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The map label for this gene is typA [H]

Identifier: 116872463

GI number: 116872463

Start: 1059277

End: 1061115

Strand: Direct

Name: typA [H]

Synonym: lwe1045

Alternate gene names: 116872463

Gene position: 1059277-1061115 (Clockwise)

Preceding gene: 116872462

Following gene: 116872464

Centisome position: 37.64

GC content: 38.17

Gene sequence:

>1839_bases
TTGAATTTAAGAAATGATATTCGTAATGTAGCAATTATTGCCCACGTTGACCATGGTAAAACGACATTAGTAGACCAATT
ACTGCGCCAATCAGGTACTTTCCGCGACAATGAAACAGTTGCTGAACGTGCGATGGACAACAATGATTTAGAAAGAGAAC
GCGGTATTACAATTTTAGCGAAAAATACAGCGATTAAGTATGAAGATACACGCGTAAACATCATGGATACACCTGGACAC
GCCGATTTCGGTGGAGAAGTAGAACGTATCATGAAAATGGTTGATGGTGTTCTTTTAGTAGTGGACGCGTATGAAGGTAC
AATGCCTCAAACACGTTTTGTACTAAAAAAAGCACTAGAACAAAACTTGACACCAATTGTTGTAGTTAACAAAATTGACC
GTGACTTTGCCCGTCCAGAAGAAGTTGTTGATGAAGTATTAGAATTATTCATCGAACTAGGTGCAAATGATGATCAATTA
GAATTCCCAGTTGTTTATGCTTCTGCTATCAACGGAACTTCAAGTTATGATTCCGATCCAGCAGAACAAAAAGAAACAAT
GAAACCTCTTTTAGATACTATTATCAATCATATTCCAGCTCCAGTTGACAATAGCGACGAACCATTACAATTCCAAGTGT
CTTTACTTGATTATAATGATTATGTTGGTCGTATTGGTATTGGCCGTATTTTCCGCGGAACAATGCACGTAGGACAAACG
GTTGCTTTGATTAAACTTGATGGTACAGTGAAACAATTCCGTGTAACAAAAATGTTTGGTTTCTTCGGACTAAAACGCGA
TGAAATTAAAGAAGCAAAAGCTGGTGATTTAGTAGCACTTGCTGGAATGGAAGATATCTTCGTTGGCGAAACGGTTACAC
CATTTGACCATCAAGAAGCACTTCCGCTTTTACGTATTGATGAACCAACACTACAAATGACTTTTGTAACTAATAACAGT
CCTTTCGCTGGTCGCGAAGGTAAACACGTCACAAGCCGTAAAATTGAAGAACGCTTACTAGCTGAACTTCAAACGGATGT
ATCGCTTCGTGTGGATCCAACAGCTTCCCCAGACGCTTGGGTAGTATCAGGTCGTGGAGAGCTTCATTTATCTATTTTAA
TTGAAACTATGCGTCGTGAAGGTTATGAACTACAAGTTTCTAAACCAGAAGTAATTATCCGTGAAATTGATGGTGTGAAA
TGCGAACCAGTAGAAGACGTTCAAATCGATACGCCAGAAGAATTTATGGGATCAGTTATTGAATCAATTAGCCAACGTAA
AGGTGAAATGAAAAATATGATTAACGATGGTAACGGCCAAGTTCGTCTACAATTCATCGTACCAGCTCGTGGATTAATTG
GTTATACAACTGATTTCCTTTCCATGACACGTGGTTATGGTATTATCAACCATACATTTGATAGCTACCAACCAATCCAA
AAAGGACGTGTTGGTGGACGTAGCCGTGGTGTTCTTGTATCTATGGAAACTGGTAAATCTACTACTTACGGAACAATGCA
AGTAGAAGATCGTGGTACTATCTTTATTGAACCAGGAACTGATATTTATGAAGGTATGATTGTTGGAGAAAACAACCGTG
AAGGCGATATCGCAGTTAATATTGTTAAAGCGAAACAAATGACTAACATTCGTTCAGCTAACAAAGACCAAACTAACGTT
ATCAAAAAACCTCGCCACCTTTCATTAGAAGAATCATTAGAATTCCTAAACGAAGATGAGTACTGTGAAGTAACACCACA
ATCCATTCGTCTACGTAAAAAAATTCTAAACAAAAACGAACGTGAAAAAGCAGCAAAACGTTCAAAAACTGCTGAATAA

Upstream 100 bases:

>100_bases
ACGAGACGATAGCGACGGAGGAAAATAAATCTATTTTCCTCTTTCTTTTGGCTAATCTTCACGATAAATGTTTGGATTTT
TAATTTAGGAGGAAACAAGA

Downstream 100 bases:

>100_bases
TTAGCATGCTAAAAAGCCAAGTTATTTTAGAGTGGATTTGTTCTACTACTTAAAATGACTTGGCTTTTTTATGCATAAAA
GTATGAGAAAAGGGAATAAA

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MNLRNDIRNVAIIAHVDHGKTTLVDQLLRQSGTFRDNETVAERAMDNNDLERERGITILAKNTAIKYEDTRVNIMDTPGH
ADFGGEVERIMKMVDGVLLVVDAYEGTMPQTRFVLKKALEQNLTPIVVVNKIDRDFARPEEVVDEVLELFIELGANDDQL
EFPVVYASAINGTSSYDSDPAEQKETMKPLLDTIINHIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRIFRGTMHVGQT
VALIKLDGTVKQFRVTKMFGFFGLKRDEIKEAKAGDLVALAGMEDIFVGETVTPFDHQEALPLLRIDEPTLQMTFVTNNS
PFAGREGKHVTSRKIEERLLAELQTDVSLRVDPTASPDAWVVSGRGELHLSILIETMRREGYELQVSKPEVIIREIDGVK
CEPVEDVQIDTPEEFMGSVIESISQRKGEMKNMINDGNGQVRLQFIVPARGLIGYTTDFLSMTRGYGIINHTFDSYQPIQ
KGRVGGRSRGVLVSMETGKSTTYGTMQVEDRGTIFIEPGTDIYEGMIVGENNREGDIAVNIVKAKQMTNIRSANKDQTNV
IKKPRHLSLEESLEFLNEDEYCEVTPQSIRLRKKILNKNEREKAAKRSKTAE

Sequences:

>Translated_612_residues
MNLRNDIRNVAIIAHVDHGKTTLVDQLLRQSGTFRDNETVAERAMDNNDLERERGITILAKNTAIKYEDTRVNIMDTPGH
ADFGGEVERIMKMVDGVLLVVDAYEGTMPQTRFVLKKALEQNLTPIVVVNKIDRDFARPEEVVDEVLELFIELGANDDQL
EFPVVYASAINGTSSYDSDPAEQKETMKPLLDTIINHIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRIFRGTMHVGQT
VALIKLDGTVKQFRVTKMFGFFGLKRDEIKEAKAGDLVALAGMEDIFVGETVTPFDHQEALPLLRIDEPTLQMTFVTNNS
PFAGREGKHVTSRKIEERLLAELQTDVSLRVDPTASPDAWVVSGRGELHLSILIETMRREGYELQVSKPEVIIREIDGVK
CEPVEDVQIDTPEEFMGSVIESISQRKGEMKNMINDGNGQVRLQFIVPARGLIGYTTDFLSMTRGYGIINHTFDSYQPIQ
KGRVGGRSRGVLVSMETGKSTTYGTMQVEDRGTIFIEPGTDIYEGMIVGENNREGDIAVNIVKAKQMTNIRSANKDQTNV
IKKPRHLSLEESLEFLNEDEYCEVTPQSIRLRKKILNKNEREKAAKRSKTAE
>Mature_612_residues
MNLRNDIRNVAIIAHVDHGKTTLVDQLLRQSGTFRDNETVAERAMDNNDLERERGITILAKNTAIKYEDTRVNIMDTPGH
ADFGGEVERIMKMVDGVLLVVDAYEGTMPQTRFVLKKALEQNLTPIVVVNKIDRDFARPEEVVDEVLELFIELGANDDQL
EFPVVYASAINGTSSYDSDPAEQKETMKPLLDTIINHIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRIFRGTMHVGQT
VALIKLDGTVKQFRVTKMFGFFGLKRDEIKEAKAGDLVALAGMEDIFVGETVTPFDHQEALPLLRIDEPTLQMTFVTNNS
PFAGREGKHVTSRKIEERLLAELQTDVSLRVDPTASPDAWVVSGRGELHLSILIETMRREGYELQVSKPEVIIREIDGVK
CEPVEDVQIDTPEEFMGSVIESISQRKGEMKNMINDGNGQVRLQFIVPARGLIGYTTDFLSMTRGYGIINHTFDSYQPIQ
KGRVGGRSRGVLVSMETGKSTTYGTMQVEDRGTIFIEPGTDIYEGMIVGENNREGDIAVNIVKAKQMTNIRSANKDQTNV
IKKPRHLSLEESLEFLNEDEYCEVTPQSIRLRKKILNKNEREKAAKRSKTAE

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=512, Percent_Identity=28.515625, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=42.8571428571429, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=35.3333333333333, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=37.9310344827586, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI25306283, Length=168, Percent_Identity=36.9047619047619, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI19923640, Length=168, Percent_Identity=36.9047619047619, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI25306287, Length=168, Percent_Identity=36.9047619047619, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI34147630, Length=280, Percent_Identity=32.1428571428571, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI217272894, Length=189, Percent_Identity=32.8042328042328, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI217272892, Length=189, Percent_Identity=32.8042328042328, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.7829457364341, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=53.2338308457711, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=519, Percent_Identity=29.8651252408478, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789738, Length=166, Percent_Identity=39.1566265060241, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=34.4827586206897, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789737, Length=276, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790412, Length=276, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557151, Length=524, Percent_Identity=26.1450381679389, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556745, Length=464, Percent_Identity=24.3534482758621, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=171, Percent_Identity=37.4269005847953, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=180, Percent_Identity=32.7777777777778, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=37.5, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=37.5, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=140, Percent_Identity=36.4285714285714, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=306, Percent_Identity=28.7581699346405, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25141371, Length=274, Percent_Identity=27.3722627737226, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994658, Length=142, Percent_Identity=36.6197183098592, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=521, Percent_Identity=28.7907869481766, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324707, Length=210, Percent_Identity=34.2857142857143, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=210, Percent_Identity=34.2857142857143, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324761, Length=271, Percent_Identity=30.9963099630996, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323098, Length=177, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=149, Percent_Identity=38.255033557047, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=34.8993288590604, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI78706572, Length=513, Percent_Identity=26.3157894736842, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=40.7142857142857, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357743, Length=189, Percent_Identity=37.037037037037, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281363316, Length=273, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17864358, Length=273, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24582462, Length=171, Percent_Identity=35.672514619883, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585711, Length=172, Percent_Identity=34.8837209302326, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585713, Length=172, Percent_Identity=34.8837209302326, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585709, Length=172, Percent_Identity=34.8837209302326, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221458488, Length=162, Percent_Identity=37.6543209876543, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19921738, Length=232, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28572034, Length=166, Percent_Identity=34.3373493975904, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922690, Length=289, Percent_Identity=27.3356401384083, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68695; Mature: 68695

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRNDIRNVAIIAHVDHGKTTLVDQLLRQSGTFRDNETVAERAMDNNDLERERGITILA
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEE
KNTAIKYEDTRVNIMDTPGHADFGGEVERIMKMVDGVLLVVDAYEGTMPQTRFVLKKALE
ECCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QNLTPIVVVNKIDRDFARPEEVVDEVLELFIELGANDDQLEFPVVYASAINGTSSYDSDP
CCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCC
AEQKETMKPLLDTIINHIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRIFRGTMHVGQT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCE
VALIKLDGTVKQFRVTKMFGFFGLKRDEIKEAKAGDLVALAGMEDIFVGETVTPFDHQEA
EEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCEEECCCCCCCCCHHC
LPLLRIDEPTLQMTFVTNNSPFAGREGKHVTSRKIEERLLAELQTDVSLRVDPTASPDAW
CCEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
VVSGRGELHLSILIETMRREGYELQVSKPEVIIREIDGVKCEPVEDVQIDTPEEFMGSVI
EEECCCCEEHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
ESISQRKGEMKNMINDGNGQVRLQFIVPARGLIGYTTDFLSMTRGYGIINHTFDSYQPIQ
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHH
KGRVGGRSRGVLVSMETGKSTTYGTMQVEDRGTIFIEPGTDIYEGMIVGENNREGDIAVN
HCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEECCCCCHHCCEEEECCCCCCCEEEE
IVKAKQMTNIRSANKDQTNVIKKPRHLSLEESLEFLNEDEYCEVTPQSIRLRKKILNKNE
EEEHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCH
REKAAKRSKTAE
HHHHHHHCCCCC
>Mature Secondary Structure
MNLRNDIRNVAIIAHVDHGKTTLVDQLLRQSGTFRDNETVAERAMDNNDLERERGITILA
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEE
KNTAIKYEDTRVNIMDTPGHADFGGEVERIMKMVDGVLLVVDAYEGTMPQTRFVLKKALE
ECCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QNLTPIVVVNKIDRDFARPEEVVDEVLELFIELGANDDQLEFPVVYASAINGTSSYDSDP
CCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCC
AEQKETMKPLLDTIINHIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRIFRGTMHVGQT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCE
VALIKLDGTVKQFRVTKMFGFFGLKRDEIKEAKAGDLVALAGMEDIFVGETVTPFDHQEA
EEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCEEECCCCCCCCCHHC
LPLLRIDEPTLQMTFVTNNSPFAGREGKHVTSRKIEERLLAELQTDVSLRVDPTASPDAW
CCEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
VVSGRGELHLSILIETMRREGYELQVSKPEVIIREIDGVKCEPVEDVQIDTPEEFMGSVI
EEECCCCEEHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
ESISQRKGEMKNMINDGNGQVRLQFIVPARGLIGYTTDFLSMTRGYGIINHTFDSYQPIQ
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHH
KGRVGGRSRGVLVSMETGKSTTYGTMQVEDRGTIFIEPGTDIYEGMIVGENNREGDIAVN
HCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEECCCCCHHCCEEEECCCCCCCEEEE
IVKAKQMTNIRSANKDQTNVIKKPRHLSLEESLEFLNEDEYCEVTPQSIRLRKKILNKNE
EEEHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCH
REKAAKRSKTAE
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]