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The map label for this gene is czcC [H]

Identifier: 117676323

GI number: 117676323

Start: 273644

End: 274927

Strand: Reverse

Name: czcC [H]

Synonym: Shewana3_4386

Alternate gene names: 117676323

Gene position: 274927-273644 (Counterclockwise)

Preceding gene: 117676324

Following gene: 117676322

Centisome position: 98.56

GC content: 46.03

Gene sequence:

>1284_bases
ATGAGAGACTTGCTTTTTAACGTCAGAACTAAAAAACCGATTGGCTATCGGTTTTCCTCCATTGTGCTAGGAATGTGTTT
AGTATTCCCTGCCGTTGCGGTATCGAATGAAGCGCCACAAACACTCACCTTAGCCGATGCTGTGACTTTGACACTTCTGC
AACACCCAGAATTACAGATTTTCAACTCGCAGCAGCGCGTGATGGAAGGGCGAATACAGCAGGCAAGTGTCGGTGAGCGG
CCTGAAATAGGTTTGATGATTGAGGATGCTCTGGGTACTGGTGAACACAGTGCTCTGAAAAGTATGCAATCTACGCTCAG
TTTTTCATGGTTACTGCAACAAGATTTGATTGATAGTCGTGTTAACACGGCTAAAACAGAGGCCACTCAATTAGATATAG
AAAAACAAATCAAAGCCTTGGATTTGTCTTCACAGGTGGCTAAACATTTTATTGATTTGTTAGTGAAGCAAGAACGCCTC
AAGCTCAATCTGATAGCAGAAAAGCAGGCAAAAGAGGTTGTCAAAACCGTTGCTAAACGTGTGCAAGCGGGAAAGAGTTC
TGCGGTTGAAACACAGTTGGCAAAGGCTGAGCTTATCCGTCGTGGCTTGGCCGTCGAAGATATCGAGCATGAACTCAAAG
CCAGCCAATATCAATTGGCATCACAGTGGGGAAAGCCTAAGGCATCCTATCGTTTCAACGGCAATCTGCTTGATATGCCT
GCTGTGCCATCAGTTGACAGTCAGCTTAACTTGTTAAAAAAGCATCCTCGTTTTCAACAGTTTGCGACTGCGCAACGCAT
TGCTCAATCGCAAATGGAGCTCGCACGAATAGAAGCTAAGCCGCAGTGGCAAGTGACCGCTGGCGTGAGGCGCTATGAGG
CGAGTGATGATTTTGGCTTAGTCGCGGGTATTTCTATCCCTTGGGGTTCAAGTGACCGTAATGCGGGAACCATAGCCGCC
TTACAAGCACAGCAAGATGTACTCGCCAATGAGCAAAACGCATTAATGCAGGCTCAGGATGCCCAGTTGTATGTGCTGTT
ACAGGAAATGGCACATTCTGCACATGTTATCGATACAGTGCGCAGTGACATAGTGCCAACCCTTGAAAAAGCTCTGTCTG
AGGCAAGCAATGCCTTTGATAAAGGTCTGCTCAGCTACAACCAATACAATGACGTGTATCGGGAATTACTCAGTGCTCAA
TATCAGTTGCTGGATGCCTTTGAAAGTTTGCATTTACAACACATTGAAATTCAACGCCTAACGGGCACATCCATTTCTCA
GTGA

Upstream 100 bases:

>100_bases
TTGTTATTCTTAGCCATCGTCCCACTTTTAACCGCTTCAACTGTCGATAGCCTTCACCACATTATCGAAACCTTCTTCAC
CCATTAATTAAGGATTGGGA

Downstream 100 bases:

>100_bases
GATTACCTATGAAGAATAACAACACCTTTTCGTCATTGAGTTTGGCGATACTGCTCAGTCTGGGTATTAATGCCGTCGCT
TCAACACCTTTAATGGCATC

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRDLLFNVRTKKPIGYRFSSIVLGMCLVFPAVAVSNEAPQTLTLADAVTLTLLQHPELQIFNSQQRVMEGRIQQASVGER
PEIGLMIEDALGTGEHSALKSMQSTLSFSWLLQQDLIDSRVNTAKTEATQLDIEKQIKALDLSSQVAKHFIDLLVKQERL
KLNLIAEKQAKEVVKTVAKRVQAGKSSAVETQLAKAELIRRGLAVEDIEHELKASQYQLASQWGKPKASYRFNGNLLDMP
AVPSVDSQLNLLKKHPRFQQFATAQRIAQSQMELARIEAKPQWQVTAGVRRYEASDDFGLVAGISIPWGSSDRNAGTIAA
LQAQQDVLANEQNALMQAQDAQLYVLLQEMAHSAHVIDTVRSDIVPTLEKALSEASNAFDKGLLSYNQYNDVYRELLSAQ
YQLLDAFESLHLQHIEIQRLTGTSISQ

Sequences:

>Translated_427_residues
MRDLLFNVRTKKPIGYRFSSIVLGMCLVFPAVAVSNEAPQTLTLADAVTLTLLQHPELQIFNSQQRVMEGRIQQASVGER
PEIGLMIEDALGTGEHSALKSMQSTLSFSWLLQQDLIDSRVNTAKTEATQLDIEKQIKALDLSSQVAKHFIDLLVKQERL
KLNLIAEKQAKEVVKTVAKRVQAGKSSAVETQLAKAELIRRGLAVEDIEHELKASQYQLASQWGKPKASYRFNGNLLDMP
AVPSVDSQLNLLKKHPRFQQFATAQRIAQSQMELARIEAKPQWQVTAGVRRYEASDDFGLVAGISIPWGSSDRNAGTIAA
LQAQQDVLANEQNALMQAQDAQLYVLLQEMAHSAHVIDTVRSDIVPTLEKALSEASNAFDKGLLSYNQYNDVYRELLSAQ
YQLLDAFESLHLQHIEIQRLTGTSISQ
>Mature_427_residues
MRDLLFNVRTKKPIGYRFSSIVLGMCLVFPAVAVSNEAPQTLTLADAVTLTLLQHPELQIFNSQQRVMEGRIQQASVGER
PEIGLMIEDALGTGEHSALKSMQSTLSFSWLLQQDLIDSRVNTAKTEATQLDIEKQIKALDLSSQVAKHFIDLLVKQERL
KLNLIAEKQAKEVVKTVAKRVQAGKSSAVETQLAKAELIRRGLAVEDIEHELKASQYQLASQWGKPKASYRFNGNLLDMP
AVPSVDSQLNLLKKHPRFQQFATAQRIAQSQMELARIEAKPQWQVTAGVRRYEASDDFGLVAGISIPWGSSDRNAGTIAA
LQAQQDVLANEQNALMQAQDAQLYVLLQEMAHSAHVIDTVRSDIVPTLEKALSEASNAFDKGLLSYNQYNDVYRELLSAQ
YQLLDAFESLHLQHIEIQRLTGTSISQ

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47530; Mature: 47530

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLLFNVRTKKPIGYRFSSIVLGMCLVFPAVAVSNEAPQTLTLADAVTLTLLQHPELQI
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEE
FNSQQRVMEGRIQQASVGERPEIGLMIEDALGTGEHSALKSMQSTLSFSWLLQQDLIDSR
ECCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTAKTEATQLDIEKQIKALDLSSQVAKHFIDLLVKQERLKLNLIAEKQAKEVVKTVAKR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQAGKSSAVETQLAKAELIRRGLAVEDIEHELKASQYQLASQWGKPKASYRFNGNLLDMP
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCC
AVPSVDSQLNLLKKHPRFQQFATAQRIAQSQMELARIEAKPQWQVTAGVRRYEASDDFGL
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCE
VAGISIPWGSSDRNAGTIAALQAQQDVLANEQNALMQAQDAQLYVLLQEMAHSAHVIDTV
EEEEECCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RSDIVPTLEKALSEASNAFDKGLLSYNQYNDVYRELLSAQYQLLDAFESLHLQHIEIQRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
TGTSISQ
CCCCCCC
>Mature Secondary Structure
MRDLLFNVRTKKPIGYRFSSIVLGMCLVFPAVAVSNEAPQTLTLADAVTLTLLQHPELQI
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEE
FNSQQRVMEGRIQQASVGERPEIGLMIEDALGTGEHSALKSMQSTLSFSWLLQQDLIDSR
ECCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTAKTEATQLDIEKQIKALDLSSQVAKHFIDLLVKQERLKLNLIAEKQAKEVVKTVAKR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQAGKSSAVETQLAKAELIRRGLAVEDIEHELKASQYQLASQWGKPKASYRFNGNLLDMP
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCC
AVPSVDSQLNLLKKHPRFQQFATAQRIAQSQMELARIEAKPQWQVTAGVRRYEASDDFGL
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCE
VAGISIPWGSSDRNAGTIAALQAQQDVLANEQNALMQAQDAQLYVLLQEMAHSAHVIDTV
EEEEECCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RSDIVPTLEKALSEASNAFDKGLLSYNQYNDVYRELLSAQYQLLDAFESLHLQHIEIQRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
TGTSISQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]