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The map label for this gene is fruA [H]

Identifier: 116871808

GI number: 116871808

Start: 399230

End: 400336

Strand: Direct

Name: fruA [H]

Synonym: lwe0388

Alternate gene names: 116871808

Gene position: 399230-400336 (Clockwise)

Preceding gene: 116871807

Following gene: 116871809

Centisome position: 14.19

GC content: 43.72

Gene sequence:

>1107_bases
ATGTTTAAGAAAATTGGGAGTGAACTAAAAAAACATGTTTTAACAGGTATTTCATATATGATTCCGCTCGTTATCGCGGG
TGCCGTAATTATGGCGATTGCTCGAGTTGGCGGTTCGTTTTTCGGAATTACAGATATTTGGGACGCGAAATATGCAGACA
GTGCGAATAGCTTCATTTCGTTACTACACAGTTTAGATGGTTTTGGTGGCTTGGCGCTTGGAATGATGTTCCCGGTTATT
GCCGCATTTATCGGGTATTCCATTGCGGACAAATTAGCACTAGCACCTGGTCTTGTTGGTGGTTTGCTGGCACGTGATAT
CGGTGCCGGTTTCCTCGGGGCTCTCGCAGCTGGTCTAATCGCTGGTTACACATGTCTTTTAATTAAAAAATATGTGAAAT
TGCCTAAAGCGGCGGCTTCTATCGTACCAGTATTTTTAGTTCCAGTTTTTGGGACACTTATTACAGTTCTTATAATTAAT
TATGTCGTTGGTATTCCTTTTGCAGATTTAAATACTGCCCTTGAAAATTGGCTTAATGGTATGTCTGGATCGAACCAAAT
TTTGATGGCTGCTATTATTGGCGCAATGGTTGGTTTTGACTTAGGCGGACCTGTTAATAAAGCAGCTGTAACAACGGCGA
TGGCACTTTTAACAAGCGGAATCTATGCACCCAATACAGCAGCGCAAGTAGCGATTATTATTCCGCCACTTGGTCTTGGT
TTAGCTACTTTAATCGCAAAACGCAAATATAATGCAGAAATGCGTGAAGCAGGGAAATCCTCGCTTATCATGGGACTAGT
TGGGATTAGTGAAGGGGCAATTCCTTTCGCGGTGGAATCCCCACTTAAAGTTATTCCGGCTACAGTGCTTGGTTCAGCTG
TCGGCGGGGCACTTGCGGTAGGACTTGGTGCGATTAACCAAGCGCCAATCAGTGGGTTTTATGGCTGGTTCACAGTAGAA
AATTGGCCTGTTTATATTTTAGCTATTGCAGTTGGAACATTAATCGTTGCGGGTATGTCGGTTGCTTTACGGAAAGCAAG
TGCCGGTGAGGAAATGGCAGGCTCTAGCTACGATGATGAAATAGACGAAGCGGAATGGGAAGCATAA

Upstream 100 bases:

>100_bases
AGTAGTACTAGAAGTTCCAGTAAGTGCACCAATTAAAGACGCGGAAAAAGTAATCAACGCAGCACTTGCGTTAATTGATG
AAAAATAAGGAGGAGCAACC

Downstream 100 bases:

>100_bases
AAAACGGAGGTAATTATGGTTAAAGCACATATTGTGAACCATACGCATTGGGACCGAGAGTGGTATTTCACCTCTGCCGA
TGCACTGGTTCTAAGTGAAC

Product: PTS system, fructose-specific, IIC component

Products: NA

Alternate protein names: EIIBBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MFKKIGSELKKHVLTGISYMIPLVIAGAVIMAIARVGGSFFGITDIWDAKYADSANSFISLLHSLDGFGGLALGMMFPVI
AAFIGYSIADKLALAPGLVGGLLARDIGAGFLGALAAGLIAGYTCLLIKKYVKLPKAAASIVPVFLVPVFGTLITVLIIN
YVVGIPFADLNTALENWLNGMSGSNQILMAAIIGAMVGFDLGGPVNKAAVTTAMALLTSGIYAPNTAAQVAIIIPPLGLG
LATLIAKRKYNAEMREAGKSSLIMGLVGISEGAIPFAVESPLKVIPATVLGSAVGGALAVGLGAINQAPISGFYGWFTVE
NWPVYILAIAVGTLIVAGMSVALRKASAGEEMAGSSYDDEIDEAEWEA

Sequences:

>Translated_368_residues
MFKKIGSELKKHVLTGISYMIPLVIAGAVIMAIARVGGSFFGITDIWDAKYADSANSFISLLHSLDGFGGLALGMMFPVI
AAFIGYSIADKLALAPGLVGGLLARDIGAGFLGALAAGLIAGYTCLLIKKYVKLPKAAASIVPVFLVPVFGTLITVLIIN
YVVGIPFADLNTALENWLNGMSGSNQILMAAIIGAMVGFDLGGPVNKAAVTTAMALLTSGIYAPNTAAQVAIIIPPLGLG
LATLIAKRKYNAEMREAGKSSLIMGLVGISEGAIPFAVESPLKVIPATVLGSAVGGALAVGLGAINQAPISGFYGWFTVE
NWPVYILAIAVGTLIVAGMSVALRKASAGEEMAGSSYDDEIDEAEWEA
>Mature_368_residues
MFKKIGSELKKHVLTGISYMIPLVIAGAVIMAIARVGGSFFGITDIWDAKYADSANSFISLLHSLDGFGGLALGMMFPVI
AAFIGYSIADKLALAPGLVGGLLARDIGAGFLGALAAGLIAGYTCLLIKKYVKLPKAAASIVPVFLVPVFGTLITVLIIN
YVVGIPFADLNTALENWLNGMSGSNQILMAAIIGAMVGFDLGGPVNKAAVTTAMALLTSGIYAPNTAAQVAIIIPPLGLG
LATLIAKRKYNAEMREAGKSSLIMGLVGISEGAIPFAVESPLKVIPATVLGSAVGGALAVGLGAINQAPISGFYGWFTVE
NWPVYILAIAVGTLIVAGMSVALRKASAGEEMAGSSYDDEIDEAEWEA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=351, Percent_Identity=39.8860398860399, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1790386, Length=301, Percent_Identity=41.5282392026578, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1786951, Length=322, Percent_Identity=40.3726708074534, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788729, Length=377, Percent_Identity=35.2785145888594, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082348, Length=355, Percent_Identity=31.830985915493, Blast_Score=148, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 37811; Mature: 37811

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKIGSELKKHVLTGISYMIPLVIAGAVIMAIARVGGSFFGITDIWDAKYADSANSFIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHCCHHHHHH
LLHSLDGFGGLALGMMFPVIAAFIGYSIADKLALAPGLVGGLLARDIGAGFLGALAAGLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
AGYTCLLIKKYVKLPKAAASIVPVFLVPVFGTLITVLIINYVVGIPFADLNTALENWLNG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
MSGSNQILMAAIIGAMVGFDLGGPVNKAAVTTAMALLTSGIYAPNTAAQVAIIIPPLGLG
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHH
LATLIAKRKYNAEMREAGKSSLIMGLVGISEGAIPFAVESPLKVIPATVLGSAVGGALAV
HHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
GLGAINQAPISGFYGWFTVENWPVYILAIAVGTLIVAGMSVALRKASAGEEMAGSSYDDE
HHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
IDEAEWEA
CCHHCCCC
>Mature Secondary Structure
MFKKIGSELKKHVLTGISYMIPLVIAGAVIMAIARVGGSFFGITDIWDAKYADSANSFIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHCCHHHHHH
LLHSLDGFGGLALGMMFPVIAAFIGYSIADKLALAPGLVGGLLARDIGAGFLGALAAGLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
AGYTCLLIKKYVKLPKAAASIVPVFLVPVFGTLITVLIINYVVGIPFADLNTALENWLNG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
MSGSNQILMAAIIGAMVGFDLGGPVNKAAVTTAMALLTSGIYAPNTAAQVAIIIPPLGLG
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHH
LATLIAKRKYNAEMREAGKSSLIMGLVGISEGAIPFAVESPLKVIPATVLGSAVGGALAV
HHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
GLGAINQAPISGFYGWFTVENWPVYILAIAVGTLIVAGMSVALRKASAGEEMAGSSYDDE
HHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
IDEAEWEA
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2254279 [H]