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The map label for this gene is maeA [H]

Identifier: 117919202

GI number: 117919202

Start: 869557

End: 871245

Strand: Reverse

Name: maeA [H]

Synonym: Shewana3_0750

Alternate gene names: 117919202

Gene position: 871245-869557 (Counterclockwise)

Preceding gene: 117919203

Following gene: 117919199

Centisome position: 17.52

GC content: 49.56

Gene sequence:

>1689_bases
ATGGACGATAATAAACGCCCCCTCTATCTTCCGTTTGCAGGACCTGCCATTCTTGAAGCTCCCTTAATTAACAAGGGCAG
TGCATTTTCGGAAGAAGAGCGTATTTTCTTTAACCTCGAAGGCTTAGTACCCTACGCCATTGAAACTATTGAAGAACAGG
CTTCACGCGCCTACGATCAGTTCAGAAGTTTCAATAACGATCTCGATAAGCACATCTATCTGCGCAACATTCAAGACACC
AACGAAACCCTGTTTTATCGTTTAGTGCAAAACCACATCAGCGAAATGATGCCAATTATCTACACCCCGACGGTAGGTTT
GGCCTGTGAGCGCTTCTCGAAAAACTATCGCCGTAACCGTGGTCTGTTCATCTCTTACCCGAATAAGGACAGAATCGACG
ACATCCTCAATAACTCGACTCGCCAAAAAGTAAAAATCATCGTTGTGACCGACGGTGAGCGCATCTTAGGCTTAGGCGAC
CAAGGTATTGGCGGCATGGGGATCCCGATTGGTAAATTGTCACTCTACACCAGCTGTGGTGGGATCAGCCCCGCATACAC
ACTGCCAATTACCTTAGACGTAGGTACCGATAATCCACAGTTGCTGGAAGATCCTATGTACATGGGTTGGCGCCATCCGC
GTATTGGCGGCGAGGAGTATGCCGAGTTTATCGAAGCCTTTATGCAAGCCGTGCATGTACGTTGGCCAGATACACTGATC
CAATTCGAAGACTTTGCCCAAAAGAATGCGATGCCAATCCTTGAGCGTTATAAGGATCGCTACTGCTGCTTTAACGATGA
CATTCAAGGTACCGCCGCCGTGACTGTGGGCTCGTTACTCGCCGCCTGTAAAGCCGCGGGCACTGAGCTCAACAAACAAC
GTATCGCCTTCTTAGGTGCCGGTAGCGCAGGCTGCGGTATTGCCGAAGCCATCGTTGCGCAAATGGTGTCTGAAGGGATC
AGCGATGAGCAAGCCCGCAGCCAAGTCTGCATGGTTGACCGTTGGGGCCTGCTGCTTGACAACATGCCTAACCTGTTGCC
ATTCCAACAAAAATTGGCTCAAAAATGTGCCGATATCTGCAACTGGAATAACTTCAGCGACAATATTTCACTGCTCGATG
TGGTCAATAACGCTAAACCAACGGTACTGATTGGCGTATCGGGCGCACCAGGTCTGTTTACCGAAGAAATTGTTCGTGCA
ATGCATAGCCACTGCGAACGCCCAATTATCTTCCCACTGTCAAACCCCACCAGCCGTGTTGAAGCGACGCCAAAAGACAT
TCTGCACTGGACGTCTGGCCAAGCCTTAGTGGCAACGGGTAGCCCGTTTGAACCTGTTGTTGTCGATGGCGAAACCTATG
AAATCGCGCAATGTAACAACAGCTTTATCTTCCCTGGTATTGGTTTAGGGGTACTCGCCTCGGGTGCTCGCCATGTCTCC
GATGCGATGTTAATGGCATCGAGCCGCGCGCTCGCCGAATGCTCACCGTTAGCCATTAATGGCTCAGGACCACTCCTGCC
AAAACTGGAAGATATTCACTCAGTAAGTAAGCATATTGCGTTTGCCGTCGGTAAAGTGGCGATTGAACAAGGCCTATCCT
TACCTGCAAGTGATGAGCTGCTGATGCAATCTATCGAAGATAATTTCTGGAAGCCAGAGTATCGCCGTTATAAGCGTACG
TCTTTCTAA

Upstream 100 bases:

>100_bases
GACACAGGCAACAAAGATCACATTTCATGATAACCTTACGTGACTTACAGCACGTCTCAAGCACGTACCGAACCATTAAA
CAATAACTCAAAGGTTACCC

Downstream 100 bases:

>100_bases
TATCAGACATTATTCCAATAAAAAGCCCGTCAATCGACGGGCTTTTTATTGGGTCAAACTCACAGCTTAAGGCGCCATCA
CCTGTTTAAAGCTGTTGAGC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADICNWNNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIVRA
MHSHCERPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDELLMQSIEDNFWKPEYRRYKRT
SF

Sequences:

>Translated_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADICNWNNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIVRA
MHSHCERPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDELLMQSIEDNFWKPEYRRYKRT
SF
>Mature_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADICNWNNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIVRA
MHSHCERPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDELLMQSIEDNFWKPEYRRYKRT
SF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=519, Percent_Identity=43.5452793834297, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI62420882, Length=563, Percent_Identity=41.2078152753108, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI62420880, Length=563, Percent_Identity=41.2078152753108, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI239049447, Length=563, Percent_Identity=41.2078152753108, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI4505145, Length=552, Percent_Identity=42.2101449275362, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=45.5723542116631, Blast_Score=397, Evalue=1e-110,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=67.741935483871, Blast_Score=788, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=547, Percent_Identity=43.327239488117, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322823, Length=565, Percent_Identity=43.5398230088496, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21356279, Length=519, Percent_Identity=44.7013487475915, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281362672, Length=519, Percent_Identity=44.7013487475915, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281362674, Length=519, Percent_Identity=44.7013487475915, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24646388, Length=512, Percent_Identity=42.7734375, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646386, Length=512, Percent_Identity=42.7734375, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363505, Length=535, Percent_Identity=37.3831775700935, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707236, Length=535, Percent_Identity=37.3831775700935, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=38.1139489194499, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363503, Length=543, Percent_Identity=36.8324125230203, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707240, Length=516, Percent_Identity=39.922480620155, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707242, Length=537, Percent_Identity=39.1061452513966, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707238, Length=537, Percent_Identity=39.1061452513966, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19922384, Length=543, Percent_Identity=29.8342541436464, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62188; Mature: 62188

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRIAFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADIC
CCCCCHHHHHHHHHHHHCCCCCHHHHHCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
NWNNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIVRAMHSHCERPIIFPLSNPTSRV
CCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHCCHHHHH
DAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDEL
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LMQSIEDNFWKPEYRRYKRTSF
HHHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRIAFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADIC
CCCCCHHHHHHHHHHHHCCCCCHHHHHCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
NWNNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIVRAMHSHCERPIIFPLSNPTSRV
CCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHCCHHHHH
DAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDEL
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LMQSIEDNFWKPEYRRYKRTSF
HHHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA