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The map label for this gene is czcC [H]

Identifier: 117676096

GI number: 117676096

Start: 17444

End: 18784

Strand: Reverse

Name: czcC [H]

Synonym: Shewana3_4156

Alternate gene names: 117676096

Gene position: 18784-17444 (Counterclockwise)

Preceding gene: 117676097

Following gene: 117676095

Centisome position: 6.73

GC content: 56.45

Gene sequence:

>1341_bases
ATGCTATCAATACGTACTGCGCCGGGTTCTGGCGCTTTGGGGCGGAGGAATATCAAAAGCCGATGTATTCTGTTCAGTTT
ATTATTTTTCATTTCTTCGTCGGGGCTTAGCGCCGAGCCTGGGGACTCAACGATCACGCTGACCAATGCGGTGCAGCGCG
CCTTGTCACAAAACCCGTCTTTGAAAGTTTTTCCCTACCGCTACGCAGCCCTTCAAGGGCAGGCCGAAACAGCCGGGTTA
AGACCGGCGTATGAGCTGGGATTTGACGCTGAAAATGTCGGGGGCACTGGGGACTTCAGCGGCGCAAGTGGTGCTGAACT
CACCATTGCGCTGTCTTCGGTCATCGAAATGGGGGATAAGCGCGCGGCACGGCAAGGCGTAATCTCCCACAGTCGGTCGG
TGCTCAATGCCAGCCGACAGGTGGAATCCTTGGCCTTATTGGGCGAAGTCACCCGCCGTTACGTCGATGTGCTAGCGGCA
CAGGAGCAGGTCACCCTGGCTGGCGAGGCCGCCCAGTTGGCGAGCGAGAGCTTACGCATTGTGAAAAAGCGGGCTACGGC
GGGAGCGACACCCGAGGCGGAAGTCAAACGGGCACAGGCCGCTGCCGAGCAAGCGAAGCTCGCTTTGCTTTCGGAGCAGC
AACGGCTTGCTTATTTGAAAGTGTCGTTGTCTGCCCTGTGGGGGGTAACCTCACCGGACTTTGACAAAGTGGAAGGTGAT
CTATTCCAGTTTGGCGAGGACGTGGCATTCGACCTGTTGTACGCCAAAGTTGAAAAAAATCCTGCGATAGAAGTATTCGC
AGCAGAGTCCCGCCTCAAAGAAGCAGAAATACGCCTTGCTCAAACCCAATCCAGTGCCGATATCAGTTGGTCGGTGGGGG
TTCGTCGCTTGCAGGAAACCGATGACACCGCGTTGGTAGCGGGTTTCAGCATGCCGTTGTTTTCCGGCAAGCGAAATGTC
GGCGCCGTTTCGACCGCGTTGGCCGAAAAAAATCAGGTGTTGGCAGAGCGCGATGTAATGCTGCTGGATCTACACACGCA
ACTGTTCCGGGCTTTTCACAACCGCAAACAAGCCATTGTCGCGGTAGAGGCACTGCGCACCGCCATCATTCCCGCCCTTG
AGCAGGCCCTGGTAGAAACTCAGGCGGCCTATCAACGCGGTCGCTACGGGTATCTCGACTATGTCAGCGCGCGGCAGGAA
TTATTGAGCGCCAGGCGCACCCAGATCGAAGCGGCCGCAGCCGCCTTAACCTATGGTGCAGAAATTGAGCAGCTAACAGC
AGAGCCCTTGGCCTTGACACAGTATGGCGAAGACAACACATTTTCAGGAACCCCACAATGA

Upstream 100 bases:

>100_bases
GCCCTCCAATCGCCTGATTTTACCGATTATGTTTTTTCTGTGTTGCCGTTATCGTTGCAACGCGCGGTTTGAATTATCTT
AAATAAGTAGGATCTACCAT

Downstream 100 bases:

>100_bases
AATCAAATACCCAGTTAAAAAAATCATTTATCCGTCTAATTACGTGTTGCTTTGCGATCACCCTGTTGTCTGGACAAACT
TTCGCCGAGACGGGTCACGG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MLSIRTAPGSGALGRRNIKSRCILFSLLFFISSSGLSAEPGDSTITLTNAVQRALSQNPSLKVFPYRYAALQGQAETAGL
RPAYELGFDAENVGGTGDFSGASGAELTIALSSVIEMGDKRAARQGVISHSRSVLNASRQVESLALLGEVTRRYVDVLAA
QEQVTLAGEAAQLASESLRIVKKRATAGATPEAEVKRAQAAAEQAKLALLSEQQRLAYLKVSLSALWGVTSPDFDKVEGD
LFQFGEDVAFDLLYAKVEKNPAIEVFAAESRLKEAEIRLAQTQSSADISWSVGVRRLQETDDTALVAGFSMPLFSGKRNV
GAVSTALAEKNQVLAERDVMLLDLHTQLFRAFHNRKQAIVAVEALRTAIIPALEQALVETQAAYQRGRYGYLDYVSARQE
LLSARRTQIEAAAAALTYGAEIEQLTAEPLALTQYGEDNTFSGTPQ

Sequences:

>Translated_446_residues
MLSIRTAPGSGALGRRNIKSRCILFSLLFFISSSGLSAEPGDSTITLTNAVQRALSQNPSLKVFPYRYAALQGQAETAGL
RPAYELGFDAENVGGTGDFSGASGAELTIALSSVIEMGDKRAARQGVISHSRSVLNASRQVESLALLGEVTRRYVDVLAA
QEQVTLAGEAAQLASESLRIVKKRATAGATPEAEVKRAQAAAEQAKLALLSEQQRLAYLKVSLSALWGVTSPDFDKVEGD
LFQFGEDVAFDLLYAKVEKNPAIEVFAAESRLKEAEIRLAQTQSSADISWSVGVRRLQETDDTALVAGFSMPLFSGKRNV
GAVSTALAEKNQVLAERDVMLLDLHTQLFRAFHNRKQAIVAVEALRTAIIPALEQALVETQAAYQRGRYGYLDYVSARQE
LLSARRTQIEAAAAALTYGAEIEQLTAEPLALTQYGEDNTFSGTPQ
>Mature_446_residues
MLSIRTAPGSGALGRRNIKSRCILFSLLFFISSSGLSAEPGDSTITLTNAVQRALSQNPSLKVFPYRYAALQGQAETAGL
RPAYELGFDAENVGGTGDFSGASGAELTIALSSVIEMGDKRAARQGVISHSRSVLNASRQVESLALLGEVTRRYVDVLAA
QEQVTLAGEAAQLASESLRIVKKRATAGATPEAEVKRAQAAAEQAKLALLSEQQRLAYLKVSLSALWGVTSPDFDKVEGD
LFQFGEDVAFDLLYAKVEKNPAIEVFAAESRLKEAEIRLAQTQSSADISWSVGVRRLQETDDTALVAGFSMPLFSGKRNV
GAVSTALAEKNQVLAERDVMLLDLHTQLFRAFHNRKQAIVAVEALRTAIIPALEQALVETQAAYQRGRYGYLDYVSARQE
LLSARRTQIEAAAAALTYGAEIEQLTAEPLALTQYGEDNTFSGTPQ

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 48009; Mature: 48009

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIRTAPGSGALGRRNIKSRCILFSLLFFISSSGLSAEPGDSTITLTNAVQRALSQNPS
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCC
LKVFPYRYAALQGQAETAGLRPAYELGFDAENVGGTGDFSGASGAELTIALSSVIEMGDK
EEEEEEHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
RAARQGVISHSRSVLNASRQVESLALLGEVTRRYVDVLAAQEQVTLAGEAAQLASESLRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHH
VKKRATAGATPEAEVKRAQAAAEQAKLALLSEQQRLAYLKVSLSALWGVTSPDFDKVEGD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCH
LFQFGEDVAFDLLYAKVEKNPAIEVFAAESRLKEAEIRLAQTQSSADISWSVGVRRLQET
HHHHCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCC
DDTALVAGFSMPLFSGKRNVGAVSTALAEKNQVLAERDVMLLDLHTQLFRAFHNRKQAIV
CCCEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCHHHHH
AVEALRTAIIPALEQALVETQAAYQRGRYGYLDYVSARQELLSARRTQIEAAAAALTYGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIEQLTAEPLALTQYGEDNTFSGTPQ
HHHHHCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLSIRTAPGSGALGRRNIKSRCILFSLLFFISSSGLSAEPGDSTITLTNAVQRALSQNPS
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCC
LKVFPYRYAALQGQAETAGLRPAYELGFDAENVGGTGDFSGASGAELTIALSSVIEMGDK
EEEEEEHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
RAARQGVISHSRSVLNASRQVESLALLGEVTRRYVDVLAAQEQVTLAGEAAQLASESLRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHH
VKKRATAGATPEAEVKRAQAAAEQAKLALLSEQQRLAYLKVSLSALWGVTSPDFDKVEGD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCH
LFQFGEDVAFDLLYAKVEKNPAIEVFAAESRLKEAEIRLAQTQSSADISWSVGVRRLQET
HHHHCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCC
DDTALVAGFSMPLFSGKRNVGAVSTALAEKNQVLAERDVMLLDLHTQLFRAFHNRKQAIV
CCCEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCHHHHH
AVEALRTAIIPALEQALVETQAAYQRGRYGYLDYVSARQELLSARRTQIEAAAAALTYGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIEQLTAEPLALTQYGEDNTFSGTPQ
HHHHHCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]