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The map label for this gene is ipk [H]

Identifier: 116871579

GI number: 116871579

Start: 159141

End: 160016

Strand: Direct

Name: ipk [H]

Synonym: lwe0159

Alternate gene names: 116871579

Gene position: 159141-160016 (Clockwise)

Preceding gene: 116871578

Following gene: 116871580

Centisome position: 5.66

GC content: 39.04

Gene sequence:

>876_bases
ATGAAAATAAGCATAACAGCACCAGCTAAAATTAATCTTTCACTTGACGCGCTGTACAAACGTGAAGACGGCTATCATGA
AGTGGAAATGGTGATGACAACAATAGACCTTGCTGACAGATTAAGCTTAGAACGCTTAGACGAGGATAAGATTGTGCTAG
ATGTAAAAGCGCATTTTATCCCAGAAGATCGTCGTAATTTAATTTACCAAGCGGCTCTTCTTTTGAAAAAACGTTTTAAC
GTAAAAATGGGTGTACGCATTATAATTGATAAACACATTCCAGTTTCCGCGGGACTTGCTGGTGGTAGTTCGGATGCGGC
CGCGGCGCTGAAAGGTTTAAACATAATTTGGGAACTTGGACTTTCGATAGAAGAATTAGCAGAAATAAGCTCAGAAATTG
GTTCTGATATTGCTTTTTGTGTATATGGAGGAACGGCTCTTGCTACCGGACGCGGAGAAAAAATTACAGCTTTACCTAAT
ATTCCGGGTTGCTGGATTGTATTAGCTAAACCGAGTATTAGTGTTTCTACACCTACTATTTATAAAGAATTACAAGTAGA
AAATGTTGAACATCCTAATACAAAGAAAATGATAGAATCCATCAAAATTGGCGACTTAGATGGGATTTTTGCTTCAACCG
GAAATGTTTTGGAATCTGTGACTTTAGAAAAAAATCCACAAGTGAAACGAATTAAAGATCGGATGATGGCATTTGGTGCT
GAGGCAGCGTTAATGAGTGGTAGCGGCCCAACAGTATTTGCGCTCATCAAACAGTATTCAAGAGCAAAACGTGTCTATAA
CGGCTTGCGAGGCTTTTGTGAGGAAGTCTATATGGTTAGACCGTGGAGCGAAAGTGAAAACGAAACTATTAATTAA

Upstream 100 bases:

>100_bases
GTTTTTGCTTTACATAACCCAGTTTTGGACCGCCTGCTACATATTTCTTCTTTCATATGATAGAATAGAAAAAGAGATTT
TGAACGCGGAGGCCGAGAAA

Downstream 100 bases:

>100_bases
TGGATGAGAGGGGTCAAACAAATGAAAATTATTTTTAATGCAGATGATTTTGGAATTAGCCCAGGAGCAGTTTATGGTAT
TTTAGAATCGTACAAAAAAG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLSLERLDEDKIVLDVKAHFIPEDRRNLIYQAALLLKKRFN
VKMGVRIIIDKHIPVSAGLAGGSSDAAAALKGLNIIWELGLSIEELAEISSEIGSDIAFCVYGGTALATGRGEKITALPN
IPGCWIVLAKPSISVSTPTIYKELQVENVEHPNTKKMIESIKIGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMMAFGA
EAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSESENETIN

Sequences:

>Translated_291_residues
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLSLERLDEDKIVLDVKAHFIPEDRRNLIYQAALLLKKRFN
VKMGVRIIIDKHIPVSAGLAGGSSDAAAALKGLNIIWELGLSIEELAEISSEIGSDIAFCVYGGTALATGRGEKITALPN
IPGCWIVLAKPSISVSTPTIYKELQVENVEHPNTKKMIESIKIGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMMAFGA
EAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSESENETIN
>Mature_291_residues
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLSLERLDEDKIVLDVKAHFIPEDRRNLIYQAALLLKKRFN
VKMGVRIIIDKHIPVSAGLAGGSSDAAAALKGLNIIWELGLSIEELAEISSEIGSDIAFCVYGGTALATGRGEKITALPN
IPGCWIVLAKPSISVSTPTIYKELQVENVEHPNTKKMIESIKIGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMMAFGA
EAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSESENETIN

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [H]

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787459, Length=272, Percent_Identity=32.7205882352941, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.148 [H]

Molecular weight: Translated: 32013; Mature: 32013

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLSLERLDEDKIVLDVKAHFI
CEEEEECCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
PEDRRNLIYQAALLLKKRFNVKMGVRIIIDKHIPVSAGLAGGSSDAAAALKGLNIIWELG
CCHHHHHHHHHHHHHHHHCCCEECEEEEEECCCCCCCCCCCCCCHHHHHHHHHHEEHHCC
LSIEELAEISSEIGSDIAFCVYGGTALATGRGEKITALPNIPGCWIVLAKPSISVSTPTI
CCHHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCHH
YKELQVENVEHPNTKKMIESIKIGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMMAFGA
HHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHCCCHHHHHEECCCCCCHHHHHHHHHHHCC
EAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSESENETIN
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLSLERLDEDKIVLDVKAHFI
CEEEEECCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
PEDRRNLIYQAALLLKKRFNVKMGVRIIIDKHIPVSAGLAGGSSDAAAALKGLNIIWELG
CCHHHHHHHHHHHHHHHHCCCEECEEEEEECCCCCCCCCCCCCCHHHHHHHHHHEEHHCC
LSIEELAEISSEIGSDIAFCVYGGTALATGRGEKITALPNIPGCWIVLAKPSISVSTPTI
CCHHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCHH
YKELQVENVEHPNTKKMIESIKIGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMMAFGA
HHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHCCCHHHHHEECCCCCCHHHHHHHHHHHCC
EAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSESENETIN
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA