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The map label for this gene is hisA [H]

Identifier: 117920294

GI number: 117920294

Start: 2190811

End: 2191548

Strand: Reverse

Name: hisA [H]

Synonym: Shewana3_1849

Alternate gene names: 117920294

Gene position: 2191548-2190811 (Counterclockwise)

Preceding gene: 117920295

Following gene: 117920293

Centisome position: 44.08

GC content: 52.03

Gene sequence:

>738_bases
ATGATCATTCCAGCAATTGATTTAATTGATGGCCAGATAGTTAGGCTCTACCAAGGGGATTATGGGCAGCAGACCACTTT
CGATTTAAGCCCGCAGACCCAGTTGCAATCCTACCAAGACCAAGGGGCAAGCTGGCTGCATATAGTAGATTTAACTGGCG
CCAAAGAACCCGCTAAACGCCAAACGGCTTTGATTGCTAAGCTGACAGCGGGGCTTAACGCCAATATTCAAGTGGGCGGC
GGGATCCGCACTGAAGAGCAAGTCGCCGAGTTATTGTCCCTTGGGGTAAAACGCGTGGTAATAGGCTCGCTCGCCGTCAA
AGAGCCCGAGTTAGTCAAAGGCTGGTTTAACAAGTTTGGCAGCGAGGCAATTTGCCTGGCACTGGATGTGAATATCAATC
AGAACGGCGAGAAAATCGTCGCGGTTTCTGGCTGGCAAAGCGGTGGCGGTAAGAGTCTAGAATCTATCGTCGAGGACTTT
AGCCAAGTGGGACTTAAACATGCGCTGGTGACTGACATCAATCGCGATGGCACCCTCACTGGCGCCAATACCGCACTCTA
CCGTGAGCTATCCAGCCACTATCCCCATATCGCTTGGCAAGCCTCGGGCGGCATTGCCACCCTTGAGGATGTTGCCGCCG
TCAGAGACAGTGGCGCCGCGGGGATCATTATCGGTAAAGCTTTACTTATCAATCAGTTTAATGTGGCGGAGGCAATCCAA
TGCTGGCCAAACGAATAG

Upstream 100 bases:

>100_bases
TGCAATTTCACCCCGAAAAGAGCGCCGCCGTGGGTGCGCAAATCCTAGGTAACTTTTTAAAAATGCAGTAAATGCACCAA
AAAGAATTTAAGGACAACAG

Downstream 100 bases:

>100_bases
TCCCCTGTTTAGATGTGAAAGATGGCTGCGTGGTCAAGGGCGTACAGTTTCGCAACCATGAAATTGTTGGCGACATAGTA
CCTCTCGCGGCGCGTTACGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPAIDLIDGQIVRLYQGDYGQQTTFDLSPQTQLQSYQDQGASWLHIVDLTGAKEPAKRQTALIAKLTAGLNANIQVGG
GIRTEEQVAELLSLGVKRVVIGSLAVKEPELVKGWFNKFGSEAICLALDVNINQNGEKIVAVSGWQSGGGKSLESIVEDF
SQVGLKHALVTDINRDGTLTGANTALYRELSSHYPHIAWQASGGIATLEDVAAVRDSGAAGIIIGKALLINQFNVAEAIQ
CWPNE

Sequences:

>Translated_245_residues
MIIPAIDLIDGQIVRLYQGDYGQQTTFDLSPQTQLQSYQDQGASWLHIVDLTGAKEPAKRQTALIAKLTAGLNANIQVGG
GIRTEEQVAELLSLGVKRVVIGSLAVKEPELVKGWFNKFGSEAICLALDVNINQNGEKIVAVSGWQSGGGKSLESIVEDF
SQVGLKHALVTDINRDGTLTGANTALYRELSSHYPHIAWQASGGIATLEDVAAVRDSGAAGIIIGKALLINQFNVAEAIQ
CWPNE
>Mature_245_residues
MIIPAIDLIDGQIVRLYQGDYGQQTTFDLSPQTQLQSYQDQGASWLHIVDLTGAKEPAKRQTALIAKLTAGLNANIQVGG
GIRTEEQVAELLSLGVKRVVIGSLAVKEPELVKGWFNKFGSEAICLALDVNINQNGEKIVAVSGWQSGGGKSLESIVEDF
SQVGLKHALVTDINRDGTLTGANTALYRELSSHYPHIAWQASGGIATLEDVAAVRDSGAAGIIIGKALLINQFNVAEAIQ
CWPNE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=59.0163934426229, Blast_Score=301, Evalue=2e-83,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=23.7903225806452, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26177; Mature: 26177

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPAIDLIDGQIVRLYQGDYGQQTTFDLSPQTQLQSYQDQGASWLHIVDLTGAKEPAKR
CCCCCEECCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHH
QTALIAKLTAGLNANIQVGGGIRTEEQVAELLSLGVKRVVIGSLAVKEPELVKGWFNKFG
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCC
SEAICLALDVNINQNGEKIVAVSGWQSGGGKSLESIVEDFSQVGLKHALVTDINRDGTLT
CCEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCEE
GANTALYRELSSHYPHIAWQASGGIATLEDVAAVRDSGAAGIIIGKALLINQFNVAEAIQ
CCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHHHHH
CWPNE
CCCCC
>Mature Secondary Structure
MIIPAIDLIDGQIVRLYQGDYGQQTTFDLSPQTQLQSYQDQGASWLHIVDLTGAKEPAKR
CCCCCEECCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHH
QTALIAKLTAGLNANIQVGGGIRTEEQVAELLSLGVKRVVIGSLAVKEPELVKGWFNKFG
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCC
SEAICLALDVNINQNGEKIVAVSGWQSGGGKSLESIVEDFSQVGLKHALVTDINRDGTLT
CCEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCEE
GANTALYRELSSHYPHIAWQASGGIATLEDVAAVRDSGAAGIIIGKALLINQFNVAEAIQ
CCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHHHHH
CWPNE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]