Click here to switch to the map view.

The map label for this gene is ribD [H]

Identifier: 117919545

GI number: 117919545

Start: 1290407

End: 1291552

Strand: Direct

Name: ribD [H]

Synonym: Shewana3_1096

Alternate gene names: 117919545

Gene position: 1290407-1291552 (Clockwise)

Preceding gene: 117919544

Following gene: 117919546

Centisome position: 25.95

GC content: 51.92

Gene sequence:

>1146_bases
ATGAATTGGTCAGAACTCGATAACCAGATGATGAGCCGAGCCATACAACTGGCTCGCAAAGGTTTTTATACCACTCGCCC
CAATCCCAGTGTGGGCTGCGTTATCGTAAAAGATAATCAGATTGTCGGTGAAGGTTATCATCAAAAAGCCGGCGAGCCCC
ACGCCGAGGTGCATGCACTGCGCATGGCTGGCGAGCTTGCCCGTGGCGCGACCGCCTATGTCACCTTAGAACCTTGCAGC
CATTATGGCCGCACACCGCCGTGTGCCTTGGCGCTGATCAATATTGGTGTAAAACGTGTAGTGGTCGCGGTTGAAGATCC
CAATCCGCAGGTCGGTGGTCGCGGTATTCAAATGCTGCGCGATGCGGGCATTGAAGTGGATGTCGGCTTACATCGCGACG
AAGCTTATGCTTTAAATCTTGGTTTTATGAAGCGCATGGAATCGGGCTTACCTTGGGTGACGGTAAAGCTTGCCGCGAGT
CTCGATGGTAAAACCGCATTATCCAACGGTGTCTCTAAGTGGATTACAGGCCCCGAAGCTCGCCGCGATGTGCAGCGCTT
ACGTTTGCGCGCCTGTGCACTGGTCACTGGGATTGAAACCGTACTGGCCGATGCCCCTTCGCTTAATGTGCGCTACTCAG
AGCTTGGCAGTCTTAACTTGCAATTGAGTGAAGCGCAAATTTTACAACCGCTGCGGGTGATTTTAGATAGTCGTTGCCGC
ATGCCGATTACGGCAGCCTTGCTTGCGATTGAATCGCCGATTTTATTAGTCTCAACAGAGCCTTACTCGCCAGCCTTTAT
GGCGCAGTTGCCTGCCCATGTGACTTGTCTTCAATTACCGGCGATTGATGGTCGAATCTCGCTGCCTGCACTCTTAAGCT
ATTTAGGCAAAAGCTGTAATCAGGTGCTTATCGAAGCGGGCGCGACCTTAGCCGGCGCCTTTATCGGTGACGGATTAGCC
GATGAGTTAGTGCTGTATCAAGCGATGAAAATCCTTGGGGCACAAGGACGTAATCTACTCGAATTACCCGATTATCAAAT
GATGGCCGATATTCCGACCCTCAAACTGGTCGATGAGCGTAAAGTGGGCGCGGATATGCGTTTCACCTTGCGGCTCACGT
CCAATCCATCTTTAGCGAATAAGTGA

Upstream 100 bases:

>100_bases
GGCGATTGCGAAACTGCAAAAGTAACGTGGGTTATCTTAGGTTAGTGCTTAGGTTAGCGCCTTGTTCGGGCACGCTTCCT
CAAGATTTCATAGGGTTTAT

Downstream 100 bases:

>100_bases
GTTAACCATGTTTACTGGGATTATTGAGGCCGTAGGCACGCTGCGAAAGCTTGAACGTAAAGGCGATGATATTCGTTTGA
CGGTCGCCAGTGGCAAACTG

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADMRFTLRLTSNPSLANK

Sequences:

>Translated_381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADMRFTLRLTSNPSLANK
>Mature_381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADMRFTLRLTSNPSLANK

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=362, Percent_Identity=51.9337016574586, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI145693172, Length=152, Percent_Identity=34.2105263157895, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41257; Mature: 41257

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHAL
CCHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEECCEEECCCCHHCCCCCHHHHHHH
RMAGELARGATAYVTLEPCSHYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLR
HHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHH
DAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAASLDGKTALSNGVSKWITGPEA
HCCCEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCHHHHCCCHHH
RRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCEEEEECHHHHHHHHHHHHCCCCC
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCN
CCHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
QVLIEAGATLAGAFIGDGLADELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDER
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEECCC
KVGADMRFTLRLTSNPSLANK
CCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHAL
CCHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEECCEEECCCCHHCCCCCHHHHHHH
RMAGELARGATAYVTLEPCSHYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLR
HHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHH
DAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAASLDGKTALSNGVSKWITGPEA
HCCCEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCHHHHCCCHHH
RRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCEEEEECHHHHHHHHHHHHCCCCC
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCN
CCHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
QVLIEAGATLAGAFIGDGLADELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDER
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEECCC
KVGADMRFTLRLTSNPSLANK
CCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]