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The map label for this gene is tktB

Identifier: 116872796

GI number: 116872796

Start: 1366246

End: 1368150

Strand: Direct

Name: tktB

Synonym: lwe1380

Alternate gene names: 116872796

Gene position: 1366246-1368150 (Clockwise)

Preceding gene: 116872795

Following gene: 116872797

Centisome position: 48.55

GC content: 36.9

Gene sequence:

>1905_bases
TTGGATCTTTTAAAAATAAAGGATCCTTCCTTTATGAAACAATTGGATATAAAAGAATTAGAAGCACTTGCTGCGGATAT
TCGCGCTTTTTTAATTACATCTACTTCCAAATCAGGTGGGCATATTGGTCCAAATCTTGGTGTGGTAGAACTAACAATTG
CGCTACACTACACTTTTAATAGTCCAAAAGATAAATTTATTTGGGATGTTGGTCATCAGTCATATGTGCACAAAATCCTA
ACTGGAAGGGCGAATCAATTTGATACATTACGCAAGCATGGTGGATTAGACGGATTTCCAAAAAGAAAAGAATCTATTCA
TGATGTATTTGAAACTGGTCATAGTTCTACTTCTTTATCTGCTGCTTGTGGAATGGTTATTGCGAGAGATATAAAAAAAG
AAGATTTTTATGTTATCCCTATAATAGGTGATGGTGCATTAACTGGCGGAATGGCCTTTGAAGCCTTAAATCATATAGGG
GATATGGGAAAAGATATGATTGTTATTTTAAATGATAATGATATGTCAATTGCACCCAATGTAGGAGCACTTCACAATGT
CCTCGGTAAATTAAGAACATCCGATAAATTTCAACAAACAAAAACGAATATAGATAAATTAATAAGAAAAATTCCTACTG
CTGGTGAAAAATTAGCAGACACGGCTGAAAAAACAAAAGACAGTTTAAAGCATTTACTTGTAAATGGCACTTTTTTTGAA
GAATTAGGTTTTATGTATTTAGGTCCAATAGATGGACATAATTTAGAAGATATCTTAACGAACTTGGAAATTGCCAAGCG
AGCTAGAGGGCCTGTAATCCTTCATGTCGTCACAAAAAAAGGAAAAGGATACCAGCCAGCCGAACTTGACTCTCGTGGCA
CCTGGCATGGTACAGGACCATATAAGGTCGAAACAGGTAGTTTTATTAAGTCGGTCAAGACAGCACCGTCATGGAGTTCA
GTAATTAGTAATGAATTAATGAGACTAGCAACAGCTGATGAGCGTATAGTAGCCATAACTCCTGCGATGCCAGTAGGCTC
CAAATTAGAAAAATTCGCTAAAGCTTTTCCGGAAAGATTTTTTGATGTCGGAATCGCTGAACAACATGCGACAACGATGG
CAGCTGGTTTAGCAACTCAAGGAATGAAGCCTTTTTTAGCTATATATTCTACCTTTTTACAAAGAGCTTATGATCAATTA
GTCCATGATGTTTGTCGACAAAAATTAAATGTCGTAATTGGAATTGATCGTGCTGGTCTTGTTGGAGCTGACGGGGAAAC
ACATCAAGGTATTTTTGATATTTCTTTTCTGAACAGCATTCCAAACATGATTATTACTATGCCAAAAGATGAAGTAGAAG
CTAGACAATTAATGGTCACTGCTTTTGATTATGATGCTGGCCCGTTTGCTATTCGTTATCCGCGTGGAAATGGACTAGGG
GTGGAGTTAACCGAATCTAATACACTAATTCCAATTGGAGAGTGGGAAACAATTATTCAGCCTATTGACGCTGTTATAGT
TACTTTTGGACCAACGATTCAATTAGCCCTGAAAGCAGCGGATCAATTAGAAACAGAAGGGTACCGTGTTGGAGTGATTA
ACGCACGTTTTATCAAACCACTCGATGAAACTTTACTACACCAAATGATTAAGCAAAAAATCCCCATTTTAACAGTAGAA
GAATCATTATTAAAAGGTGGGTTTGGTGCAAGTGTGTTAGAATTTATAGAAACGAACAATTATACCGATGTAGCTATTCA
TCGAATTGGTTTACCGGACGAATTTATCAGCCATGGTTCAGTCCCTGTAATTCTTGAATCGTATGGCATATCGGAAGCTG
GAATTGAATTAAAAATAAAAGAAATGCTCGCACAAAGCGAGAAGTTAAGGGCGAAGAGACTATGA

Upstream 100 bases:

>100_bases
TTTAACTGGAATTATTTGCTATAATAAGAACAATTAATGGAGAAAAAAGACATTGCACGCATTCATGCGAGTGACTCTTT
AGAAAGTGAGTTGTTTTTAT

Downstream 100 bases:

>100_bases
CAATAAAAAAAGAACGTGCAGATATTCTGTTAGTAGAACAAGGACTATTTGAAACAAGAGAAAAAGCGAAACGGGCCATT
ATGGCAGGAATTGTGTATCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MDLLKIKDPSFMKQLDIKELEALAADIRAFLITSTSKSGGHIGPNLGVVELTIALHYTFNSPKDKFIWDVGHQSYVHKIL
TGRANQFDTLRKHGGLDGFPKRKESIHDVFETGHSSTSLSAACGMVIARDIKKEDFYVIPIIGDGALTGGMAFEALNHIG
DMGKDMIVILNDNDMSIAPNVGALHNVLGKLRTSDKFQQTKTNIDKLIRKIPTAGEKLADTAEKTKDSLKHLLVNGTFFE
ELGFMYLGPIDGHNLEDILTNLEIAKRARGPVILHVVTKKGKGYQPAELDSRGTWHGTGPYKVETGSFIKSVKTAPSWSS
VISNELMRLATADERIVAITPAMPVGSKLEKFAKAFPERFFDVGIAEQHATTMAAGLATQGMKPFLAIYSTFLQRAYDQL
VHDVCRQKLNVVIGIDRAGLVGADGETHQGIFDISFLNSIPNMIITMPKDEVEARQLMVTAFDYDAGPFAIRYPRGNGLG
VELTESNTLIPIGEWETIIQPIDAVIVTFGPTIQLALKAADQLETEGYRVGVINARFIKPLDETLLHQMIKQKIPILTVE
ESLLKGGFGASVLEFIETNNYTDVAIHRIGLPDEFISHGSVPVILESYGISEAGIELKIKEMLAQSEKLRAKRL

Sequences:

>Translated_634_residues
MDLLKIKDPSFMKQLDIKELEALAADIRAFLITSTSKSGGHIGPNLGVVELTIALHYTFNSPKDKFIWDVGHQSYVHKIL
TGRANQFDTLRKHGGLDGFPKRKESIHDVFETGHSSTSLSAACGMVIARDIKKEDFYVIPIIGDGALTGGMAFEALNHIG
DMGKDMIVILNDNDMSIAPNVGALHNVLGKLRTSDKFQQTKTNIDKLIRKIPTAGEKLADTAEKTKDSLKHLLVNGTFFE
ELGFMYLGPIDGHNLEDILTNLEIAKRARGPVILHVVTKKGKGYQPAELDSRGTWHGTGPYKVETGSFIKSVKTAPSWSS
VISNELMRLATADERIVAITPAMPVGSKLEKFAKAFPERFFDVGIAEQHATTMAAGLATQGMKPFLAIYSTFLQRAYDQL
VHDVCRQKLNVVIGIDRAGLVGADGETHQGIFDISFLNSIPNMIITMPKDEVEARQLMVTAFDYDAGPFAIRYPRGNGLG
VELTESNTLIPIGEWETIIQPIDAVIVTFGPTIQLALKAADQLETEGYRVGVINARFIKPLDETLLHQMIKQKIPILTVE
ESLLKGGFGASVLEFIETNNYTDVAIHRIGLPDEFISHGSVPVILESYGISEAGIELKIKEMLAQSEKLRAKRL
>Mature_634_residues
MDLLKIKDPSFMKQLDIKELEALAADIRAFLITSTSKSGGHIGPNLGVVELTIALHYTFNSPKDKFIWDVGHQSYVHKIL
TGRANQFDTLRKHGGLDGFPKRKESIHDVFETGHSSTSLSAACGMVIARDIKKEDFYVIPIIGDGALTGGMAFEALNHIG
DMGKDMIVILNDNDMSIAPNVGALHNVLGKLRTSDKFQQTKTNIDKLIRKIPTAGEKLADTAEKTKDSLKHLLVNGTFFE
ELGFMYLGPIDGHNLEDILTNLEIAKRARGPVILHVVTKKGKGYQPAELDSRGTWHGTGPYKVETGSFIKSVKTAPSWSS
VISNELMRLATADERIVAITPAMPVGSKLEKFAKAFPERFFDVGIAEQHATTMAAGLATQGMKPFLAIYSTFLQRAYDQL
VHDVCRQKLNVVIGIDRAGLVGADGETHQGIFDISFLNSIPNMIITMPKDEVEARQLMVTAFDYDAGPFAIRYPRGNGLG
VELTESNTLIPIGEWETIIQPIDAVIVTFGPTIQLALKAADQLETEGYRVGVINARFIKPLDETLLHQMIKQKIPILTVE
ESLLKGGFGASVLEFIETNNYTDVAIHRIGLPDEFISHGSVPVILESYGISEAGIELKIKEMLAQSEKLRAKRL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=679, Percent_Identity=23.2695139911635, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4507521, Length=679, Percent_Identity=23.2695139911635, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI133778974, Length=662, Percent_Identity=23.8670694864048, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637463, Length=306, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637459, Length=306, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637461, Length=306, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=46.3295269168026, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17539652, Length=658, Percent_Identity=23.7082066869301, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666278, Length=630, Percent_Identity=24.4444444444444, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551847, Length=670, Percent_Identity=23.134328358209, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45550715, Length=670, Percent_Identity=23.134328358209, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24645119, Length=627, Percent_Identity=23.1259968102073, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_LISW6 (A0AIG6)

Other databases:

- EMBL:   AM263198
- RefSeq:   YP_849577.1
- ProteinModelPortal:   A0AIG6
- SMR:   A0AIG6
- STRING:   A0AIG6
- GeneID:   4465696
- GenomeReviews:   AM263198_GR
- KEGG:   lwe:lwe1380
- NMPDR:   fig|386043.6.peg.1336
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   A0AIG6
- ProtClustDB:   PRK05444
- BioCyc:   LWEL386043:LWE1380-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69660; Mature: 69660

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLKIKDPSFMKQLDIKELEALAADIRAFLITSTSKSGGHIGPNLGVVELTIALHYTFN
CCCEECCCCHHHHHCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEEEEEEEC
SPKDKFIWDVGHQSYVHKILTGRANQFDTLRKHGGLDGFPKRKESIHDVFETGHSSTSLS
CCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHH
AACGMVIARDIKKEDFYVIPIIGDGALTGGMAFEALNHIGDMGKDMIVILNDNDMSIAPN
HHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEECCC
VGALHNVLGKLRTSDKFQQTKTNIDKLIRKIPTAGEKLADTAEKTKDSLKHLLVNGTFFE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
ELGFMYLGPIDGHNLEDILTNLEIAKRARGPVILHVVTKKGKGYQPAELDSRGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKVETGSFIKSVKTAPSWSSVISNELMRLATADERIVAITPAMPVGSKLEKFAKAFPERF
EEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FDVGIAEQHATTMAAGLATQGMKPFLAIYSTFLQRAYDQLVHDVCRQKLNVVIGIDRAGL
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCE
VGADGETHQGIFDISFLNSIPNMIITMPKDEVEARQLMVTAFDYDAGPFAIRYPRGNGLG
ECCCCCCCCCEEEHHHHHCCCCEEEECCCHHHHHHHEEEEEEECCCCCEEEECCCCCCCE
VELTESNTLIPIGEWETIIQPIDAVIVTFGPTIQLALKAADQLETEGYRVGVINARFIKP
EEEECCCCEEECCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEHHHHCH
LDETLLHQMIKQKIPILTVEESLLKGGFGASVLEFIETNNYTDVAIHRIGLPDEFISHGS
HHHHHHHHHHHHCCCEEEECHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHCCCC
VPVILESYGISEAGIELKIKEMLAQSEKLRAKRL
CEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLLKIKDPSFMKQLDIKELEALAADIRAFLITSTSKSGGHIGPNLGVVELTIALHYTFN
CCCEECCCCHHHHHCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEEEEEEEC
SPKDKFIWDVGHQSYVHKILTGRANQFDTLRKHGGLDGFPKRKESIHDVFETGHSSTSLS
CCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHH
AACGMVIARDIKKEDFYVIPIIGDGALTGGMAFEALNHIGDMGKDMIVILNDNDMSIAPN
HHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEECCC
VGALHNVLGKLRTSDKFQQTKTNIDKLIRKIPTAGEKLADTAEKTKDSLKHLLVNGTFFE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
ELGFMYLGPIDGHNLEDILTNLEIAKRARGPVILHVVTKKGKGYQPAELDSRGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKVETGSFIKSVKTAPSWSSVISNELMRLATADERIVAITPAMPVGSKLEKFAKAFPERF
EEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FDVGIAEQHATTMAAGLATQGMKPFLAIYSTFLQRAYDQLVHDVCRQKLNVVIGIDRAGL
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCE
VGADGETHQGIFDISFLNSIPNMIITMPKDEVEARQLMVTAFDYDAGPFAIRYPRGNGLG
ECCCCCCCCCEEEHHHHHCCCCEEEECCCHHHHHHHEEEEEEECCCCCEEEECCCCCCCE
VELTESNTLIPIGEWETIIQPIDAVIVTFGPTIQLALKAADQLETEGYRVGVINARFIKP
EEEECCCCEEECCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEHHHHCH
LDETLLHQMIKQKIPILTVEESLLKGGFGASVLEFIETNNYTDVAIHRIGLPDEFISHGS
HHHHHHHHHHHHCCCEEEECHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHCCCC
VPVILESYGISEAGIELKIKEMLAQSEKLRAKRL
CEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA