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The map label for this gene is tmk [H]

Identifier: 117920213

GI number: 117920213

Start: 2080273

End: 2080902

Strand: Direct

Name: tmk [H]

Synonym: Shewana3_1766

Alternate gene names: 117920213

Gene position: 2080273-2080902 (Clockwise)

Preceding gene: 117920212

Following gene: 117920214

Centisome position: 41.84

GC content: 52.54

Gene sequence:

>630_bases
ATGACCCAAGCATCCGCCAAATTCATTGTTGTTGAAGGACTGGAAGGCGCAGGCAAATCGAGTGCGATTGCCCTTATTCG
CGATTTTATTGAAAAACATACCGGCCTTGCACCCGTGTGTACCCGCGAGCCAGGCGGTACGCCGCTGGCCGAGCGCATTC
GTGACTTAGTGAAAATTGCTGACCCAAGCGATCCTCTGTGTGATGAGTCCGAATGTTTATTGATCTACGCCGCTAGAGCC
CAGCTCGTCGCCAATGTGATCAAACCCGCGCTGGCAGAAGGCAAGTGGGTGTTAGGGGATAGACACAATCTTTCATCCTT
AGCTTACCAAGGCGGTGGACGCGGCTTAATGCCCTTAGTCGAAGCCGTGAGTAACGCGACACTTAAAGGCTTTAAACCTG
ATTTAACCCTCTATCTTGACCTTGATCCAAAGCTTGGGTTGCTGCGCGCAGCAAAGCGGGGCGAGCTTGATAGGATCGAG
CAACAAGCCATCGACTTTTTTGAACGGGCGCGCGCAACTTACCTCAAGCTTGCCAGCGAAGATGAGCGGATTGTTGTCAT
CGACGCCAGCCAAACCATGGCCGAAGTGCATAAAGATATTCTGGCCGTGTTACAGGCGATGGCATGGTAG

Upstream 100 bases:

>100_bases
GTTATTTATATTTTGTGTCGCGCAACGATGGCACCCATGTGTTTTCGACCACCTTGGAAGAACACAATCGCGCCGTCGAT
ATTTATCAGAGAAAGAAAAA

Downstream 100 bases:

>100_bases
CGCAAAGCGGATTTGATGTATTAACCCTGCCTTGGCTCGATACGCCAAGACAGGCGTTTTTAACCCAGTTACAAACCCAA
AAAGTCCCCCACGCGCAACT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIADPSDPLCDESECLLIYAARA
QLVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLVEAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIE
QQAIDFFERARATYLKLASEDERIVVIDASQTMAEVHKDILAVLQAMAW

Sequences:

>Translated_209_residues
MTQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIADPSDPLCDESECLLIYAARA
QLVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLVEAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIE
QQAIDFFERARATYLKLASEDERIVVIDASQTMAEVHKDILAVLQAMAW
>Mature_208_residues
TQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIADPSDPLCDESECLLIYAARAQ
LVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLVEAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIEQ
QAIDFFERARATYLKLASEDERIVVIDASQTMAEVHKDILAVLQAMAW

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=194, Percent_Identity=54.1237113402062, Blast_Score=203, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22709; Mature: 22577

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIA
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHC
DPSDPLCDESECLLIYAARAQLVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLV
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHH
EAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIEQQAIDFFERARATYLKLASE
HHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DERIVVIDASQTMAEVHKDILAVLQAMAW
CCEEEEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIA
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHC
DPSDPLCDESECLLIYAARAQLVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLV
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHH
EAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIEQQAIDFFERARATYLKLASE
HHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DERIVVIDASQTMAEVHKDILAVLQAMAW
CCEEEEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]