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The map label for this gene is cpxR [H]

Identifier: 117918710

GI number: 117918710

Start: 285338

End: 286024

Strand: Reverse

Name: cpxR [H]

Synonym: Shewana3_0253

Alternate gene names: 117918710

Gene position: 286024-285338 (Counterclockwise)

Preceding gene: 117918715

Following gene: 117918709

Centisome position: 5.75

GC content: 51.09

Gene sequence:

>687_bases
ATGAGTCGGATATTATTAATCGATGATGACCTTGGTTTATCAGAACTCCTCGGACAATTACTCGAACTCGAAGGGTTTAA
GCTCACGCTGGCCTACGATGGCAAGCAAGGCCTAGAACTGGCCCTAGCGGGGGATTACGATCTGATCTTACTCGATGTGA
TGTTACCTAAATTAAACGGTTTTGAAGTGCTACGCGCCCTGCGCCAACACAAGCAAACGCCAGTGCTGATGCTCACCGCC
AGAGGCGATGAGATTGACCGAGTGGTTGGCCTTGAGATCGGTGCCGATGACTATTTACCTAAACCCTTCAATGACAGAGA
GCTTATCGCTCGGATTCGCGCCATCATTCGCCGTTCACACTTAACCGCCCAAGAGATCCACGCCACCCCGGCGCAGGAGT
TTGGTGATCTACGCTTAGATCCCTCACGCCAAGAAGCCTACTGCAATGAGCAGCTGATTATTCTGACGGGAACCGAGTTT
ACCCTGCTACACACGCTAGCGCTGCATGCGGGTGAGTTGATGAATAAAGAAGAGCTTAACGAGATAGTGCTCGGCAAAAA
ACTCATGCCCTTCGACCGCAGCCTAGATATGCACCTCTCGAATCTACGCAAAAAACTCCCCGAGCGAAGCGACGGCAGAC
CTAGGGTGAAAACCATCCGTGGCAAAGGCTATATCTGGCTACCATAA

Upstream 100 bases:

>100_bases
ACATCAAAAGAGGTATACTCAGGCAAAATACTCAAGCCGTCTGTGGTTTAGCACATCGCTTTGAGTCTTTCACACCAGTT
CACCCAGATTAAGGAACACT

Downstream 100 bases:

>100_bases
CGGCGGGAACAACTGTGCCTAATCGCTTATTTATCAAGTTACTACTCGGATTTTGGATCTGTAGCTCGCTGATTATCGCT
TTGGTCGGCCTGCTGCCATT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALAGDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSHLTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEF
TLLHTLALHAGELMNKEELNEIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP

Sequences:

>Translated_228_residues
MSRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALAGDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSHLTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEF
TLLHTLALHAGELMNKEELNEIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
>Mature_227_residues
SRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALAGDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTAR
GDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSHLTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFT
LLHTLALHAGELMNKEELNEIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=59.2105263157895, Blast_Score=255, Evalue=2e-69,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=38.6266094420601, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=38.9380530973451, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=38.9380530973451, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.1607142857143, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=37.7777777777778, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.7713004484305, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=37.3913043478261, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=31.5555555555556, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.6491228070175, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=32.7659574468085, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=34.6491228070175, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=206, Percent_Identity=32.0388349514563, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=30.9734513274336, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790437, Length=161, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.9449541284404, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25884; Mature: 25752

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALAGDYDLILLDVMLPKLNG
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEEHHHCCCCH
FEVLRALRQHKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSH
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
LTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFTLLHTLALHAGELMNKEELN
CCHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHH
EIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC
>Mature Secondary Structure 
SRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALAGDYDLILLDVMLPKLNG
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEEHHHCCCCH
FEVLRALRQHKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSH
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
LTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFTLLHTLALHAGELMNKEELN
CCHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHH
EIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]