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The map label for this gene is parC [H]

Identifier: 116872720

GI number: 116872720

Start: 1293494

End: 1295953

Strand: Direct

Name: parC [H]

Synonym: lwe1304

Alternate gene names: 116872720

Gene position: 1293494-1295953 (Clockwise)

Preceding gene: 116872719

Following gene: 116872721

Centisome position: 45.96

GC content: 36.91

Gene sequence:

>2460_bases
TTGAGTAATCCAGAACAACATATCCAAGACTTAGCGCTTGAAGAAGTTATGGGCGACCGTTTTGGTAGGTATAGTAAATA
TATTATTCAAGAACGTGCGCTTCCAGATGTACGAGATGGACTTAAACCTGTTCAACGTCGTATTTTATTTGCAATGAATG
TCGAAGGAAATACAGCTGAAAAAGGTTTCCGTAAATCTGCTAAAACAGTCGGGAATGTAATTGGTAATTATCATCCGCAT
GGTGATTCTTCCGTTTATGAAGCAATGGTACGGATGAGTCAAGACTGGAAAGTTCGTAATATGCTCATTGAGATGCATGG
GAACAATGGTAGTGTAGACGGTGATCCGCCTGCTGCAATGCGTTATACTGAAGCACGACTTTCCCCAATATCCGCTGAAT
TGTTACGTGATATTGAAAAAGAAACAGTCGACTTTATTCCTAACTTTGATGATACTTCTAGTGAACCAACTGTTTTACCA
GCACGTTTTCCTAACCTTTTGGTAAATGGTTCTACAGGTATTTCGGCCGGATATGCAACTGATATTCCGCCACACAATTT
AACTGAAATTATTGAAGCAGTCATTAAACGACTGGATAAGCCGCTTTCAACAACTGAAGATATTATGAAAATTGTCAAAG
GACCTGATTTCCCAACTGGCGGAATTATTCAAGGTATTGACGGAATTCGTAAAGCTTATGAAACTGGAAAAGGCCGTATA
GTTGTTCGTTCCAAAACAGAAATTGAAGATATTCGTGGTGGCAGAAAACAAATTACTATTCATGAAATTCCATATGAAGT
GAATAAAGCTAATTTAGTCAAACGAATGGATGAACTACGTATTGAGAAGAAAATTGAAGGGATTTCAGAAGTACGTGATG
AAACAGATCGTACTGGCCTCCGTATCGCTGTTGAACTAAAAAAAGATGCCAATGCGGAAGGCGTTCTGAATTATCTATTT
AAAAATACAGATTTACAAGTAAGTTATAATTTCAACATGGTAGCCATTCATAATAAACGTCCAGAGTTAATGGGTATTAT
CCCAATGCTTGACGCTTATATTGAACACCAAAAAGAAATTATTACGAAACGTTCAGAATATGACATTCGTAAAGCACGTG
CTCGTCAACATATTTTAGAAGGATTAATTAAGGCGCTTTCTATTCTAGATGAAGTTATTAAGTTAATTCGTGGTTCCAAA
GACAAACGTGACGCTAAATTAAACTTGCAAACAACATATGATTTCAGTGAAAAACAAGCGGAAGCAATTGTTTCCTTACA
ACTTTATCGCTTAACGAATACAGATATTCATGAACTTCAAAGTGAAGCAAAAGAACTAGCGGACCAAATTAGCGTACTTG
AAAAAATCTTGGGTGATGAGTCCGAACTTATAGCTGTTTTAAAATCCGAACTAGCGGACATCAAGAAAAAATATAAAACA
CCTCGCCGGACTGAAGTGCAAGCAGAAATCAGCGAAATCAAAATTGATACTGAAGTACTGGTTGCTAATGAAGATGTGAT
AGTATCTGTGACCAAAGAAGGGTATGTTAAACGTACAAGTCAACGCTCTTATGCAGCGTCAAATGGGGCTGAACTTGCTA
TGAAAGAAGCCGATCATGCCATCTTCATTAAGAAAATGAATTCACTAGATACACTCCTTTTATTTACGAGCAAAGGGAAC
TTCATTTATCGACCTGTCCATGAATTACCAGATATTCGTTGGAAAAATCTTGGGGATCATGTTAGTCATTTGGCTAGTGA
TTTATCTGCAGGTGAAGAAATACGCTCAGCTATTGCTATTCAAACTTTCACGGAAGAAAAACGTTTCCTATTTGTGACTA
AAAATGGTATGACGAAACAATCAGCCATTACGAATTACAAACCACAACGTTATTCCAAATCGATGATGGCTATCAAGTTA
AAAGATAATGATGAACTTTTAAGTGTGAATTTAATTGATGGTACAGAAGATATATTCTTAGCCACTCGTAATGGCTATGG
GCTGCGTTATCCAATTGCTGAAATACCAGAGTCTGGGGCAAGAACAGCAGGTGTAAAAGCAATCAATCTGAAACAAGACG
ATATTGTCATTGGTGGAGTAATACTTGCGCCTAATGACACAAAACACATTTTATTAGCGACTCAGCGTGGTTCATTGAAA
CAAATGAAAGCAAGTGAATTTGAACCAATCTCAAGAGCCAAACGTGGTTTATTAATGTTACGAGAACTTAAAAATAATCC
ACATCGCTTTATCGGCATGACATTAGCTGATAATAATGATCATTTATTTATTGAAACAAACACTGATCAAATTGTTGAGA
TAGATGTAGCTAATCTACGTGTGACGGATCGTTATTCTAATGGTTCGTTTGTATTAGATGAAACGATGGAAGGAGAACCG
AAATCCATTTGGTTAGATATTCCAGAAATAAAAGACACGAGTGACGCGAAAGACGAGTAA

Upstream 100 bases:

>100_bases
CAAGACGTCAGTGGATTGAAAAGCATGTCGAGTTTTCTATGGAAGATAACCAAAATATTTTAGAAAATGAAAACATGATG
GTTGAGGAGGCGAAAGACAT

Downstream 100 bases:

>100_bases
TGAGAAAGAATCTTTGCATTGAAAATATGCAAGGATTCTTTTTTTTGATATAATGACTAGGAATAAAAGGAGGGGCACGC
ATGACAGAAAAAATGAATGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPH
GDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLP
ARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDKPLSTTEDIMKIVKGPDFPTGGIIQGIDGIRKAYETGKGRI
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLF
KNTDLQVSYNFNMVAIHNKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSK
DKRDAKLNLQTTYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKELADQISVLEKILGDESELIAVLKSELADIKKKYKT
PRRTEVQAEISEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAIFIKKMNSLDTLLLFTSKGN
FIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQTFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKL
KDNDELLSVNLIDGTEDIFLATRNGYGLRYPIAEIPESGARTAGVKAINLKQDDIVIGGVILAPNDTKHILLATQRGSLK
QMKASEFEPISRAKRGLLMLRELKNNPHRFIGMTLADNNDHLFIETNTDQIVEIDVANLRVTDRYSNGSFVLDETMEGEP
KSIWLDIPEIKDTSDAKDE

Sequences:

>Translated_819_residues
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPH
GDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLP
ARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDKPLSTTEDIMKIVKGPDFPTGGIIQGIDGIRKAYETGKGRI
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLF
KNTDLQVSYNFNMVAIHNKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSK
DKRDAKLNLQTTYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKELADQISVLEKILGDESELIAVLKSELADIKKKYKT
PRRTEVQAEISEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAIFIKKMNSLDTLLLFTSKGN
FIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQTFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKL
KDNDELLSVNLIDGTEDIFLATRNGYGLRYPIAEIPESGARTAGVKAINLKQDDIVIGGVILAPNDTKHILLATQRGSLK
QMKASEFEPISRAKRGLLMLRELKNNPHRFIGMTLADNNDHLFIETNTDQIVEIDVANLRVTDRYSNGSFVLDETMEGEP
KSIWLDIPEIKDTSDAKDE
>Mature_818_residues
SNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPA
RFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDKPLSTTEDIMKIVKGPDFPTGGIIQGIDGIRKAYETGKGRIV
VRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLFK
NTDLQVSYNFNMVAIHNKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKD
KRDAKLNLQTTYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKELADQISVLEKILGDESELIAVLKSELADIKKKYKTP
RRTEVQAEISEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAIFIKKMNSLDTLLLFTSKGNF
IYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQTFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLK
DNDELLSVNLIDGTEDIFLATRNGYGLRYPIAEIPESGARTAGVKAINLKQDDIVIGGVILAPNDTKHILLATQRGSLKQ
MKASEFEPISRAKRGLLMLRELKNNPHRFIGMTLADNNDHLFIETNTDQIVEIDVANLRVTDRYSNGSFVLDETMEGEPK
SIWLDIPEIKDTSDAKDE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=29.5454545454545, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788562, Length=842, Percent_Identity=38.8361045130641, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1789396, Length=748, Percent_Identity=33.1550802139037, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=170, Percent_Identity=30.5882352941176, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=231, Percent_Identity=29.4372294372294, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=167, Percent_Identity=28.1437125748503, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136538, Length=175, Percent_Identity=29.7142857142857, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92315; Mature: 92184

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCHH
KGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYAT
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCC
DIPPHNLTEIIEAVIKRLDKPLSTTEDIMKIVKGPDFPTGGIIQGIDGIRKAYETGKGRI
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGL
EEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAIHNKRPELMGIIPMLDAYIEHQKEI
EEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTTYDFSEKQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHH
EAIVSLQLYRLTNTDIHELQSEAKELADQISVLEKILGDESELIAVLKSELADIKKKYKT
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRRTEVQAEISEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHA
CCCHHHHHHHHHEEECEEEEEECCCEEEEEECCCCHHHCCCCHHCCCCCCHHHHHHCCCE
IFIKKMNSLDTLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAI
EEEEECCCCCEEEEEECCCCEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QTFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKDNDELLSVNLIDGTEDIFL
HEECCCCEEEEEECCCCCHHHHHCCCCCHHHCCCEEEEEEECCCCEEEEEEECCCCEEEE
ATRNGYGLRYPIAEIPESGARTAGVKAINLKQDDIVIGGVILAPNDTKHILLATQRGSLK
EECCCCCEECCHHHCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCHH
QMKASEFEPISRAKRGLLMLRELKNNPHRFIGMTLADNNDHLFIETNTDQIVEIDVANLR
HHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
VTDRYSNGSFVLDETMEGEPKSIWLDIPEIKDTSDAKDE
EEEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCHH
KGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYAT
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCC
DIPPHNLTEIIEAVIKRLDKPLSTTEDIMKIVKGPDFPTGGIIQGIDGIRKAYETGKGRI
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGL
EEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAIHNKRPELMGIIPMLDAYIEHQKEI
EEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTTYDFSEKQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHH
EAIVSLQLYRLTNTDIHELQSEAKELADQISVLEKILGDESELIAVLKSELADIKKKYKT
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRRTEVQAEISEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHA
CCCHHHHHHHHHEEECEEEEEECCCEEEEEECCCCHHHCCCCHHCCCCCCHHHHHHCCCE
IFIKKMNSLDTLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAI
EEEEECCCCCEEEEEECCCCEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QTFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKDNDELLSVNLIDGTEDIFL
HEECCCCEEEEEECCCCCHHHHHCCCCCHHHCCCEEEEEEECCCCEEEEEEECCCCEEEE
ATRNGYGLRYPIAEIPESGARTAGVKAINLKQDDIVIGGVILAPNDTKHILLATQRGSLK
EECCCCCEECCHHHCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCHH
QMKASEFEPISRAKRGLLMLRELKNNPHRFIGMTLADNNDHLFIETNTDQIVEIDVANLR
HHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
VTDRYSNGSFVLDETMEGEPKSIWLDIPEIKDTSDAKDE
EEEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]