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The map label for this gene is hisB [H]

Identifier: 117920296

GI number: 117920296

Start: 2192374

End: 2193465

Strand: Reverse

Name: hisB [H]

Synonym: Shewana3_1851

Alternate gene names: 117920296

Gene position: 2193465-2192374 (Counterclockwise)

Preceding gene: 117920297

Following gene: 117920295

Centisome position: 44.11

GC content: 51.74

Gene sequence:

>1092_bases
ATGAACCCAGTATTTACCCCTAATGTCGCCCAGAAAATACTCTTTATCGACCGCGATGGCACCTTGATTGAAGAGCCCAT
CACCGACAAACAAGTCGATAGCCTCGCCAAACTGGTATTCGAGCCCCAAGTGATCCCAGCCTTACTGCGCCTGCAAAAAG
CCGGGTTTAGGTTGGTGATGGTTAGCAATCAGGACGGACTCGGTACCCCTTCCTTCCCGCAGGAAGATTTCGATGCGCCG
CACAATATGATGATGCAAATCCTCTCCAGCCAAGGGGTTAAGTTTGAAGATGTACTGATCTGCCCGCACTTTAACGATGA
AAACTGCAGCTGCCGTAAACCTAAACTTGGGCTGGTGAAAGACTTTTTGACCCAAGGCACCATCGATTTTACCCAGTCCG
CCGTGATTGGTGACAGACACACAGATGTAGAACTGGGCAATGCCATGGGGATAAAAAGCTTTCAATATCAGCGTGGCAGC
CTAGGCTGGGACGCAATTGCCGATGCCTTACTCAACAAGGGCCGCACCGCAACAGTTGTACGTACCACCAAGGAAACCGA
TATTCGCGTAACTGTCGATCTCGACAATCCCAGCAAAGGCGCCATCAACACCGGCATTGGTTTCTTCGACCATATGCTGG
ATCAAATCGCCACCCACGGAAACTTCAAAATGGAGGTGAATGTCGATGGCGATCTTGAAATAGACGATCACCACAGCGTT
GAAGACACGGCATTAGCGATTGGGGATGCACTGCGCCAAGCACTGGGCGATAAACGCGGTATTGCCCGTTTTGGTTTTAG
TTTGCCGATGGATGAGGCCAAGGGCGAATGCTTACTCGATCTCTCCGGCAGGCCTTTTATTAAATTCGCCGCCCAATTTG
AACGGGAAAAAGTCGGTGAAATGGCCACCGAAATGGTGCCGCACTTTTTCCGCTCCTTTGCCGATGGCCTACGCTGCACC
CTACATGTGGCCGCCGAGGGAGACAACGATCACCACAAGGTCGAGGCGCTATTTAAAGTACTGGGCCGCGCGCTACGTCA
GGCCGTCAAAGTTGAAGGCGATGTCTTGCCATCGAGTAAAGGCGTGCTCTAA

Upstream 100 bases:

>100_bases
GAATCGCAAAAGCTATGAGCATTTAGCGCAAGTCTTGTCGCAGCATTGGCCTAATAAACTGATTTTATAAAGATAACAAA
CTGAATTGAAAGGTAGCAGC

Downstream 100 bases:

>100_bases
CACCTCACTCAATCTGAGTTAGGTGCTTAATGACCTGATGCAGATTGATTAGCGAATAATACAAAGCCTGATGATTTTAA
CGAGGGCAGTTCCGGAATGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNPVFTPNVAQKILFIDRDGTLIEEPITDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVKDFLTQGTIDFTQSAVIGDRHTDVELGNAMGIKSFQYQRGS
LGWDAIADALLNKGRTATVVRTTKETDIRVTVDLDNPSKGAINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGEMATEMVPHFFRSFADGLRCT
LHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSKGVL

Sequences:

>Translated_363_residues
MNPVFTPNVAQKILFIDRDGTLIEEPITDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVKDFLTQGTIDFTQSAVIGDRHTDVELGNAMGIKSFQYQRGS
LGWDAIADALLNKGRTATVVRTTKETDIRVTVDLDNPSKGAINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGEMATEMVPHFFRSFADGLRCT
LHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSKGVL
>Mature_363_residues
MNPVFTPNVAQKILFIDRDGTLIEEPITDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVKDFLTQGTIDFTQSAVIGDRHTDVELGNAMGIKSFQYQRGS
LGWDAIADALLNKGRTATVVRTTKETDIRVTVDLDNPSKGAINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGEMATEMVPHFFRSFADGLRCT
LHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=61.1267605633803, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786399, Length=148, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=41.2037037037037, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39996; Mature: 39996

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVFTPNVAQKILFIDRDGTLIEEPITDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVM
CCCCCCCCHHCEEEEECCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEE
VSNQDGLGTPSFPQEDFDAPHNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVK
EECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
DFLTQGTIDFTQSAVIGDRHTDVELGNAMGIKSFQYQRGSLGWDAIADALLNKGRTATVV
HHHHCCCCHHHHHHHCCCCCCCEECCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEE
RTTKETDIRVTVDLDNPSKGAINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EECCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCC
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGE
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
MATEMVPHFFRSFADGLRCTLHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSK
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVL
CCC
>Mature Secondary Structure
MNPVFTPNVAQKILFIDRDGTLIEEPITDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVM
CCCCCCCCHHCEEEEECCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEE
VSNQDGLGTPSFPQEDFDAPHNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVK
EECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
DFLTQGTIDFTQSAVIGDRHTDVELGNAMGIKSFQYQRGSLGWDAIADALLNKGRTATVV
HHHHCCCCHHHHHHHCCCCCCCEECCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEE
RTTKETDIRVTVDLDNPSKGAINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EECCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCC
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGE
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
MATEMVPHFFRSFADGLRCTLHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSK
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]