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The map label for this gene is sdhA [H]

Identifier: 117920155

GI number: 117920155

Start: 2009952

End: 2011718

Strand: Direct

Name: sdhA [H]

Synonym: Shewana3_1708

Alternate gene names: 117920155

Gene position: 2009952-2011718 (Clockwise)

Preceding gene: 117920154

Following gene: 117920156

Centisome position: 40.42

GC content: 49.07

Gene sequence:

>1767_bases
GTGAGTATTCCAGTACGTGAGTTTGATGCTGTAGTGATTGGTGCCGGCGGTGCTGGTATGCGCGCAGCATTACAGATTTC
TAAAGAAGGTAAGAGCTGTGCGCTTTTATCTAAAGTATTCCCAACCCGTTCTCATACTGTTTCTGCGCAGGGTGGTATCA
CCGTTGCGTTAGGTAACGCCCATGAAGACCATTGGGAACAACACATGTACGATACCGTAAAAGGTTCCGACTTTATCGGT
GACCAAGACGCTATCGAATTTATGTGTCAAACCGGTCCAGAAGCCATTATTGAACTCGAGCACATGGGTTTACCCTTCTC
TCGTTTCGATAACGGTAAGATTTACCAACGTCCTTTCGGTGGTCAATCTAAAAACTTCGGTGGTGAACAAGCGGCGCGTA
CCGCTGCAGCAGCAGACCGTACTGGTCACGCACTGCTTCACTGCTTATACCAACAGAACGTTAAACACAAAACCCAAGTG
TTTTCTGAGTGGTATGCCCTCGATTTAGTGAAAAACCAAGACGGTGCCATCGTAGGTTGTACTGCGATTGAAATCGAAAC
GGGTGAAATCGTTTACTTCAAAGCCAAAGCCACTGTACTCGCGACTGGCGGTGCTGGTCGTATCTACGCATCAACCACAA
ACGCACACATCAATACCGGTGACGGTGTTGGTATGGCAATGCGTGCTGGTGTTCAGATGCAAGATATGGAAATGTGGCAA
TTCCACCCAACCGGTATCGCTGGTGCGGGTGTACTTGTGACTGAAGGTTGTCGTGGTGAAGGCGGTTACCTGCTGAACAA
AGACGGCGAGCGTTTCATGGAGCGTTATGCTCCAAACGCCAAGGACTTAGCATCTCGTGACGTGGTAGCACGTTCTATGA
TGACTGAAATCCGTGAAGGCCGTGGTTTAGATGGTCCATTAGGCCCACACTGCTTGCTGAAACTCGACCACTTAGGTAAA
GAGACCTTAGAAGCCCGTCTACCAGGCGTGTGTGAACTTTCTCGTACCTTCGCGCATATCGATCCGGCCGATGGTCCAAT
CCCTGTTCTGCCAACCTGTCACTATATGATGGGTGGTCTGCCAACGAAGGTGAGCGGTCAAGTTATTCGTAAGAATGACG
ACGGCAGCGAGCAAGATGTGGTTGGTTTATTCGCAGTAGGTGAGATTGCCTGTGTGTCTGTACACGGTGCTAACCGCTTA
GGCGGTAACTCTCTGCTCGACTTAGTGGTCTTTGGCCGCGCTGCGGGTCAACACTTGGGTAAAGCACTCGATGAGACTGC
GGATCCAAAAGATGCGACCGATGCGGAAATTCAAGCGACTTTAGCACGCTTAAACCGCTGGGAAAGCAACAAGTCTGGCG
AAGACCCAGCGCAAATCCGTAAAGATTTACAACTTTGCATGCAATTAAACTTCTCTGTATTCCGCCGTGGCGATGCAATG
GCAGAAGGTTTAGAGCAGTTAAAAGCTATCCGTAAGCGTTTAGAAAATGCCAAGTTGTCTGATAATTCTCGCGAATTCAA
CACTCAACGTATTGAATGTTTAGAGTTAGACAACCTGATGGCGACGGCAATTGCCACCGCTTATGCTGCTAACTTCCGTA
CAGAGAGCCGTGGTGCTCACTCACGTGAAGACTATTTAGAGCGTGATGATGATAACTGGTTATGTCACACCCTGTTTGAC
CCTGTGACTGAAACCATGGACCGTCGTGCTGTGAATATGGCGCCTAAGTTACGTGAAGCATTCCCGCCGAAGAAACGTAC
CTACTAG

Upstream 100 bases:

>100_bases
CGTCAAGTGCACTTCGTTACGCGGTGTTTTACAGTTCACCTTCGTCGTCACCGTCTTTTGTTATCTGGCGGCCGGCATTG
TTATTGTGTGGGGTGTCTAA

Downstream 100 bases:

>100_bases
GAGTTGCAAAGATGAAATTGGAATTTGCAGTTTATCGTTACAATCCTGATGTAGATACAAAACCTTACATGCAGGATTAC
AGCCTCGAAGTGGCTGAAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQDAIEFMCQTGPEAIIELEHMGLPFSRFDNGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQV
FSEWYALDLVKNQDGAIVGCTAIEIETGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNDDGSEQDVVGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETADPKDATDAEIQATLARLNRWESNKSGEDPAQIRKDLQLCMQLNFSVFRRGDAM
AEGLEQLKAIRKRLENAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDDNWLCHTLFD
PVTETMDRRAVNMAPKLREAFPPKKRTY

Sequences:

>Translated_588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQDAIEFMCQTGPEAIIELEHMGLPFSRFDNGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQV
FSEWYALDLVKNQDGAIVGCTAIEIETGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNDDGSEQDVVGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETADPKDATDAEIQATLARLNRWESNKSGEDPAQIRKDLQLCMQLNFSVFRRGDAM
AEGLEQLKAIRKRLENAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDDNWLCHTLFD
PVTETMDRRAVNMAPKLREAFPPKKRTY
>Mature_587_residues
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIGD
QDAIEFMCQTGPEAIIELEHMGLPFSRFDNGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVF
SEWYALDLVKNQDGAIVGCTAIEIETGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGKE
TLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNDDGSEQDVVGLFAVGEIACVSVHGANRLG
GNSLLDLVVFGRAAGQHLGKALDETADPKDATDAEIQATLARLNRWESNKSGEDPAQIRKDLQLCMQLNFSVFRRGDAMA
EGLEQLKAIRKRLENAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDDNWLCHTLFDP
VTETMDRRAVNMAPKLREAFPPKKRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=550, Percent_Identity=53.4545454545455, Blast_Score=529, Evalue=1e-150,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=79.7619047619048, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=39.6160558464223, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1788928, Length=572, Percent_Identity=29.3706293706294, Blast_Score=207, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17505833, Length=593, Percent_Identity=48.397976391231, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17550100, Length=588, Percent_Identity=48.1292517006803, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71986328, Length=78, Percent_Identity=48.7179487179487, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=53.971119133574, Blast_Score=571, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=51.3513513513513, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=28.0163599182004, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=24.435318275154, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=53.0275229357798, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=53.0275229357798, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=53.0275229357798, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24663005, Length=615, Percent_Identity=45.5284552845528, Blast_Score=506, Evalue=1e-143,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64187; Mature: 64056

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQDAIEFMCQTGPEAIIELEHMGLPFSRFDNGKIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVFSEWYALDLVKNQDGAIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCEEEE
TAIEIETGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PTKVSGQVIRKNDDGSEQDVVGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEEECCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETADPKDATDAEIQATLARLNRWESNKSGEDPAQIRKDLQLCMQLNFSVFRRGDAM
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCHHH
AEGLEQLKAIRKRLENAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDDNWLCHTLFDPVTETMDRRAVNMAPKLREAFPPKKRTY
CHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQDAIEFMCQTGPEAIIELEHMGLPFSRFDNGKIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVFSEWYALDLVKNQDGAIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCEEEE
TAIEIETGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PTKVSGQVIRKNDDGSEQDVVGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEEECCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETADPKDATDAEIQATLARLNRWESNKSGEDPAQIRKDLQLCMQLNFSVFRRGDAM
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCHHH
AEGLEQLKAIRKRLENAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDDNWLCHTLFDPVTETMDRRAVNMAPKLREAFPPKKRTY
CHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]