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The map label for this gene is narL2 [H]

Identifier: 116696270

GI number: 116696270

Start: 2645664

End: 2646320

Strand: Direct

Name: narL2 [H]

Synonym: H16_B2334

Alternate gene names: 116696270

Gene position: 2645664-2646320 (Clockwise)

Preceding gene: 116696269

Following gene: 116696271

Centisome position: 90.84

GC content: 68.8

Gene sequence:

>657_bases
ATGACCATCCGCATCCTGCTGATCGACGACCACACCCTGTTCCGCTCCGGCATCCGTGCGCTGCTGCAGCGGCAGGCCGA
CTTCGAGATCGTCGACGAAGCCGCCGACGGCGTGGAAGGCATCAAGCGCGCCAAGCAGCACCGTCCCGACGTGATCCTGC
TGGACCTGAACATGCCCGGCCTGTCCGGCCTGGAGGCCCTGCAGCTGCTGGTGGAAGACCTGCCGCGGACCGCCGTGATC
GTGCTGACCGTGTCCGAGGAAGCCGAGGAACTGGCTGCCGCGCTGCGCGGCGGCGCGCGCGGCTACCTGATCAAGAATAT
CGAGACCGAGGCGCTGATCGCCGGCATCCGCCGTGCCGCGGCCGGCGAGCCGGTCATCTCCGACAGCATGACCGCCAAGC
TGGTGGCCCAGTTCCGCGCTCCCGCACCGGTGGCCGCGGCGCGCCAGGACGAAGCGCCGCGGCTGACCGCGCGCGAGCGC
GAGATCGTGCAGGGCCTGGCGCGCGGCGAAAGCAACAAGGAGATCGCGCGCGACCTGGGTGTGGCGGAAAGCACGGTGAA
GATCCACGTGCAGAACATCCTGAAGAAGCTGAACCTGGCCAGCCGCGTGCAGGTGGCCGTCTATGCCGTCGAACACGGGC
TGAACGCAGCGTTCTGA

Upstream 100 bases:

>100_bases
ACGGCGTGCGCATCGAACTGGTGCTGCCCGCCGGCCGCTCTTCCGGCGCCCGCGAGTTCGCCGACACCCGCCCCGCCCCC
ACGACCACCGAGACCCAGCC

Downstream 100 bases:

>100_bases
ACGCGGCGCAGTGGCCGCCACGACAGCCCTGCATGTTGCGCGTCCGGCACCCCAACGTCGTCCGATTCCTACAGCGATTT
CAGCCCTAGTCCGGGGGGAC

Product: response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTIRILLIDDHTLFRSGIRALLQRQADFEIVDEAADGVEGIKRAKQHRPDVILLDLNMPGLSGLEALQLLVEDLPRTAVI
VLTVSEEAEELAAALRGGARGYLIKNIETEALIAGIRRAAAGEPVISDSMTAKLVAQFRAPAPVAAARQDEAPRLTARER
EIVQGLARGESNKEIARDLGVAESTVKIHVQNILKKLNLASRVQVAVYAVEHGLNAAF

Sequences:

>Translated_218_residues
MTIRILLIDDHTLFRSGIRALLQRQADFEIVDEAADGVEGIKRAKQHRPDVILLDLNMPGLSGLEALQLLVEDLPRTAVI
VLTVSEEAEELAAALRGGARGYLIKNIETEALIAGIRRAAAGEPVISDSMTAKLVAQFRAPAPVAAARQDEAPRLTARER
EIVQGLARGESNKEIARDLGVAESTVKIHVQNILKKLNLASRVQVAVYAVEHGLNAAF
>Mature_217_residues
TIRILLIDDHTLFRSGIRALLQRQADFEIVDEAADGVEGIKRAKQHRPDVILLDLNMPGLSGLEALQLLVEDLPRTAVIV
LTVSEEAEELAAALRGGARGYLIKNIETEALIAGIRRAAAGEPVISDSMTAKLVAQFRAPAPVAAARQDEAPRLTARERE
IVQGLARGESNKEIARDLGVAESTVKIHVQNILKKLNLASRVQVAVYAVEHGLNAAF

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=39.5238095238095, Blast_Score=145, Evalue=1e-36,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=45.5882352941176, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=30.4147465437788, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790102, Length=205, Percent_Identity=35.1219512195122, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=26.3414634146341, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082052, Length=106, Percent_Identity=39.622641509434, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788712, Length=204, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=35.2380952380952, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788224, Length=128, Percent_Identity=32.03125, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789937, Length=205, Percent_Identity=23.9024390243902, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23590; Mature: 23458

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRILLIDDHTLFRSGIRALLQRQADFEIVDEAADGVEGIKRAKQHRPDVILLDLNMPG
CEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
LSGLEALQLLVEDLPRTAVIVLTVSEEAEELAAALRGGARGYLIKNIETEALIAGIRRAA
CCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHC
AGEPVISDSMTAKLVAQFRAPAPVAAARQDEAPRLTAREREIVQGLARGESNKEIARDLG
CCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCC
VAESTVKIHVQNILKKLNLASRVQVAVYAVEHGLNAAF
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TIRILLIDDHTLFRSGIRALLQRQADFEIVDEAADGVEGIKRAKQHRPDVILLDLNMPG
EEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
LSGLEALQLLVEDLPRTAVIVLTVSEEAEELAAALRGGARGYLIKNIETEALIAGIRRAA
CCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHC
AGEPVISDSMTAKLVAQFRAPAPVAAARQDEAPRLTAREREIVQGLARGESNKEIARDLG
CCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCC
VAESTVKIHVQNILKKLNLASRVQVAVYAVEHGLNAAF
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]