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The map label for this gene is mtlR [H]

Identifier: 116871765

GI number: 116871765

Start: 365296

End: 367359

Strand: Direct

Name: mtlR [H]

Synonym: lwe0345

Alternate gene names: 116871765

Gene position: 365296-367359 (Clockwise)

Preceding gene: 116871763

Following gene: 116871766

Centisome position: 12.98

GC content: 34.98

Gene sequence:

>2064_bases
ATGTATATGGATGAGAGAAGTTTGACCTTACTGCAGGAGGTCTTGAAAAATCCAAGTATATCGAATCAGCGTCTGGGAGA
AAAATTTCACTTAACCAGGCGGCAAGTAAGTTATAGCTTTAAGAAAATCAATGAATGGTTACTCGATAATAATTATTCGA
GCATTCAAAAAAATAATCAAGGTCATTTTTTAGTGGATCCGAATGTGACTTTATTATTATCAAAAAAAGATGAAGCAGAT
GCAGAAAAGGAGTATTTACCAACTGAAAAAGAGCGTGTTCATTTATTACTTCTTATGATTTTAACTAGCGAAACCGCACT
TTCAACCTCTCATTTCACTTCGGCGCTCCAGTTTAGTAAAGCGACCATTATGCGAGATATCAAAATGCTTCAACAACTAC
TTAAAAAAGAAGACTTAGAAATCTTGTATACAAGGCAAAATGGATACCAAGTAATTGGAGATGAATGGCAAATTCGTCGC
AAAATGATGGAACTAATCGCGGAAGTCCATCAAATGTTTCACGGGGACAATTATTTAAGAAAATTCACTTCTATTACCAA
AGAAACAATTCAACAAATTTATGAAAAAATTGAACGAGTTGAAAAGAAATTAGAGTTGAAATTCACCGATGAGAAGATTT
TTATTTTACCTTATGTATTCGCTAGTATGCTAAGGCGCATAGAAATGGGTAAAGGGATTAGTTCTTATTTTCAGATTAAT
TATAATGAGTTATCTGACACCAATGAATATCAAGCAGTAGAAATTTTGTTGGAAGGTGTTGCTGATTTAGCGGAGGAAGA
ACGACTTTACATGGCTTTACAATTATTAACAAGTAACGTTTCTTACCAATCTGTTTTGACAGAAAATCAGTTGCCGCGAT
TGAATCGAGCACTGGATGCTATGTTGACGATTTTGGAGGAAAAGGCATTGATTCAATTTAAAAATCGGGTGGAATTGGTT
GAAAAACTATCCCTTCATATGAAGCCCGCTTATTATCGAATCAAATACCATTTAACGATGAGTTTTATGATTCCAGATGT
TATTCATGAAGAATTTAATGCGCTTCATTTTTTAGTAAAGGAGTCTATCTGGCCACTTGAAAACTTTATTGGGGAAACAA
TTCCAGATGAAGAAATTTATTTTATCACGTTATTTATTGGTGGTCATTTAATTAAAACTGGTGAAATAACGCAACATAAA
AAGCCCAGTGCCATTGTTATTTGCCCAAATGGTGTTAGTATTTCTAAATTAATTGAAAGCCAATTAGCTAAATTGTTTCC
TGAATTTCATTTTTGGCAGACGATGTCCATTCGAGAGTTTGAGAAAACAGCGCCAAATGTGGATGTAGTGTTTTCGGTGA
CCCCAGTTGAAACGACTTGTAAACTTTATATTATGAGCCATTATATGAGCTTTGAAGAACAGCAGCGATTACGTCAAAGA
GTGATGAATGAAGTATTTCATGTGGTTACCGAGTCACTTGATTTAGAGCAACTATTGGCGCGGATTGAGCAACACGTCGA
AGTAACAGATCGTTCCAACTTAAAAAAAGAACTATATGGCTTTTTTCAAGAAAAAGATCGTAACAAAGTAACTGATTTTC
AAAAAGAAGAGATTGAATATTGTTTGGAAGATTTAATGAGTTCAAATATGACTCGTGTTGTAAAGAGCGTTCCAAATTGG
CATACGGCAATCGAACTGACAGCTGCACCGCTTTTAGAAGCTGGTTTCATTGATCAAACTTATGTAAATGCAATGAAGTC
TCTTTACCCTGAAATAGCCCCATATATCGTTCTAAAAGGCAATATTTTACTGCCACATGCAAGACCGGAAGACGGTGTAA
ATAAATTTGGCCTTTCCATTTTGAAAGTGGAAGATGGACTAATCTTTAATGGGAAAAAGATTCATCTGCTCGTTGTGCTG
GCTCCGGTGGATAAAAAGAAGCATTTGACGGCGATGTTTCAACTACTTACAATTGCTTCCAATCAACAAGTGATAGACAA
ATTAAAAAACGCAACTAGCGGGACGGCGATTTGTCAGATATTTAAAGAGAATTTAACAAAATAA

Upstream 100 bases:

>100_bases
TTGTGTTCAATTGGGTGACTACTTTTGAATATGAAAACGCATACAAAATGTGAAATATCTATGTTATATTGAATTTAGAC
CTGAGAGGGAGGGAGATAAG

Downstream 100 bases:

>100_bases
AAAATAGAAAGGAAGTGATGAGATGAAAATGGTGCATGAGGAGTTAGTATTTCCGGGGCTTACCGCTTCTAATTATGAAG
AGGTTATTAAGTTAGTTGGA

Product: PRD/PTS system IIA 2 domain-containing regulatory protein

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MYMDERSLTLLQEVLKNPSISNQRLGEKFHLTRRQVSYSFKKINEWLLDNNYSSIQKNNQGHFLVDPNVTLLLSKKDEAD
AEKEYLPTEKERVHLLLLMILTSETALSTSHFTSALQFSKATIMRDIKMLQQLLKKEDLEILYTRQNGYQVIGDEWQIRR
KMMELIAEVHQMFHGDNYLRKFTSITKETIQQIYEKIERVEKKLELKFTDEKIFILPYVFASMLRRIEMGKGISSYFQIN
YNELSDTNEYQAVEILLEGVADLAEEERLYMALQLLTSNVSYQSVLTENQLPRLNRALDAMLTILEEKALIQFKNRVELV
EKLSLHMKPAYYRIKYHLTMSFMIPDVIHEEFNALHFLVKESIWPLENFIGETIPDEEIYFITLFIGGHLIKTGEITQHK
KPSAIVICPNGVSISKLIESQLAKLFPEFHFWQTMSIREFEKTAPNVDVVFSVTPVETTCKLYIMSHYMSFEEQQRLRQR
VMNEVFHVVTESLDLEQLLARIEQHVEVTDRSNLKKELYGFFQEKDRNKVTDFQKEEIEYCLEDLMSSNMTRVVKSVPNW
HTAIELTAAPLLEAGFIDQTYVNAMKSLYPEIAPYIVLKGNILLPHARPEDGVNKFGLSILKVEDGLIFNGKKIHLLVVL
APVDKKKHLTAMFQLLTIASNQQVIDKLKNATSGTAICQIFKENLTK

Sequences:

>Translated_687_residues
MYMDERSLTLLQEVLKNPSISNQRLGEKFHLTRRQVSYSFKKINEWLLDNNYSSIQKNNQGHFLVDPNVTLLLSKKDEAD
AEKEYLPTEKERVHLLLLMILTSETALSTSHFTSALQFSKATIMRDIKMLQQLLKKEDLEILYTRQNGYQVIGDEWQIRR
KMMELIAEVHQMFHGDNYLRKFTSITKETIQQIYEKIERVEKKLELKFTDEKIFILPYVFASMLRRIEMGKGISSYFQIN
YNELSDTNEYQAVEILLEGVADLAEEERLYMALQLLTSNVSYQSVLTENQLPRLNRALDAMLTILEEKALIQFKNRVELV
EKLSLHMKPAYYRIKYHLTMSFMIPDVIHEEFNALHFLVKESIWPLENFIGETIPDEEIYFITLFIGGHLIKTGEITQHK
KPSAIVICPNGVSISKLIESQLAKLFPEFHFWQTMSIREFEKTAPNVDVVFSVTPVETTCKLYIMSHYMSFEEQQRLRQR
VMNEVFHVVTESLDLEQLLARIEQHVEVTDRSNLKKELYGFFQEKDRNKVTDFQKEEIEYCLEDLMSSNMTRVVKSVPNW
HTAIELTAAPLLEAGFIDQTYVNAMKSLYPEIAPYIVLKGNILLPHARPEDGVNKFGLSILKVEDGLIFNGKKIHLLVVL
APVDKKKHLTAMFQLLTIASNQQVIDKLKNATSGTAICQIFKENLTK
>Mature_687_residues
MYMDERSLTLLQEVLKNPSISNQRLGEKFHLTRRQVSYSFKKINEWLLDNNYSSIQKNNQGHFLVDPNVTLLLSKKDEAD
AEKEYLPTEKERVHLLLLMILTSETALSTSHFTSALQFSKATIMRDIKMLQQLLKKEDLEILYTRQNGYQVIGDEWQIRR
KMMELIAEVHQMFHGDNYLRKFTSITKETIQQIYEKIERVEKKLELKFTDEKIFILPYVFASMLRRIEMGKGISSYFQIN
YNELSDTNEYQAVEILLEGVADLAEEERLYMALQLLTSNVSYQSVLTENQLPRLNRALDAMLTILEEKALIQFKNRVELV
EKLSLHMKPAYYRIKYHLTMSFMIPDVIHEEFNALHFLVKESIWPLENFIGETIPDEEIYFITLFIGGHLIKTGEITQHK
KPSAIVICPNGVSISKLIESQLAKLFPEFHFWQTMSIREFEKTAPNVDVVFSVTPVETTCKLYIMSHYMSFEEQQRLRQR
VMNEVFHVVTESLDLEQLLARIEQHVEVTDRSNLKKELYGFFQEKDRNKVTDFQKEEIEYCLEDLMSSNMTRVVKSVPNW
HTAIELTAAPLLEAGFIDQTYVNAMKSLYPEIAPYIVLKGNILLPHARPEDGVNKFGLSILKVEDGLIFNGKKIHLLVVL
APVDKKKHLTAMFQLLTIASNQQVIDKLKNATSGTAICQIFKENLTK

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1789302, Length=113, Percent_Identity=32.7433628318584, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 79981; Mature: 79981

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMDERSLTLLQEVLKNPSISNQRLGEKFHLTRRQVSYSFKKINEWLLDNNYSSIQKNNQ
CCCCCHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
GHFLVDPNVTLLLSKKDEADAEKEYLPTEKERVHLLLLMILTSETALSTSHFTSALQFSK
CCEEECCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ATIMRDIKMLQQLLKKEDLEILYTRQNGYQVIGDEWQIRRKMMELIAEVHQMFHGDNYLR
HHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHH
KFTSITKETIQQIYEKIERVEKKLELKFTDEKIFILPYVFASMLRRIEMGKGISSYFQIN
HHHHHHHHHHHHHHHHHHHHHHHHCEEECCCEEEEHHHHHHHHHHHHHHCCCCCHHEEEE
YNELSDTNEYQAVEILLEGVADLAEEERLYMALQLLTSNVSYQSVLTENQLPRLNRALDA
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
MLTILEEKALIQFKNRVELVEKLSLHMKPAYYRIKYHLTMSFMIPDVIHEEFNALHFLVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
ESIWPLENFIGETIPDEEIYFITLFIGGHLIKTGEITQHKKPSAIVICPNGVSISKLIES
HHCCCHHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHH
QLAKLFPEFHFWQTMSIREFEKTAPNVDVVFSVTPVETTCKLYIMSHYMSFEEQQRLRQR
HHHHHCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHH
VMNEVFHVVTESLDLEQLLARIEQHVEVTDRSNLKKELYGFFQEKDRNKVTDFQKEEIEY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CLEDLMSSNMTRVVKSVPNWHTAIELTAAPLLEAGFIDQTYVNAMKSLYPEIAPYIVLKG
HHHHHHHCCHHHHHHHCCCCHHEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEC
NILLPHARPEDGVNKFGLSILKVEDGLIFNGKKIHLLVVLAPVDKKKHLTAMFQLLTIAS
CEEECCCCCCCCHHHHCCEEEEEECCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHCC
NQQVIDKLKNATSGTAICQIFKENLTK
CHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MYMDERSLTLLQEVLKNPSISNQRLGEKFHLTRRQVSYSFKKINEWLLDNNYSSIQKNNQ
CCCCCHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
GHFLVDPNVTLLLSKKDEADAEKEYLPTEKERVHLLLLMILTSETALSTSHFTSALQFSK
CCEEECCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ATIMRDIKMLQQLLKKEDLEILYTRQNGYQVIGDEWQIRRKMMELIAEVHQMFHGDNYLR
HHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHH
KFTSITKETIQQIYEKIERVEKKLELKFTDEKIFILPYVFASMLRRIEMGKGISSYFQIN
HHHHHHHHHHHHHHHHHHHHHHHHCEEECCCEEEEHHHHHHHHHHHHHHCCCCCHHEEEE
YNELSDTNEYQAVEILLEGVADLAEEERLYMALQLLTSNVSYQSVLTENQLPRLNRALDA
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
MLTILEEKALIQFKNRVELVEKLSLHMKPAYYRIKYHLTMSFMIPDVIHEEFNALHFLVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
ESIWPLENFIGETIPDEEIYFITLFIGGHLIKTGEITQHKKPSAIVICPNGVSISKLIES
HHCCCHHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHH
QLAKLFPEFHFWQTMSIREFEKTAPNVDVVFSVTPVETTCKLYIMSHYMSFEEQQRLRQR
HHHHHCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHH
VMNEVFHVVTESLDLEQLLARIEQHVEVTDRSNLKKELYGFFQEKDRNKVTDFQKEEIEY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CLEDLMSSNMTRVVKSVPNWHTAIELTAAPLLEAGFIDQTYVNAMKSLYPEIAPYIVLKG
HHHHHHHCCHHHHHHHCCCCHHEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEC
NILLPHARPEDGVNKFGLSILKVEDGLIFNGKKIHLLVVLAPVDKKKHLTAMFQLLTIAS
CEEECCCCCCCCHHHHCCEEEEEECCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHCC
NQQVIDKLKNATSGTAICQIFKENLTK
CHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]