Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 116872794

GI number: 116872794

Start: 1364784

End: 1365665

Strand: Direct

Name: ispA [C]

Synonym: lwe1378

Alternate gene names: 116872794

Gene position: 1364784-1365665 (Clockwise)

Preceding gene: 116872793

Following gene: 116872795

Centisome position: 48.5

GC content: 37.3

Gene sequence:

>882_bases
TTGCAAGATTTGACGCTTTTTCTAGCACACTATAAAAAAGTACTTGATGAGTCGCTTTATAAAGAAATAAAAAAGCGGAA
TATTGAACCGAAATTAAAAGAATCAATGTTATATTCTGTACAAGCTGGTGGAAAAAGAATTCGACCAATGCTCGTTTTTG
CAACACTGCAAGCATTAAATAAGGACCCGATGATTGGTTTGAAAACGGCTACTGCACTTGAGATGATTCATACGTATAGC
TTAATACATGATGATTTACCCGCAATGGATGATGATGATTATCGGCGCGGGAAAAAGACGAACCACAAAGTATTTGGTGA
TGCCACAGCTATTTTAGCAGGAGATGCTTTGTTGACACTTGCTTTTTCCATCGTAGCTGAAGATGAAAACTTATCCTTTG
AAACACGCATTGCTTTAATTAATCAAATTAGCTATAGCAGTGGAGCAGAAGGCATGGTTGGTGGGCAACAAGCAGATATC
GAGGCAGAGAATAAGCAAGTCACATTAGAAGAGTTATCTTCTATCCACGCACGAAAAACAGGTGAATTATTAATTTTTGC
TGTAACATCTGCTGCAAAAATTGCCGAAGCTAACTCTGAGCAAACAAAACGATTACGCATTTTTGCAGAAAATATTGGGG
TTGGATTTCAAATAAGTGATGATATTTTAGATGTAATTGGCGATGAAACAAAAATGGGTAAAAAGACAGGGGTGGATGTT
TTTATGAATAAAAGTACCTATCCCGGATTACTCACGTTAGATGGTGCCAAAAGGGCATTAAACGAGCATGTTTCTATCGC
AAAGTCAGCGCTTTCAGGGCATGATCTTGATGATGAAATTCTATTGAAACTGGCTGATTTAATAGCGCTCAGAGAAAATT
AA

Upstream 100 bases:

>100_bases
AATTATGCCAAGACAAGTTACAAACAGCAGAAAAAAGAATGGCTAAAGTAGTCACGGATACAGGAGAAGAAATTCCTTTT
GAAGCGGATGGTGAATAAAT

Downstream 100 bases:

>100_bases
TTATACTTATCAGGTAATTTCAAAATTTTTTCACATATATAATTCAAATTGATTTGCTTTTCCTAAAATACCGTGTTATA
CTAATGTAAGATTATTTTTG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MQDLTLFLAHYKKVLDESLYKEIKKRNIEPKLKESMLYSVQAGGKRIRPMLVFATLQALNKDPMIGLKTATALEMIHTYS
LIHDDLPAMDDDDYRRGKKTNHKVFGDATAILAGDALLTLAFSIVAEDENLSFETRIALINQISYSSGAEGMVGGQQADI
EAENKQVTLEELSSIHARKTGELLIFAVTSAAKIAEANSEQTKRLRIFAENIGVGFQISDDILDVIGDETKMGKKTGVDV
FMNKSTYPGLLTLDGAKRALNEHVSIAKSALSGHDLDDEILLKLADLIALREN

Sequences:

>Translated_293_residues
MQDLTLFLAHYKKVLDESLYKEIKKRNIEPKLKESMLYSVQAGGKRIRPMLVFATLQALNKDPMIGLKTATALEMIHTYS
LIHDDLPAMDDDDYRRGKKTNHKVFGDATAILAGDALLTLAFSIVAEDENLSFETRIALINQISYSSGAEGMVGGQQADI
EAENKQVTLEELSSIHARKTGELLIFAVTSAAKIAEANSEQTKRLRIFAENIGVGFQISDDILDVIGDETKMGKKTGVDV
FMNKSTYPGLLTLDGAKRALNEHVSIAKSALSGHDLDDEILLKLADLIALREN
>Mature_293_residues
MQDLTLFLAHYKKVLDESLYKEIKKRNIEPKLKESMLYSVQAGGKRIRPMLVFATLQALNKDPMIGLKTATALEMIHTYS
LIHDDLPAMDDDDYRRGKKTNHKVFGDATAILAGDALLTLAFSIVAEDENLSFETRIALINQISYSSGAEGMVGGQQADI
EAENKQVTLEELSSIHARKTGELLIFAVTSAAKIAEANSEQTKRLRIFAENIGVGFQISDDILDVIGDETKMGKKTGVDV
FMNKSTYPGLLTLDGAKRALNEHVSIAKSALSGHDLDDEILLKLADLIALREN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=251, Percent_Identity=30.6772908366534, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786623, Length=270, Percent_Identity=45.9259259259259, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1789578, Length=212, Percent_Identity=32.5471698113208, Blast_Score=101, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17505681, Length=261, Percent_Identity=26.0536398467433, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=240, Percent_Identity=28.75, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32253; Mature: 32253

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00052 RIBOSOMAL_S7 ; PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDLTLFLAHYKKVLDESLYKEIKKRNIEPKLKESMLYSVQAGGKRIRPMLVFATLQALN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
KDPMIGLKTATALEMIHTYSLIHDDLPAMDDDDYRRGKKTNHKVFGDATAILAGDALLTL
CCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEECCHHHHHHHHHHHHH
AFSIVAEDENLSFETRIALINQISYSSGAEGMVGGQQADIEAENKQVTLEELSSIHARKT
HHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCC
GELLIFAVTSAAKIAEANSEQTKRLRIFAENIGVGFQISDDILDVIGDETKMGKKTGVDV
CCEEEEEECCHHHHHHCCCHHHHHHEEEHHHCCCCEEECHHHHHHHCCCHHCCCCCCCEE
FMNKSTYPGLLTLDGAKRALNEHVSIAKSALSGHDLDDEILLKLADLIALREN
EECCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDLTLFLAHYKKVLDESLYKEIKKRNIEPKLKESMLYSVQAGGKRIRPMLVFATLQALN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
KDPMIGLKTATALEMIHTYSLIHDDLPAMDDDDYRRGKKTNHKVFGDATAILAGDALLTL
CCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEECCHHHHHHHHHHHHH
AFSIVAEDENLSFETRIALINQISYSSGAEGMVGGQQADIEAENKQVTLEELSSIHARKT
HHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCC
GELLIFAVTSAAKIAEANSEQTKRLRIFAENIGVGFQISDDILDVIGDETKMGKKTGVDV
CCEEEEEECCHHHHHHCCCHHHHHHEEEHHHCCCCEEECHHHHHHHCCCHHCCCCCCCEE
FMNKSTYPGLLTLDGAKRALNEHVSIAKSALSGHDLDDEILLKLADLIALREN
EECCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]