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The map label for this gene is dapA [H]

Identifier: 117920103

GI number: 117920103

Start: 1946279

End: 1947163

Strand: Direct

Name: dapA [H]

Synonym: Shewana3_1656

Alternate gene names: 117920103

Gene position: 1946279-1947163 (Clockwise)

Preceding gene: 117920100

Following gene: 117920104

Centisome position: 39.14

GC content: 50.73

Gene sequence:

>885_bases
ATGATAAACGGAAGCATCGTAGCCTTAATCACGCCAATGAACAGTGATGGCTCAGTAGATTTTGCAAGTCTTGAAAGGTT
AGTCGAATTCCATATTGACCAAGGCACAGACGCCATCGTCGCCGTGGGCACTACCGGCGAGTCAGCGACTCTGCCAATGA
ATGAGCACGTTACTGTGGTCGCGCAAACGGTTAAGTTTGCCGCAGGCCGTATTCCTGTGATTGGTGGCAATGGCGCGAAT
GCGACATCTGAAGCTATCGAACTCACCAAGTCTTTATCTAAAGTAGGGGTTGCCGCCATGTTAGGCGTGACACCTTACTA
CAACAAGCCCACGCCAAAGGGCTTAGTCGCGCACTATAAAGCGGTCGCGGCGAGCACGGATATTCCGCAAATTCTCTATA
ACGTACCAGGACGCACCGCCGTCGACATGAAGCCCGAAACCGTGGCCGAATTGGTCGCTGTGAGCAATATTATTGGTGTT
AAAGAAGCCACGGGTGATGTATCACGCGTACAGCGTTTACGTGAGCTTTGCGGTAATGACTTTATGTTGTACAGCGGCGA
TGACGCAACGGCGAGGGAGTTTTTACTCCTTGGCGGTAATGGCGTGATTTCGGTTGCTAACAACATAGTGCCAAAAGCAT
TTAAAGCCATGTGTGATGCAGCACTGGCGGGCAACGCCGAATTAGCGGCGAGCATCGATGAGCCGCTGCGTGGTCTGTAT
AGCACACTGTTCTGTGAAGCGAACCCAATTCCTGTGAAGTGGGCCGCCCACCGTATGGGACTGATTGAGTGTGGCCATAT
TCGTTTACCTTTGACTGAACTTTCTGAGCAATGTCATGGTCTGTTGTTAGATGCAATGACTCGCGCCCAGATAGAGGTTA
AATAA

Upstream 100 bases:

>100_bases
AATGCTACCATAACTAATTCAATTTGAGAGCCCCGTTAGTGCTTGTCATTAATGGTTGGCATCAGTACCATAGCGAATCC
TGAAATTTTGGGGAAGTCAG

Downstream 100 bases:

>100_bases
TTAATGTTAAAGAAAGTCACCCCACTGTTCCTAGTTGCTGCCGTTGCAGCTTGTAGCTCGCCATTAGAGCGTCGCCAAGC
AAACGGCGGTGAAGACTATG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMNEHVTVVAQTVKFAAGRIPVIGGNGAN
ATSEAIELTKSLSKVGVAAMLGVTPYYNKPTPKGLVAHYKAVAASTDIPQILYNVPGRTAVDMKPETVAELVAVSNIIGV
KEATGDVSRVQRLRELCGNDFMLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELAASIDEPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLLDAMTRAQIEVK

Sequences:

>Translated_294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMNEHVTVVAQTVKFAAGRIPVIGGNGAN
ATSEAIELTKSLSKVGVAAMLGVTPYYNKPTPKGLVAHYKAVAASTDIPQILYNVPGRTAVDMKPETVAELVAVSNIIGV
KEATGDVSRVQRLRELCGNDFMLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELAASIDEPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLLDAMTRAQIEVK
>Mature_294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMNEHVTVVAQTVKFAAGRIPVIGGNGAN
ATSEAIELTKSLSKVGVAAMLGVTPYYNKPTPKGLVAHYKAVAASTDIPQILYNVPGRTAVDMKPETVAELVAVSNIIGV
KEATGDVSRVQRLRELCGNDFMLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELAASIDEPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLLDAMTRAQIEVK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=213, Percent_Identity=29.5774647887324, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13540533, Length=243, Percent_Identity=25.1028806584362, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788823, Length=276, Percent_Identity=52.536231884058, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI87082415, Length=281, Percent_Identity=27.4021352313167, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789620, Length=277, Percent_Identity=27.4368231046931, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786463, Length=248, Percent_Identity=28.2258064516129, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31000; Mature: 31000

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMNEHVTVV
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHH
AQTVKFAAGRIPVIGGNGANATSEAIELTKSLSKVGVAAMLGVTPYYNKPTPKGLVAHYK
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVAASTDIPQILYNVPGRTAVDMKPETVAELVAVSNIIGVKEATGDVSRVQRLRELCGND
HHHCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCC
FMLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELAASIDEPLRGLY
EEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLLDAMTRAQIEVK
HHHHCCCCCCCEEHHHHHCCEEEECCEECCHHHHHHHHHHHHHHHHHHCEEEEC
>Mature Secondary Structure
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMNEHVTVV
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHH
AQTVKFAAGRIPVIGGNGANATSEAIELTKSLSKVGVAAMLGVTPYYNKPTPKGLVAHYK
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVAASTDIPQILYNVPGRTAVDMKPETVAELVAVSNIIGVKEATGDVSRVQRLRELCGND
HHHCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCC
FMLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELAASIDEPLRGLY
EEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLLDAMTRAQIEVK
HHHHCCCCCCCEEHHHHHCCEEEECCEECCHHHHHHHHHHHHHHHHHHCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA