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The map label for this gene is zosA [H]

Identifier: 116872028

GI number: 116872028

Start: 644545

End: 646422

Strand: Direct

Name: zosA [H]

Synonym: lwe0608

Alternate gene names: 116872028

Gene position: 644545-646422 (Clockwise)

Preceding gene: 116872027

Following gene: 116872029

Centisome position: 22.9

GC content: 38.76

Gene sequence:

>1878_bases
ATGAAAGAATGGATGAAACGGAATTGGCAATTTGTAACGACTGGTATTAGTGGGATTTTAATTATTGTAGGGTGGTTAGT
CGGCAATGAAGTCGGTGATTTTTGGACTGCAGTAATTTTTCTGAGTGCGTTTGTTATCGGTGGTTTTGAACAAGCCAAAG
AAGGAATTCAAGCAACTATTAAAACGAAAAAGTTAAATGTAGAACTATTGATGATTTTAGCGGCTACAGGTGCTTCAATC
ATCGGTTATTGGTTTGAAGGTGCCATACTAATCTTTATTTTTTCCGTTAGTGGGGCTTTAGAGACGTATACAACAAATAA
AAGTAAACGCGAAATTACGAAATTGATGGCGTTTCAACCAGAGCGAGCATTTCTTTTACTACCAAATGGAGATTTAAAAG
AAATTGCTGCAAAAGATTTACAATTGGATGATATGGTATTAGTTCGACCCGGAGAAAGTGTGCCAATAGATGGGGTTATT
GTTCGTGGTTCGACAACTTTAAACGAAGCGGCAATTAATGGCGAATCAGTGCCTGCCATGAAATCTGCTGGTTCGGAAGT
GTTTGGTGGAACAGTCAATGTAAGTAGTGCTATTACGGTTAAAGTAACTCAAACTTTCGATAATACGATTTTCAGTAAGA
TTATTCGGTTAGTAGAAACAGCTCAAAGCGAACCTTCCAAAACAGCGCGTTTTATTGAACGGTTTGAAGATGCTTATGTC
AAAGCAGTGTTGTTGTTTGTTTTAGTAATGATGTTTTTACCACATTTTGCGCTAGGATGGTCTTGGAATGAGACTTTTTA
TCGGGCGATGGTTTTATTAACGGTTGCTTCTCCGTGTGCATTAGTGGCATCAGTGACTCCTGCGACATTAGCGGCAATTT
CTAATGGTGCACGCCATGGTATTTTATTTAAAGGCGGTGTACACTTAGAAAATTTGCGTGGTATAAAGGCGATCGCATTT
GATAAAACAGGGACTCTAACAAATGGAACTCCAGTTTTAACAGATCGATTGTTTGCAGAAAATGTTGATAAACAGGAAAT
AATAAATATGGTTGTGGCATTAGAACGGCAATCTTTACATCCATTGGCTGCGGCAATTACACAAGATTTGGATGCAGAAG
TAACGAAAAATATAACAGAAATAGAAATAACAGACGTCCCTGGTTGGGGAGTGCAAGCGGATTATAAAGGAGAGATATGG
CAAGTTGGTAAAGCTGGTTTTGTTGGAACAGAGAGCGCTAGAGAGTTTTTGAGTGGTGCCTTTGAGAAACTTGCTAGTGA
AGGGAAAACCGTTGTCTATGTTGCTAAATCGGGTGTTGTATTAGCGATGTTTGCACTTAAAGATACCTGCAGACCTGAAG
CGATGCGCACAATTAAAGCTCTTCAAGCAAAAGGAATTAAAACTATTATGGTAACGGGTGATAATGAACAAACTGGTGCA
GCAATACAAGCCGAATTAGGCATGGATCAAGTAGTTTCTGGATGTTTGCCTGAGAAAAAAGTAGATGTGATAAAAGAATT
ATCGGTATCATATGGAAGTGTAGCGATGGTTGGTGATGGAATTAATGATGCACCCGCTCTTGCGCATGCGGCGGTTGGTA
TTGCCATGGGAAAAGGGACGGATATCGCAATGGAAACAGCAGATGTCGTCTTAATGAAAAATGATTTAGAAAAAATTCCA
TATGCCTTCGCACTTTCCAAACGACTTTACTGGATTAGCTGGCAAAATATTTGTTTTGCAATAGCAGTAATATTGGTTCT
AATAACGGCTAATGTCTTCCAACTGATTAATTTGCCATTTGGGGTAGTTGGTCATGAAGGAAGTACCATACTAGTCATTC
TAAATGGATTAAGATTGCTTAAATCTAATCAAAGGTAG

Upstream 100 bases:

>100_bases
ATAATAATTATTGTTTAATCTGTTTTTCGCATTTGCGAGAGCAGATTTTTGTGTTTTTTAGAGTAATGGGAATCATTATC
ATTTGGAGAGGATGAGTAGG

Downstream 100 bases:

>100_bases
TGATTTATTTGACTGTTCATCTATTCCTAGTCTAAGATAGATGGGCAGTTTCTTTTTGAAAAAAGAGGATATTACCTAAA
AAGATTGGAGATAAGTGCAT

Product: heavy metal-translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MKEWMKRNWQFVTTGISGILIIVGWLVGNEVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFLLLPNGDLKEIAAKDLQLDDMVLVRPGESVPIDGVI
VRGSTTLNEAAINGESVPAMKSAGSEVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVETAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGIKAIAF
DKTGTLTNGTPVLTDRLFAENVDKQEIINMVVALERQSLHPLAAAITQDLDAEVTKNITEIEITDVPGWGVQADYKGEIW
QVGKAGFVGTESAREFLSGAFEKLASEGKTVVYVAKSGVVLAMFALKDTCRPEAMRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDQVVSGCLPEKKVDVIKELSVSYGSVAMVGDGINDAPALAHAAVGIAMGKGTDIAMETADVVLMKNDLEKIP
YAFALSKRLYWISWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLKSNQR

Sequences:

>Translated_625_residues
MKEWMKRNWQFVTTGISGILIIVGWLVGNEVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFLLLPNGDLKEIAAKDLQLDDMVLVRPGESVPIDGVI
VRGSTTLNEAAINGESVPAMKSAGSEVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVETAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGIKAIAF
DKTGTLTNGTPVLTDRLFAENVDKQEIINMVVALERQSLHPLAAAITQDLDAEVTKNITEIEITDVPGWGVQADYKGEIW
QVGKAGFVGTESAREFLSGAFEKLASEGKTVVYVAKSGVVLAMFALKDTCRPEAMRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDQVVSGCLPEKKVDVIKELSVSYGSVAMVGDGINDAPALAHAAVGIAMGKGTDIAMETADVVLMKNDLEKIP
YAFALSKRLYWISWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLKSNQR
>Mature_625_residues
MKEWMKRNWQFVTTGISGILIIVGWLVGNEVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFLLLPNGDLKEIAAKDLQLDDMVLVRPGESVPIDGVI
VRGSTTLNEAAINGESVPAMKSAGSEVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVETAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGIKAIAF
DKTGTLTNGTPVLTDRLFAENVDKQEIINMVVALERQSLHPLAAAITQDLDAEVTKNITEIEITDVPGWGVQADYKGEIW
QVGKAGFVGTESAREFLSGAFEKLASEGKTVVYVAKSGVVLAMFALKDTCRPEAMRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDQVVSGCLPEKKVDVIKELSVSYGSVAMVGDGINDAPALAHAAVGIAMGKGTDIAMETADVVLMKNDLEKIP
YAFALSKRLYWISWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLKSNQR

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=635, Percent_Identity=28.8188976377953, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI115529486, Length=657, Percent_Identity=29.6803652968037, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI55743073, Length=549, Percent_Identity=30.2367941712204, Blast_Score=229, Evalue=9e-60,
Organism=Homo sapiens, GI48762687, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI48762691, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI48762685, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI48762689, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI118498343, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI4502285, Length=179, Percent_Identity=30.1675977653631, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI209413709, Length=179, Percent_Identity=30.1675977653631, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI24638454, Length=179, Percent_Identity=30.1675977653631, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4502271, Length=285, Percent_Identity=25.6140350877193, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI22748667, Length=255, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI237681111, Length=255, Percent_Identity=25.0980392156863, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI21361181, Length=255, Percent_Identity=25.0980392156863, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1789879, Length=583, Percent_Identity=34.3053173241852, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1786691, Length=551, Percent_Identity=31.2159709618875, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1786914, Length=479, Percent_Identity=26.9311064718163, Blast_Score=139, Evalue=7e-34,
Organism=Escherichia coli, GI2367363, Length=520, Percent_Identity=24.0384615384615, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17556548, Length=290, Percent_Identity=31.3793103448276, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71997262, Length=225, Percent_Identity=27.1111111111111, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997275, Length=195, Percent_Identity=28.7179487179487, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997269, Length=164, Percent_Identity=31.7073170731707, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559224, Length=285, Percent_Identity=23.1578947368421, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=490, Percent_Identity=31.2244897959184, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6319772, Length=589, Percent_Identity=25.4668930390492, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325221, Length=595, Percent_Identity=24.0336134453782, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321430, Length=594, Percent_Identity=22.7272727272727, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321271, Length=190, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221329854, Length=326, Percent_Identity=29.4478527607362, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281366617, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668704, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668708, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161085803, Length=190, Percent_Identity=31.5789473684211, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668696, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 67580; Mature: 67580

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEWMKRNWQFVTTGISGILIIVGWLVGNEVGDFWTAVIFLSAFVIGGFEQAKEGIQATI
CCCHHHCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
KTKKLNVELLMILAATGASIIGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQP
EEEECCCEEEEEEHHCCCHHHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHHHHCCC
ERAFLLLPNGDLKEIAAKDLQLDDMVLVRPGESVPIDGVIVRGSTTLNEAAINGESVPAM
CCEEEEECCCCHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHCCCCCCCHH
KSAGSEVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVETAQSEPSKTARFIERFEDAYV
HHCCCHHCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCCCC
ILFKGGVHLENLRGIKAIAFDKTGTLTNGTPVLTDRLFAENVDKQEIINMVVALERQSLH
EEEECCCCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PLAAAITQDLDAEVTKNITEIEITDVPGWGVQADYKGEIWQVGKAGFVGTESAREFLSGA
HHHHHHHHCCCHHHHCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHH
FEKLASEGKTVVYVAKSGVVLAMFALKDTCRPEAMRTIKALQAKGIKTIMVTGDNEQTGA
HHHHHCCCCEEEEEECCCEEEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AIQAELGMDQVVSGCLPEKKVDVIKELSVSYGSVAMVGDGINDAPALAHAAVGIAMGKGT
EEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHEEECCCC
DIAMETADVVLMKNDLEKIPYAFALSKRLYWISWQNICFAIAVILVLITANVFQLINLPF
CEEEECCCEEEEECCHHHCCHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVVGHEGSTILVILNGLRLLKSNQR
EEECCCCCEEEEEEHHHHHHCCCCC
>Mature Secondary Structure
MKEWMKRNWQFVTTGISGILIIVGWLVGNEVGDFWTAVIFLSAFVIGGFEQAKEGIQATI
CCCHHHCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
KTKKLNVELLMILAATGASIIGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQP
EEEECCCEEEEEEHHCCCHHHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHHHHCCC
ERAFLLLPNGDLKEIAAKDLQLDDMVLVRPGESVPIDGVIVRGSTTLNEAAINGESVPAM
CCEEEEECCCCHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHCCCCCCCHH
KSAGSEVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVETAQSEPSKTARFIERFEDAYV
HHCCCHHCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCCCC
ILFKGGVHLENLRGIKAIAFDKTGTLTNGTPVLTDRLFAENVDKQEIINMVVALERQSLH
EEEECCCCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PLAAAITQDLDAEVTKNITEIEITDVPGWGVQADYKGEIWQVGKAGFVGTESAREFLSGA
HHHHHHHHCCCHHHHCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHH
FEKLASEGKTVVYVAKSGVVLAMFALKDTCRPEAMRTIKALQAKGIKTIMVTGDNEQTGA
HHHHHCCCCEEEEEECCCEEEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AIQAELGMDQVVSGCLPEKKVDVIKELSVSYGSVAMVGDGINDAPALAHAAVGIAMGKGT
EEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHEEECCCC
DIAMETADVVLMKNDLEKIPYAFALSKRLYWISWQNICFAIAVILVLITANVFQLINLPF
CEEEECCCEEEEECCHHHCCHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVVGHEGSTILVILNGLRLLKSNQR
EEECCCCCEEEEEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]