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The map label for this gene is norM [H]

Identifier: 116873281

GI number: 116873281

Start: 1896395

End: 1897765

Strand: Direct

Name: norM [H]

Synonym: lwe1865

Alternate gene names: 116873281

Gene position: 1896395-1897765 (Clockwise)

Preceding gene: 116873277

Following gene: 116873299

Centisome position: 67.39

GC content: 37.42

Gene sequence:

>1371_bases
TTGCAACAAACAGTCACATATGGAGCAAAATGGAAACAATTTTTAACAATATTTACACCAATAGTAATTACCCAACTCAC
ACTTTTCTCCATGACGTTTTTCGATACAACTATGAGTGGAAATTATTCGAATCAGGCGCTTGCTGGTGTGGCAATTGGTA
GTTCCTTTTGGGCTCCCGTGAATGCTGCTTTTTCCGGTTTACTGATGGCAATTACCCCTATTATTGCCCAGTTAATCGGT
GCAAAAAAAGAAAAAGAAGTCAAAAACACAGTGCATAACGGCCTATATATCGCATTATTGTTAGCTTTTATTTTAATTCT
TATTAATTTTATGGTCGTTCCTATGATTTTGACACATATGCCTGTTACAGCAGAAGTAGCGCATATTGCTCGCCATTTTT
TAAATGGGATTTGTATTGGAATTCCCGCTTTTTTTATTTCAGCGATTTTACGTTCTTTTATTGATTCGCTTGGTTTAACC
AGAGTGACAATGCTTATTACACTTTGTACCGTTCCCTTTAATATCTTTTTAAATTATTGCTTTATTTTTGGGAACTTTGG
TTTCCCGGAAATGGGTGGCGCTGGTAGTGGTTACGCAACGGGGATTACTTATTGGCTAGTCGTTTTAGTTAGCGTGATTT
TAATCCAAACGCAAACTAGATTACGCAAATTTGACATTTTTAAAGGCTTTACTGCACTTCATTTCTCCAAAATAAAGGAA
ATTATCGGGATTGGCGTTCCGAATGGTCTAACCATTTTATTTGAAACGAGTATTTTTTCAGCTGTGACAATTTTAATGGG
CGCTTTTGGGACAGAAACGATTGCCGCTCATCAATCAGCAAATAGTGTTTGTACATTGCTCTATGCCTTTCCGCTTAGTG
TCGCTTCTACACTAACCATTCTTGGTGGCTATGAAACCGGAGCTAAACGGTTAAAAGATGCTAAACAATATCGGCATATC
GGCATGACTGCTGCAATTTTAATTGGATTTATTAACGGTGCAATACTGTTTTTCTTCCGAGATATCATCGCTGGCTTTTA
CACGAATGATATAGAATTAATTGAGCTAATTAAGCATTTCTTAGTTTATGCGATACTCTTCCAATTCGCGGATGCTGTGT
TATCTCCAGTTCTAGGAGCATTAAGGGGATATAAAGATGTTACGGTTACTTCCGTTGTTGCCTTTATCTCCTATTGGTTG
ATTGGACTTCCGGTAGGTTATGGTTTATCGTTTACAAATTTAGGGCCATTTGGTTACTGGATAGGTTTAAGTACGGGACT
GTTTATCGCCGCATTTATTTTATCCATTCGAGTTCGCAAAACAGAACACAAACTTTCATTACAGGCAAAAAAAGCAGAGA
TTTCGAGCTAA

Upstream 100 bases:

>100_bases
CAAAGATAGTAAATATACGAAAGGAAAAGTTTTTTGGTTAGACTACCAGTTCACTTAATTTATGCTATAATCTGAATGGA
TACAAAAAGGAGATGATTAC

Downstream 100 bases:

>100_bases
TCTCTGCTTTTTTTTATTTGGCTAAACCATCATGAATTTTATCCAGATTGTAACGCATCATGTCCAAATATGTGTCACCT
TCCTGCCCTTTTTTCGCTGT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MQQTVTYGAKWKQFLTIFTPIVITQLTLFSMTFFDTTMSGNYSNQALAGVAIGSSFWAPVNAAFSGLLMAITPIIAQLIG
AKKEKEVKNTVHNGLYIALLLAFILILINFMVVPMILTHMPVTAEVAHIARHFLNGICIGIPAFFISAILRSFIDSLGLT
RVTMLITLCTVPFNIFLNYCFIFGNFGFPEMGGAGSGYATGITYWLVVLVSVILIQTQTRLRKFDIFKGFTALHFSKIKE
IIGIGVPNGLTILFETSIFSAVTILMGAFGTETIAAHQSANSVCTLLYAFPLSVASTLTILGGYETGAKRLKDAKQYRHI
GMTAAILIGFINGAILFFFRDIIAGFYTNDIELIELIKHFLVYAILFQFADAVLSPVLGALRGYKDVTVTSVVAFISYWL
IGLPVGYGLSFTNLGPFGYWIGLSTGLFIAAFILSIRVRKTEHKLSLQAKKAEISS

Sequences:

>Translated_456_residues
MQQTVTYGAKWKQFLTIFTPIVITQLTLFSMTFFDTTMSGNYSNQALAGVAIGSSFWAPVNAAFSGLLMAITPIIAQLIG
AKKEKEVKNTVHNGLYIALLLAFILILINFMVVPMILTHMPVTAEVAHIARHFLNGICIGIPAFFISAILRSFIDSLGLT
RVTMLITLCTVPFNIFLNYCFIFGNFGFPEMGGAGSGYATGITYWLVVLVSVILIQTQTRLRKFDIFKGFTALHFSKIKE
IIGIGVPNGLTILFETSIFSAVTILMGAFGTETIAAHQSANSVCTLLYAFPLSVASTLTILGGYETGAKRLKDAKQYRHI
GMTAAILIGFINGAILFFFRDIIAGFYTNDIELIELIKHFLVYAILFQFADAVLSPVLGALRGYKDVTVTSVVAFISYWL
IGLPVGYGLSFTNLGPFGYWIGLSTGLFIAAFILSIRVRKTEHKLSLQAKKAEISS
>Mature_456_residues
MQQTVTYGAKWKQFLTIFTPIVITQLTLFSMTFFDTTMSGNYSNQALAGVAIGSSFWAPVNAAFSGLLMAITPIIAQLIG
AKKEKEVKNTVHNGLYIALLLAFILILINFMVVPMILTHMPVTAEVAHIARHFLNGICIGIPAFFISAILRSFIDSLGLT
RVTMLITLCTVPFNIFLNYCFIFGNFGFPEMGGAGSGYATGITYWLVVLVSVILIQTQTRLRKFDIFKGFTALHFSKIKE
IIGIGVPNGLTILFETSIFSAVTILMGAFGTETIAAHQSANSVCTLLYAFPLSVASTLTILGGYETGAKRLKDAKQYRHI
GMTAAILIGFINGAILFFFRDIIAGFYTNDIELIELIKHFLVYAILFQFADAVLSPVLGALRGYKDVTVTSVVAFISYWL
IGLPVGYGLSFTNLGPFGYWIGLSTGLFIAAFILSIRVRKTEHKLSLQAKKAEISS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=434, Percent_Identity=21.4285714285714, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38261960, Length=229, Percent_Identity=23.1441048034935, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI22907060, Length=416, Percent_Identity=21.3942307692308, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994890, Length=438, Percent_Identity=31.2785388127854, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI226510954, Length=432, Percent_Identity=25, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320545, Length=404, Percent_Identity=23.019801980198, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321821, Length=374, Percent_Identity=22.9946524064171, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49896; Mature: 49896

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]