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The map label for this gene is dnaC [H]

Identifier: 116871467

GI number: 116871467

Start: 43502

End: 44854

Strand: Direct

Name: dnaC [H]

Synonym: lwe0045

Alternate gene names: 116871467

Gene position: 43502-44854 (Clockwise)

Preceding gene: 116871466

Following gene: 116871468

Centisome position: 1.55

GC content: 41.83

Gene sequence:

>1353_bases
GTGGATAATAATTTTCAGGACAGAACACCACCACAAAATATTGAAGCCGAACAAGCTGTACTGGGCGCGATATTTCTTGA
GCCGAATGCGCTGATTACTGCTTCTGAAATTTTAATGCCGGATGATTTTTATCGGACTGGTCATCAAATCATTTTTGAAA
CGATGCTTGATTTGAATGACCACGGGAAAGCTGTCGATGTTTTAACTGTGTATGAGGCGCTTGCTGCTAAGGGTAATTTA
GAAGATGCGGGCGGTTTGCCTTATTTGACGGAATTATCTGGTGCTGTGCCGACTGCAGCTAACTTAGAATACTATGCTCA
TATTATCGAGGACAAGGCGCTTTTAAGGCGTTTAATTAGAACTGCTACCCAGATTGCAACAGATGGCTATTCGCGCGAGG
ATGAGCTCGATATGCTTATGGACGAAGCGGAAAAGAGTATCTTGGAAGTTTCGCAACGTAAAAATGTCGGTGCGTTTAAG
AATATTAAAGATGTTCTTGTTAAAACATATGACGATATTGAGATTTTGCATAATCGTAAAGGTGATATTACAGGGATTCC
AACTGGATTTAACGAGCTGGACAAAATGACAGCTGGCTTTCAACGGAATGATTTAATTATTGTTGCGGCTCGTCCTTCTG
TTGGTAAAACCGCATTTGCCTTAAATATCGCACAGAACGTAGCGACGAAAACCGATGAGAATGTAGCTATTTTCAGTTTG
GAAATGGGCGCGGAACAACTCGTAATGCGTATGCTTTGTGCGGAAGGAAATATTAATGCGCAGAATTTACGGACAGGTGC
TTTAACAAGCGATGATTGGCAAAAGCTGACAATTGCTATGGGAACACTTTCTAATTCTGGGATTTATATTGATGATACGC
CGGGTGTTCGGGTGAATGAGATTCGTTCGAAATGTCGTCGTTTAAAACAAGAAACTGGTCTTGGTATGATCGTGATTGAT
TACTTGCAACTGATTGCAGGGAGCGGTCGCGGTGGTGAGAACCGGCAACAAGAGGTTTCTGAAATTTCTAGGTCATTAAA
AGCTTTGGCGCGGGAACTTGAAGTACCAGTAATTGCGCTTTCGCAGTTATCTCGTAGTGTAGAGCAGCGTCAAGATAAGC
GACCGATGATGTCAGATATCCGTGAATCTGGTTCTATTGAGCAAGATGCGGATATTGTAGCCTTTTTATACCGAGAAGAT
TACTATGATCGAGAAGGCGAAAACGATGGTACAATTGAGATTATTATTGCGAAACAACGTAATGGTCCGGTTGGCGATGT
GAAACTGGCCTTTGTAAAAGAATATAATAAGTTTGTGAATTTAGAAGTGCGTTACGACGACGCAATGGCTTAA

Upstream 100 bases:

>100_bases
AGGACATACGAAAGTGCCTGTGAAATTGCACCACGAAGTAACGGCAACACTTGATGTACATGTTAGTGAAGAATAATTTT
TCTTAAGGGAGCGTAAGACA

Downstream 100 bases:

>100_bases
TGAGGAAACCTTGTGAATTTCTAATTTGATTTAGAGTTCACAAGGTTTTTTGTTTTATGTAAAAAGGTATCGTATAATGA
AAAACAGTCGTGGAAACTCT

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLNDHGKAVDVLTVYEALAAKGNL
EDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIRTATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFK
NIKDVLVKTYDDIEILHNRKGDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSL
EMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNEIRSKCRRLKQETGLGMIVID
YLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIALSQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRED
YYDREGENDGTIEIIIAKQRNGPVGDVKLAFVKEYNKFVNLEVRYDDAMA

Sequences:

>Translated_450_residues
MDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLNDHGKAVDVLTVYEALAAKGNL
EDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIRTATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFK
NIKDVLVKTYDDIEILHNRKGDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSL
EMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNEIRSKCRRLKQETGLGMIVID
YLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIALSQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRED
YYDREGENDGTIEIIIAKQRNGPVGDVKLAFVKEYNKFVNLEVRYDDAMA
>Mature_450_residues
MDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLNDHGKAVDVLTVYEALAAKGNL
EDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIRTATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFK
NIKDVLVKTYDDIEILHNRKGDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSL
EMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNEIRSKCRRLKQETGLGMIVID
YLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIALSQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRED
YYDREGENDGTIEIIIAKQRNGPVGDVKLAFVKEYNKFVNLEVRYDDAMA

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=448, Percent_Identity=45.9821428571429, Blast_Score=381, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 50036; Mature: 50036

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLND
CCCCCCCCCCCCCCCHHHHHHHHEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCCCC
HGKAVDVLTVYEALAAKGNLEDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIR
CCCEEHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFKNIKDVLVKTYDDIEILHNRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCC
GDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHEEEHHHHHHHCCCCCCEEEEEE
EMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNE
CCCHHHHHHHHHHCCCCCCHHHCEECCCCCCCHHEEEEEEECCCCCCEEEECCCCCCHHH
IRSKCRRLKQETGLGMIVIDYLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIAL
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
SQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYDREGENDGTIEIIIAKQR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEEEHHHHCCCCCCCCCCEEEEEEEECC
NGPVGDVKLAFVKEYNKFVNLEVRYDDAMA
CCCCCCEEHHHHHHHHHEEEEEEECCCCCC
>Mature Secondary Structure
MDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLND
CCCCCCCCCCCCCCCHHHHHHHHEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCCCC
HGKAVDVLTVYEALAAKGNLEDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIR
CCCEEHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFKNIKDVLVKTYDDIEILHNRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCC
GDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHEEEHHHHHHHCCCCCCEEEEEE
EMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNE
CCCHHHHHHHHHHCCCCCCHHHCEECCCCCCCHHEEEEEEECCCCCCEEEECCCCCCHHH
IRSKCRRLKQETGLGMIVIDYLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIAL
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
SQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYDREGENDGTIEIIIAKQR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEEEHHHHCCCCCCCCCCEEEEEEEECC
NGPVGDVKLAFVKEYNKFVNLEVRYDDAMA
CCCCCCEEHHHHHHHHHEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]