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The map label for this gene is lysC [H]

Identifier: 117919578

GI number: 117919578

Start: 1330865

End: 1332121

Strand: Direct

Name: lysC [H]

Synonym: Shewana3_1129

Alternate gene names: 117919578

Gene position: 1330865-1332121 (Clockwise)

Preceding gene: 117919577

Following gene: 117919579

Centisome position: 26.77

GC content: 47.73

Gene sequence:

>1257_bases
GTGCTCGAAAAACGAAAGCTTAGTGGTAGCAAGCTTTTTGTGAAGAAGTTTGGTGGCACTTCGGTGGGTTCGATTGAACG
CATCGAAGTGGTTGCCGAGCAAATTGCAAAGTCCGCTCACAATGGTGAGCTGCAAGTCTTGGTGCTTTCTGCGATGGCAG
GGGAGACCAACAGACTATTTGCGCTTGCGGCGCAAATCGATCCCCGCGCGAGTGCGCGGGAACTCGATATGCTGGTCTCG
ACGGGAGAGCAAATCAGTATTGCGTTAATGGCTATGGCGTTGCAACGTCGCGGCATAAACGCGAGATCCCTGACTGGCGA
TCAAGTCCAAATTCATACAAACAGTCAGTTTGGTCGGGCGAGTATTGAGCGTGTCGATACGGCATACTTAACGTCTTTGC
TGAACGACGGCATTGTGCCGATTGTGGCCGGCTTTCAAGGTATAGATCCCAATGGTGACGTAACAACCTTAGGGCGCGGC
GGTTCTGATACTACGGCTGTGGCACTTGCTGCGGCGTTAAAAGCCGATGAATGCCAAATCTTTACCGATGTGCCTGGTGT
TTTTACTACCGATCCTAATATCGATAGTAGCGCCAGACGCCTCGATGTGATTGGTTTTGATGTGATGCTAGAAATGGCAA
AACTCGGCGCTAAGGTGTTGCATCCCGATTCAGTTGAATACGCACAGCGTTTTAAAGTGCCACTGCGTGTATTATCGAGC
TTTGAGGCAGGCCATGGGACATTGATCCAATTTGGTGACGAATCAGAGCTGGCGATGGCGGCATCTGTGCAAGGCATTGC
GATTAATAAGGCGCTCGCGACCTTAACCATAAAAGGTTTGTTTACCAGTAGTGAGCATTATCAAGCACTGTTAGCTTGCT
TGGCACGGCTTGAGATTGATGTTGAGTTTATTACCCCGCTCAAACTCAATGAAACCTCAGCAGCCGAATGTGTCAGTTTT
ATGCTGGCCGAAGCCAAGGTCGATATTTTATTGCATGAGCTAGAGCTTTTAAGTGAAAGTCTTGATCTAGGCCAATTGAT
TGTTGAGCGCCAACGTGCAAAAGTGTCTTTAGTTGGCAAAGGTTTACAGGCAAAAGTTGGATTATTGACTAAGATGTTAG
ATGTATTGGGTAATGAAACAATCCATGCTAAGTTACTTTCGACATCGGAGAGTAAATTGTCAACTGTGATCGATGAAAGG
GACTTACACAAGGCGGTTCGGGCGCTACATCACGCTTTCGAGCTAAATAAGGTGTAA

Upstream 100 bases:

>100_bases
TGATATGGCCCAAGCGGGTGGTAGCCAGCCAGAAAATCTGGATGCGGCACTGTCTCAAGTATTACCTTGGATTACTGAGC
GTTTAGCTTAAGAGGTTGCT

Downstream 100 bases:

>100_bases
TTAAATAACCGTTTGAGTATTGAATACTATTAATTTGTACTCAGCTGACCCTATAATAAGCCCATCTACCGGATGAGTGC
CGTGTGTAAGCTGAATTAAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLEKRKLSGSKLFVKKFGGTSVGSIERIEVVAEQIAKSAHNGELQVLVLSAMAGETNRLFALAAQIDPRASARELDMLVS
TGEQISIALMAMALQRRGINARSLTGDQVQIHTNSQFGRASIERVDTAYLTSLLNDGIVPIVAGFQGIDPNGDVTTLGRG
GSDTTAVALAAALKADECQIFTDVPGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAQRFKVPLRVLSS
FEAGHGTLIQFGDESELAMAASVQGIAINKALATLTIKGLFTSSEHYQALLACLARLEIDVEFITPLKLNETSAAECVSF
MLAEAKVDILLHELELLSESLDLGQLIVERQRAKVSLVGKGLQAKVGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDER
DLHKAVRALHHAFELNKV

Sequences:

>Translated_418_residues
MLEKRKLSGSKLFVKKFGGTSVGSIERIEVVAEQIAKSAHNGELQVLVLSAMAGETNRLFALAAQIDPRASARELDMLVS
TGEQISIALMAMALQRRGINARSLTGDQVQIHTNSQFGRASIERVDTAYLTSLLNDGIVPIVAGFQGIDPNGDVTTLGRG
GSDTTAVALAAALKADECQIFTDVPGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAQRFKVPLRVLSS
FEAGHGTLIQFGDESELAMAASVQGIAINKALATLTIKGLFTSSEHYQALLACLARLEIDVEFITPLKLNETSAAECVSF
MLAEAKVDILLHELELLSESLDLGQLIVERQRAKVSLVGKGLQAKVGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDER
DLHKAVRALHHAFELNKV
>Mature_418_residues
MLEKRKLSGSKLFVKKFGGTSVGSIERIEVVAEQIAKSAHNGELQVLVLSAMAGETNRLFALAAQIDPRASARELDMLVS
TGEQISIALMAMALQRRGINARSLTGDQVQIHTNSQFGRASIERVDTAYLTSLLNDGIVPIVAGFQGIDPNGDVTTLGRG
GSDTTAVALAAALKADECQIFTDVPGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAQRFKVPLRVLSS
FEAGHGTLIQFGDESELAMAASVQGIAINKALATLTIKGLFTSSEHYQALLACLARLEIDVEFITPLKLNETSAAECVSF
MLAEAKVDILLHELELLSESLDLGQLIVERQRAKVSLVGKGLQAKVGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDER
DLHKAVRALHHAFELNKV

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=454, Percent_Identity=31.9383259911894, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1786183, Length=350, Percent_Identity=30.8571428571429, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=432, Percent_Identity=25, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44954; Mature: 44954

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRKLSGSKLFVKKFGGTSVGSIERIEVVAEQIAKSAHNGELQVLVLSAMAGETNRLF
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEE
ALAAQIDPRASARELDMLVSTGEQISIALMAMALQRRGINARSLTGDQVQIHTNSQFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
SIERVDTAYLTSLLNDGIVPIVAGFQGIDPNGDVTTLGRGGSDTTAVALAAALKADECQI
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEE
FTDVPGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAQRFKVPLRVLSS
EECCCCCEECCCCCCCCHHEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
FEAGHGTLIQFGDESELAMAASVQGIAINKALATLTIKGLFTSSEHYQALLACLARLEID
CCCCCCCEEEECCCCCHHHHHCCCCEEEHHHEEEEEEEEEECCCHHHHHHHHHHHHHCCE
VEFITPLKLNETSAAECVSFMLAEAKVDILLHELELLSESLDLGQLIVERQRAKVSLVGK
EEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEECC
GLQAKVGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEKRKLSGSKLFVKKFGGTSVGSIERIEVVAEQIAKSAHNGELQVLVLSAMAGETNRLF
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEE
ALAAQIDPRASARELDMLVSTGEQISIALMAMALQRRGINARSLTGDQVQIHTNSQFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
SIERVDTAYLTSLLNDGIVPIVAGFQGIDPNGDVTTLGRGGSDTTAVALAAALKADECQI
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEE
FTDVPGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAQRFKVPLRVLSS
EECCCCCEECCCCCCCCHHEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
FEAGHGTLIQFGDESELAMAASVQGIAINKALATLTIKGLFTSSEHYQALLACLARLEID
CCCCCCCEEEECCCCCHHHHHCCCCEEEHHHEEEEEEEEEECCCHHHHHHHHHHHHHCCE
VEFITPLKLNETSAAECVSFMLAEAKVDILLHELELLSESLDLGQLIVERQRAKVSLVGK
EEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEECC
GLQAKVGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]