCCGATCAAGCGATTGAAAATGCCATCACCAGTACCCAGC
AGTTGGGGATGGTATTGGTGCTGACCTATATCCTGTTGATGGTTGTTTTTATTTTGCTTATCAACAGATTAAAATCAGCT
ATCCGTTATGCGGCAGAGTATATCTCCCACATTCCTGACATGAATTTTTCCGCCATTGAATCTTCGAAGCTGAACGGTGA
AATGGCGCCAGTGAAATTAGCCTTAGAAGACTGCCGAACTCAGCTCAAATCAAAACTGGATTTGCTCACCCAAGAAAATC
AAAAATTACATAAAGCCGCCTATCAAGACCCTGTGACGGGTTTTGGCAGTCGTCCACCTTTTACCACTAAATTAGAAAGC
ATCAGTAACCGCAGCATCCCACAACTCGGGCTGTTAGCCATGGTCAAAGCGACTGAGCTTTCCCATGTGAACCAATTGCA
AGGCCGCTCAGCGGGTGATGATTATCTTGCGAGTGTAGCTAATTGCATTCGTAAGGCTTGTTCAAAATATCCCGATTCGG
AGTGTTACCGTGTCTCCAGTGCCGATTTTGCGATTTTTTTACCTGATTTAGTGTTAAAAGACGGCCCTAAGTTTTTAGAA
CAACTTAAAGTGTTCCTCGATGAATACCAACAAATGACCAGAGCCGAATCGGTGGCGCACATTGGCTTAGTGCCTTATCA
ACAGGGGACCGACCCCGTTAATTTGCTCTCCTTAGCAGACACCGCCGTCAGCATAGCGCAAACCTTAGGTCCTAATAGTT
TCCATATTCAAGAAAAGCTCAACGGCGACGAGCAGTTTGGGGATGACCGTTGGAAAGTGGCAATCAACGACTTAATCACC
CGCCAAGCGTTGAAGTTTTTCCAACAGCCGATTCAACCTTGCCGCAATGATGTCGAGGTCTATCGCGAGTTACTCGCACG
TTTTTACAACAACGAAGGCAAGTTTTTGCCTACCACCACCGTCATCGCCATGGCCGAGCGCCACGGCATGAGCACCGAAT
TAGATAAATTAGTGGTGATCAGCACATTAAGAATGCTTAAAGAAAATCCGACCATTAGCGGCAACTTTGGCGTCAATATC
AGCGCCTTTTCGGCCCATCAAGAACTGTTTGTCGGCTGGTTAAGGGATGTGTTGAGTAAACATAAATACATCGCTTCTCG
CCTAGTGTTTGAGATCAACGAATCCGGCATGCAGGCCAATTTAGGCGCCAGCTATAAGTTTGTCCGTGAAGTACACAGTG
TCGGTTCACGGGTCTCAATTGAGCGCTTTGGGATGAGCTTTACCTCCTTCAAATTCTTCAGTGAAGTGCGTCCAGACTAC
ATTAAGCTCGATGGCAGCTACACCTCATCAATCGATGAAGACAGCAATAATAAGTTCTTCGTGCGGATGATGGTCGATGT
GGCACGACGCATCGGCATTCGAGTTATCGCCACCAGTGTCGAGCGCCAAGAGGAAAAACTGACCCTCGAAAAACTCCTCG
TCGATGGTTTGCAGGGCTATTATATTGCCCAGCCACAGGCCATTACCTTAACTGACCAAATTTAA

Upstream 100 bases:

>100_bases
AACCAAAATTCCGAGTATCATCACGCAGATAGGGATATTGACTGAGCACTCTCTTAATATTCTGTCCGCAAATACTTCAC
CACATTGAGAGCGGATTTTT

Downstream 100 bases:

>100_bases
GCCAGCGCAGGGTTAATGGAGCGCGCAAATTTACAGTAAAGATAGTTAACCCTGCATTCTATATGTTGTTTATGCAAACG
GAAAAGTCGATAATACGGCC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MAMSKSYPIFLLLIFLGLFGWIYHNENNQLQVQQQQELNNFKQYMANFAQWQGNGAELYQSIASHYPLQFFQYVDDTDGQ
LNFTQGDLNSQSPHPLAGLFALDLSHTQKLAAGRLQVKLSADQAIENAITSTQQLGMVLVLTYILLMVVFILLINRLKSA
IRYAAEYISHIPDMNFSAIESSKLNGEMAPVKLALEDCRTQLKSKLDLLTQENQKLHKAAYQDPVTGFGSRPPFTTKLES
ISNRSIPQLGLLAMVKATELSHVNQLQGRSAGDDYLASVANCIRKACSKYPDSECYRVSSADFAIFLPDLVLKDGPKFLE
QLKVFLDEYQQMTRAESVAHIGLVPYQQGTDPVNLLSLADTAVSIAQTLGPNSFHIQEKLNGDEQFGDDRWKVAINDLIT
RQALKFFQQPIQPCRNDVEVYRELLARFYNNEGKFLPTTTVIAMAERHGMSTELDKLVVISTLRMLKENPTISGNFGVNI
SAFSAHQELFVGWLRDVLSKHKYIASRLVFEINESGMQANLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDY
IKLDGSYTSSIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITLTDQI

Sequences:

>Translated_634_residues
MAMSKSYPIFLLLIFLGLFGWIYHNENNQLQVQQQQELNNFKQYMANFAQWQGNGAELYQSIASHYPLQFFQYVDDTDGQ
LNFTQGDLNSQSPHPLAGLFALDLSHTQKLAAGRLQVKLSADQAIENAITSTQQLGMVLVLTYILLMVVFILLINRLKSA
IRYAAEYISHIPDMNFSAIESSKLNGEMAPVKLALEDCRTQLKSKLDLLTQENQKLHKAAYQDPVTGFGSRPPFTTKLES
ISNRSIPQLGLLAMVKATELSHVNQLQGRSAGDDYLASVANCIRKACSKYPDSECYRVSSADFAIFLPDLVLKDGPKFLE
QLKVFLDEYQQMTRAESVAHIGLVPYQQGTDPVNLLSLADTAVSIAQTLGPNSFHIQEKLNGDEQFGDDRWKVAINDLIT
RQALKFFQQPIQPCRNDVEVYRELLARFYNNEGKFLPTTTVIAMAERHGMSTELDKLVVISTLRMLKENPTISGNFGVNI
SAFSAHQELFVGWLRDVLSKHKYIASRLVFEINESGMQANLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDY
IKLDGSYTSSIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITLTDQI
>Mature_633_residues
AMSKSYPIFLLLIFLGLFGWIYHNENNQLQVQQQQELNNFKQYMANFAQWQGNGAELYQSIASHYPLQFFQYVDDTDGQL
NFTQGDLNSQSPHPLAGLFALDLSHTQKLAAGRLQVKLSADQAIENAITSTQQLGMVLVLTYILLMVVFILLINRLKSAI
RYAAEYISHIPDMNFSAIESSKLNGEMAPVKLALEDCRTQLKSKLDLLTQENQKLHKAAYQDPVTGFGSRPPFTTKLESI
SNRSIPQLGLLAMVKATELSHVNQLQGRSAGDDYLASVANCIRKACSKYPDSECYRVSSADFAIFLPDLVLKDGPKFLEQ
LKVFLDEYQQMTRAESVAHIGLVPYQQGTDPVNLLSLADTAVSIAQTLGPNSFHIQEKLNGDEQFGDDRWKVAINDLITR
QALKFFQQPIQPCRNDVEVYRELLARFYNNEGKFLPTTTVIAMAERHGMSTELDKLVVISTLRMLKENPTISGNFGVNIS
AFSAHQELFVGWLRDVLSKHKYIASRLVFEINESGMQANLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDYI
KLDGSYTSSIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITLTDQI

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=439, Percent_Identity=23.6902050113895, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI87081980, Length=237, Percent_Identity=29.1139240506329, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788849, Length=244, Percent_Identity=29.0983606557377, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI87082096, Length=225, Percent_Identity=28.4444444444444, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1787541, Length=288, Percent_Identity=25.6944444444444, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787055, Length=230, Percent_Identity=25.6521739130435, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788502, Length=207, Percent_Identity=25.1207729468599, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081845, Length=251, Percent_Identity=23.9043824701195, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1790496, Length=228, Percent_Identity=19.7368421052632, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081921, Length=414, Percent_Identity=20.5314009661836, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786507, Length=244, Percent_Identity=24.5901639344262, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87081743, Length=219, Percent_Identity=21.4611872146119, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71502; Mature: 71370

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMSKSYPIFLLLIFLGLFGWIYHNENNQLQVQQQQELNNFKQYMANFAQWQGNGAELYQ
CCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SIASHYPLQFFQYVDDTDGQLNFTQGDLNSQSPHPLAGLFALDLSHTQKLAAGRLQVKLS
HHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
ADQAIENAITSTQQLGMVLVLTYILLMVVFILLINRLKSAIRYAAEYISHIPDMNFSAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SSKLNGEMAPVKLALEDCRTQLKSKLDLLTQENQKLHKAAYQDPVTGFGSRPPFTTKLES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
ISNRSIPQLGLLAMVKATELSHVNQLQGRSAGDDYLASVANCIRKACSKYPDSECYRVSS
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEEECC
ADFAIFLPDLVLKDGPKFLEQLKVFLDEYQQMTRAESVAHIGLVPYQQGTDPVNLLSLAD
CCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TAVSIAQTLGPNSFHIQEKLNGDEQFGDDRWKVAINDLITRQALKFFQQPIQPCRNDVEV
HHHHHHHHCCCCCEEEHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNNEGKFLPTTTVIAMAERHGMSTELDKLVVISTLRMLKENPTISGNFGVNI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
SAFSAHQELFVGWLRDVLSKHKYIASRLVFEINESGMQANLGASYKFVREVHSVGSRVSI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEH
ERFGMSFTSFKFFSEVRPDYIKLDGSYTSSIDEDSNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCHHHEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAITLTDQI
HHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCC
>Mature Secondary Structure 
AMSKSYPIFLLLIFLGLFGWIYHNENNQLQVQQQQELNNFKQYMANFAQWQGNGAELYQ
CCCCCCHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SIASHYPLQFFQYVDDTDGQLNFTQGDLNSQSPHPLAGLFALDLSHTQKLAAGRLQVKLS
HHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
ADQAIENAITSTQQLGMVLVLTYILLMVVFILLINRLKSAIRYAAEYISHIPDMNFSAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SSKLNGEMAPVKLALEDCRTQLKSKLDLLTQENQKLHKAAYQDPVTGFGSRPPFTTKLES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
ISNRSIPQLGLLAMVKATELSHVNQLQGRSAGDDYLASVANCIRKACSKYPDSECYRVSS
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEEECC
ADFAIFLPDLVLKDGPKFLEQLKVFLDEYQQMTRAESVAHIGLVPYQQGTDPVNLLSLAD
CCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TAVSIAQTLGPNSFHIQEKLNGDEQFGDDRWKVAINDLITRQALKFFQQPIQPCRNDVEV
HHHHHHHHCCCCCEEEHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNNEGKFLPTTTVIAMAERHGMSTELDKLVVISTLRMLKENPTISGNFGVNI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
SAFSAHQELFVGWLRDVLSKHKYIASRLVFEINESGMQANLGASYKFVREVHSVGSRVSI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEH
ERFGMSFTSFKFFSEVRPDYIKLDGSYTSSIDEDSNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCHHHEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAITLTDQI
HHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]