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The map label for this gene is sqhC [H]

Identifier: 116696143

GI number: 116696143

Start: 2505182

End: 2507200

Strand: Direct

Name: sqhC [H]

Synonym: H16_B2207

Alternate gene names: 116696143

Gene position: 2505182-2507200 (Clockwise)

Preceding gene: 116696142

Following gene: 116696144

Centisome position: 86.02

GC content: 71.77

Gene sequence:

>2019_bases
ATGTCGATGAACGAGACCGCCTTTGCCACGGCAGTGCCACGGATTGCGCCGGCCAGCGCGGGGGACAGCCCCGCGCCGCG
CGACGCCGCGCAGGCATTGGACCAGGGCATCGGCCGCGCGATCGACGCGCTGCTGCACCAGCAGCGCCCCGACGGCCACT
GGGTCTACGAACTGGAAGCCGACGCCACCATTCCCGCCGAATACGTGCTGATGGTGCACTACCTCGGCGAAGCCCCGGAC
CTGGAGCTTGAAGCCCGCCTGGCCCGCTACCTGCGCCGCATCCAGAATCCCGATGGCGGCTGGCCGCTGTTCCATGAAGG
CCGCTCCGACGTCAGCGCCAGCGTAAAGGCCTATTTCGCGCTGAAGATGGCCGGCGACGACCCCCAGGCCGCGCATATGC
AGCGCGCGCGCCGGGCCGTCCACGCGCTGGGCGGCGCCGAGGCCAGCAATGTATTCACGCGCACGCTGCTGGCCCTGTAC
GGCGTGATGCCATGGTTGGCGGTGCCGATGATGCCGGTCGAGATCATGCTGCTGCCGCAGTGGTTTCCGTTCCACCTGTC
CAAGGTCTCGTACTGGGCGCGCACGGTGATCGTGCCGCTGCTGGTGCTGAACAGCCTGCGCCCGCAGGCGCGCAACCCGC
GCGGGGTCGGCATCAATGAGCTGTTCGTCGGCAACTGCCATACGGTGGGGCTGCCGCCGCGCGCGGCGCACCAGCACGCC
GGCTGGTACACGGTGTTCCGCGGCCTGGACGCGCTGCTGCGCGTGGCCGAGCCGCTCGTCCCGCGCACGCTGCGCCGGCG
CGCCATTGCCGCGGCGCAGGCCTTCGTGCGCGAGCGGCTCAACGGCGAGGACGGCCTGGGCGCCATCTTCCCGGCAATGG
CCAACAGCGTGATGATGTTCGACGTGCTGGGCGTGCCGCCCGACGATCCGGCACGCGCGCTGGCGCGGCAATCCGTCGAG
CGGCTGCTGGTCGAGCACGGCGACGAAGCCTATTGCCAGCCCTGCCTGTCGCCGGTGTGGGATACCGCGCTGGCCGCGCA
CGCGCTGCTGGAAACCGGCGAGGCACGCGCGACGGCCGCGGCCGGGCGCGGCCTGGACTGGCTCAGGCCGCTGCAAGTGC
TGGACGTGCGCGGCGACTGGGCCGTGCGCCGCCCCCTGGTGCGCCCCGGCGGCTGGGCCTTCCAGTACGCCAATGCCTAT
TACCCGGACGTGGACGACACCGCCGTGGTGGCCGCCGCGATGAACCGCTACATGCGCGCGCACGATGTGCCGGGCCGCTA
TGACGAAGCCGTGGCGCGCGCCGCCGAGTGGATCGTCGGCATGCAGGGCGGCGACGGCGGCTGGGGCGCGTTCGAGCCCG
AGAACACGCATCTCTACCTGAACAACATCCCCTTTGCCGACCATGGCGCGCTGCTGGACCCGCCCACCGCGGACGTATCC
GCGCGCTGCCTGTCGATGCTGTGCCAGATCGGCGCCACGCCGGGCAAGAGCGAACCCGCCGCGCGCGCCCTGCGCTACCT
GCTGGCCGAGCAGATGCCCGACGGCAGCTGGTTTGGCCGCTGGGGCACCAACTATATCTATGGCACCTGGAGCGCGCTGT
GCGCGCTGAACGCAACGGGCCTGGCACCGGAAGCCCCCGAGATGCGCCGCGCCGTGGCGTGGCTCGAGCAGATCCAGAAC
GCCGACGGCGGCTGGGGCGAGGACGGCAGCAGCTACCGGCTCGACTACCGCGGCTACGAGCCCGCGCCGAGCGTGGCCTC
GCAGACCGCGTGGGCGCTGCTGGCGCTGATGGCAGCCGGCGCCGCGCAGCATGCCGCGGTGGCGCGCGGCATCGACTACC
TGCTGCGCACGCAGCAATCCGGCGGCCTGTGGCATGAGCCGCGCTTCACCGCCGTGGGCTTTCCGCGCGTGTTCTACCTG
CGCTATCACGGCTATGCACGCTACTTCCCGCTGTGGGCGCTGGCGCGCTACCGCAACCTGCAGCGCGGCGGCGCGCACCA
GGTGCCGTGGGGGCTGTGA

Upstream 100 bases:

>100_bases
CCCAATTGCTCTGGATCTTGCTGCGCCACGCCATTGGCTGAGCGCTGCCCCCGATGCATGCCGGGCGCGGCCGCGCCGTG
CGCCGGCACAAGGAGTCTGC

Downstream 100 bases:

>100_bases
CGGCACCGTTCGTGCTGGTCGTCACCGGCATGGCGTTCGAGGCGCGCACCGCCGCCGGTCCGCATTGCCGCGTGGTGCAC
GGCCTGCGCGGACTTGCACT

Product: squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MSMNETAFATAVPRIAPASAGDSPAPRDAAQALDQGIGRAIDALLHQQRPDGHWVYELEADATIPAEYVLMVHYLGEAPD
LELEARLARYLRRIQNPDGGWPLFHEGRSDVSASVKAYFALKMAGDDPQAAHMQRARRAVHALGGAEASNVFTRTLLALY
GVMPWLAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRGVGINELFVGNCHTVGLPPRAAHQHA
GWYTVFRGLDALLRVAEPLVPRTLRRRAIAAAQAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPARALARQSVE
RLLVEHGDEAYCQPCLSPVWDTALAAHALLETGEARATAAAGRGLDWLRPLQVLDVRGDWAVRRPLVRPGGWAFQYANAY
YPDVDDTAVVAAAMNRYMRAHDVPGRYDEAVARAAEWIVGMQGGDGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVS
ARCLSMLCQIGATPGKSEPAARALRYLLAEQMPDGSWFGRWGTNYIYGTWSALCALNATGLAPEAPEMRRAVAWLEQIQN
ADGGWGEDGSSYRLDYRGYEPAPSVASQTAWALLALMAAGAAQHAAVARGIDYLLRTQQSGGLWHEPRFTAVGFPRVFYL
RYHGYARYFPLWALARYRNLQRGGAHQVPWGL

Sequences:

>Translated_672_residues
MSMNETAFATAVPRIAPASAGDSPAPRDAAQALDQGIGRAIDALLHQQRPDGHWVYELEADATIPAEYVLMVHYLGEAPD
LELEARLARYLRRIQNPDGGWPLFHEGRSDVSASVKAYFALKMAGDDPQAAHMQRARRAVHALGGAEASNVFTRTLLALY
GVMPWLAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRGVGINELFVGNCHTVGLPPRAAHQHA
GWYTVFRGLDALLRVAEPLVPRTLRRRAIAAAQAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPARALARQSVE
RLLVEHGDEAYCQPCLSPVWDTALAAHALLETGEARATAAAGRGLDWLRPLQVLDVRGDWAVRRPLVRPGGWAFQYANAY
YPDVDDTAVVAAAMNRYMRAHDVPGRYDEAVARAAEWIVGMQGGDGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVS
ARCLSMLCQIGATPGKSEPAARALRYLLAEQMPDGSWFGRWGTNYIYGTWSALCALNATGLAPEAPEMRRAVAWLEQIQN
ADGGWGEDGSSYRLDYRGYEPAPSVASQTAWALLALMAAGAAQHAAVARGIDYLLRTQQSGGLWHEPRFTAVGFPRVFYL
RYHGYARYFPLWALARYRNLQRGGAHQVPWGL
>Mature_671_residues
SMNETAFATAVPRIAPASAGDSPAPRDAAQALDQGIGRAIDALLHQQRPDGHWVYELEADATIPAEYVLMVHYLGEAPDL
ELEARLARYLRRIQNPDGGWPLFHEGRSDVSASVKAYFALKMAGDDPQAAHMQRARRAVHALGGAEASNVFTRTLLALYG
VMPWLAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRGVGINELFVGNCHTVGLPPRAAHQHAG
WYTVFRGLDALLRVAEPLVPRTLRRRAIAAAQAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPARALARQSVER
LLVEHGDEAYCQPCLSPVWDTALAAHALLETGEARATAAAGRGLDWLRPLQVLDVRGDWAVRRPLVRPGGWAFQYANAYY
PDVDDTAVVAAAMNRYMRAHDVPGRYDEAVARAAEWIVGMQGGDGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSA
RCLSMLCQIGATPGKSEPAARALRYLLAEQMPDGSWFGRWGTNYIYGTWSALCALNATGLAPEAPEMRRAVAWLEQIQNA
DGGWGEDGSSYRLDYRGYEPAPSVASQTAWALLALMAAGAAQHAAVARGIDYLLRTQQSGGLWHEPRFTAVGFPRVFYLR
YHGYARYFPLWALARYRNLQRGGAHQVPWGL

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=654, Percent_Identity=26.7584097859327, Blast_Score=175, Evalue=2e-43,
Organism=Homo sapiens, GI47933395, Length=654, Percent_Identity=26.7584097859327, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI47933397, Length=654, Percent_Identity=26.7584097859327, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI224177556, Length=654, Percent_Identity=25.8409785932722, Blast_Score=154, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321863, Length=158, Percent_Identity=35.4430379746835, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 73789; Mature: 73658

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNETAFATAVPRIAPASAGDSPAPRDAAQALDQGIGRAIDALLHQQRPDGHWVYELEA
CCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
DATIPAEYVLMVHYLGEAPDLELEARLARYLRRIQNPDGGWPLFHEGRSDVSASVKAYFA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEE
LKMAGDDPQAAHMQRARRAVHALGGAEASNVFTRTLLALYGVMPWLAVPMMPVEIMLLPQ
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
WFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRGVGINELFVGNCHTVGLPPRAAHQHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEECCCCCHHHHHCC
GWYTVFRGLDALLRVAEPLVPRTLRRRAIAAAQAFVRERLNGEDGLGAIFPAMANSVMMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEE
DVLGVPPDDPARALARQSVERLLVEHGDEAYCQPCLSPVWDTALAAHALLETGEARATAA
EEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AGRGLDWLRPLQVLDVRGDWAVRRPLVRPGGWAFQYANAYYPDVDDTAVVAAAMNRYMRA
HCCCCHHHCCHHHEECCCCHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
HDVPGRYDEAVARAAEWIVGMQGGDGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVS
CCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
ARCLSMLCQIGATPGKSEPAARALRYLLAEQMPDGSWFGRWGTNYIYGTWSALCALNATG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHCCCC
LAPEAPEMRRAVAWLEQIQNADGGWGEDGSSYRLDYRGYEPAPSVASQTAWALLALMAAG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHC
AAQHAAVARGIDYLLRTQQSGGLWHEPRFTAVGFPRVFYLRYHGYARYFPLWALARYRNL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHH
QRGGAHQVPWGL
HCCCCCCCCCCC
>Mature Secondary Structure 
SMNETAFATAVPRIAPASAGDSPAPRDAAQALDQGIGRAIDALLHQQRPDGHWVYELEA
CCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
DATIPAEYVLMVHYLGEAPDLELEARLARYLRRIQNPDGGWPLFHEGRSDVSASVKAYFA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEE
LKMAGDDPQAAHMQRARRAVHALGGAEASNVFTRTLLALYGVMPWLAVPMMPVEIMLLPQ
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
WFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRGVGINELFVGNCHTVGLPPRAAHQHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEECCCCCHHHHHCC
GWYTVFRGLDALLRVAEPLVPRTLRRRAIAAAQAFVRERLNGEDGLGAIFPAMANSVMMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEE
DVLGVPPDDPARALARQSVERLLVEHGDEAYCQPCLSPVWDTALAAHALLETGEARATAA
EEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AGRGLDWLRPLQVLDVRGDWAVRRPLVRPGGWAFQYANAYYPDVDDTAVVAAAMNRYMRA
HCCCCHHHCCHHHEECCCCHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
HDVPGRYDEAVARAAEWIVGMQGGDGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVS
CCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
ARCLSMLCQIGATPGKSEPAARALRYLLAEQMPDGSWFGRWGTNYIYGTWSALCALNATG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHCCCC
LAPEAPEMRRAVAWLEQIQNADGGWGEDGSSYRLDYRGYEPAPSVASQTAWALLALMAAG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHC
AAQHAAVARGIDYLLRTQQSGGLWHEPRFTAVGFPRVFYLRYHGYARYFPLWALARYRNL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHH
QRGGAHQVPWGL
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]