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The map label for this gene is ispH [H]

Identifier: 116696105

GI number: 116696105

Start: 2456361

End: 2457374

Strand: Direct

Name: ispH [H]

Synonym: H16_B2169

Alternate gene names: 116696105

Gene position: 2456361-2457374 (Clockwise)

Preceding gene: 116696103

Following gene: 116696106

Centisome position: 84.34

GC content: 68.44

Gene sequence:

>1014_bases
ATGCAGGTGATTCTTGCTCAGCCCCGGGGCTTCTGCGCTGGCGTGGTGCGCGCGATCGAGATCGTCGACCGCGCCCTCGT
CAAGCATGGCGCCCCGGTGTTCGTGCGGCATGAGATCGTGCACAACAAGCACGTCGTAGAGGGACTGAAGGACAAGGGGG
CGCGCTTCGTCGAAGAACTGGACGAAGTCCCGACCGGCGCCGTGACGATCTTCAGCGCGCACGGGGTCTCGCGCGAGGTC
ATCGCCGATGCCAGCCAGCGCCAGTTGCATGCCATCGACGCCACCTGCCCGCTGGTGATCAAGGTCCATACCCAGGGCCG
CCAGTACGCGGCCAGCGGCCGCACCGTGATCCTGATCGGCCATGCCGGCCACCCGGAAGTGGAAGGCACCATGGGCCAGA
TCCCGGGCAAGGTGATCCTGGTGCAGAACGAGGCCGAGGTCGCGCAGCTGGACCTGCCCGCCGACACCCCGGTCGCCTAT
GTCACGCAGACCACGCTGAGCGTGGACGACACCCGCAATATCATCGCCGCGCTCGGGCGCCGCTTCAGCAACCTGGTCGG
TCCCGATACGCGCGATATCTGCTACGCCACGCAGAACCGCCAGAGCGCGGTGCGCGACCTGTGCAAGCTGGCCGACGTGA
TCCTGGTGATCGGCGCGACGAACAGCTCCAACTCCAACCGCCTGCGCGAGATCGGCACTGAAAGCGGCGTGCCCAGCTAC
CTGATCGCCGAAGGCGCCGAGCTGGACCCCGCCTGGGTGCGCGACGCCAACGTGGTGGGCATCACCGCCGGCGCCTCCGC
CCCCGAGGAAATGGTCGAGGACGTGATCAACGCGCTGCGCCGGCTGGGCCCGGTGGATGTCACCACCATGGCCGGGCGCG
AGGAACATGCCGAGTTCCGGCTGCCGCCCGAACTGGCCGACGTAAAGCCGCAATCGGCCCCGCGCAAGGCCGGCAAGGAA
CCCGCCGCAGTCGCGGCCGCACCGGCCACCGCCAACGAGAATATCGCCGGCTGA

Upstream 100 bases:

>100_bases
AAATGTGATCTGCGGTGGATCTCCGGTGGATGCCGGTGCATTTCCTGTCCCGCCATCCCAAACACTGAAACCCGTTGCAA
AGGGTCGGGGGGCTTACTCT

Downstream 100 bases:

>100_bases
ACCCAACCAGAGGAAGCTGCCTTGGCTATTCCGCTACTGCAGGTCGCCCGCGTGGGCGCCTACATCGTCGGCAAGCATCT
GTCGCGACAGAAGCGCTATC

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQVILAQPRGFCAGVVRAIEIVDRALVKHGAPVFVRHEIVHNKHVVEGLKDKGARFVEELDEVPTGAVTIFSAHGVSREV
IADASQRQLHAIDATCPLVIKVHTQGRQYAASGRTVILIGHAGHPEVEGTMGQIPGKVILVQNEAEVAQLDLPADTPVAY
VTQTTLSVDDTRNIIAALGRRFSNLVGPDTRDICYATQNRQSAVRDLCKLADVILVIGATNSSNSNRLREIGTESGVPSY
LIAEGAELDPAWVRDANVVGITAGASAPEEMVEDVINALRRLGPVDVTTMAGREEHAEFRLPPELADVKPQSAPRKAGKE
PAAVAAAPATANENIAG

Sequences:

>Translated_337_residues
MQVILAQPRGFCAGVVRAIEIVDRALVKHGAPVFVRHEIVHNKHVVEGLKDKGARFVEELDEVPTGAVTIFSAHGVSREV
IADASQRQLHAIDATCPLVIKVHTQGRQYAASGRTVILIGHAGHPEVEGTMGQIPGKVILVQNEAEVAQLDLPADTPVAY
VTQTTLSVDDTRNIIAALGRRFSNLVGPDTRDICYATQNRQSAVRDLCKLADVILVIGATNSSNSNRLREIGTESGVPSY
LIAEGAELDPAWVRDANVVGITAGASAPEEMVEDVINALRRLGPVDVTTMAGREEHAEFRLPPELADVKPQSAPRKAGKE
PAAVAAAPATANENIAG
>Mature_337_residues
MQVILAQPRGFCAGVVRAIEIVDRALVKHGAPVFVRHEIVHNKHVVEGLKDKGARFVEELDEVPTGAVTIFSAHGVSREV
IADASQRQLHAIDATCPLVIKVHTQGRQYAASGRTVILIGHAGHPEVEGTMGQIPGKVILVQNEAEVAQLDLPADTPVAY
VTQTTLSVDDTRNIIAALGRRFSNLVGPDTRDICYATQNRQSAVRDLCKLADVILVIGATNSSNSNRLREIGTESGVPSY
LIAEGAELDPAWVRDANVVGITAGASAPEEMVEDVINALRRLGPVDVTTMAGREEHAEFRLPPELADVKPQSAPRKAGKE
PAAVAAAPATANENIAG

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=308, Percent_Identity=51.2987012987013, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35825; Mature: 35825

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVILAQPRGFCAGVVRAIEIVDRALVKHGAPVFVRHEIVHNKHVVEGLKDKGARFVEEL
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
DEVPTGAVTIFSAHGVSREVIADASQRQLHAIDATCPLVIKVHTQGRQYAASGRTVILIG
HHCCCCEEEEEECCCCCHHHHHCCHHHHEEEECCCCCEEEEEECCCCEEECCCCEEEEEE
HAGHPEVEGTMGQIPGKVILVQNEAEVAQLDLPADTPVAYVTQTTLSVDDTRNIIAALGR
CCCCCCCCCHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHH
RFSNLVGPDTRDICYATQNRQSAVRDLCKLADVILVIGATNSSNSNRLREIGTESGVPSY
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHCCCCCCCCE
LIAEGAELDPAWVRDANVVGITAGASAPEEMVEDVINALRRLGPVDVTTMAGREEHAEFR
EEECCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
LPPELADVKPQSAPRKAGKEPAAVAAAPATANENIAG
CCCHHHCCCCCCCHHHCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MQVILAQPRGFCAGVVRAIEIVDRALVKHGAPVFVRHEIVHNKHVVEGLKDKGARFVEEL
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
DEVPTGAVTIFSAHGVSREVIADASQRQLHAIDATCPLVIKVHTQGRQYAASGRTVILIG
HHCCCCEEEEEECCCCCHHHHHCCHHHHEEEECCCCCEEEEEECCCCEEECCCCEEEEEE
HAGHPEVEGTMGQIPGKVILVQNEAEVAQLDLPADTPVAYVTQTTLSVDDTRNIIAALGR
CCCCCCCCCHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHH
RFSNLVGPDTRDICYATQNRQSAVRDLCKLADVILVIGATNSSNSNRLREIGTESGVPSY
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHCCCCCCCCE
LIAEGAELDPAWVRDANVVGITAGASAPEEMVEDVINALRRLGPVDVTTMAGREEHAEFR
EEECCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
LPPELADVKPQSAPRKAGKEPAAVAAAPATANENIAG
CCCHHHCCCCCCCHHHCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA