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The map label for this gene is phnW

Identifier: 116695889

GI number: 116695889

Start: 2203957

End: 2205090

Strand: Direct

Name: phnW

Synonym: H16_B1953

Alternate gene names: 116695889

Gene position: 2203957-2205090 (Clockwise)

Preceding gene: 116695888

Following gene: 116695890

Centisome position: 75.67

GC content: 67.99

Gene sequence:

>1134_bases
ATGATTCGCGGCAACGACCCGATCCTTCTGACCCCCGGTCCCCTGACCACCTCGCTCGCCACCAAGCAGGCCATGCTGCG
CGACTGGGGCTCGTGGGACGCCGCCTTCAACGCCATCACGCGCAGCCTGTGCGACGACCTGGTGCGCATCGTCCACGGCG
AAGGCACCCATGTGTGCGTGCCGATGCAGGGCAGCGGCACGTTCTCGGTGGAGGCCGCCATCGCCAACGTGGTGCCGCGC
GACGGCAAGGTGCTGGTGCCGCAGAACGGCGCCTATTGCCAGCGCATCCTCAAGATCTGCAAGGTGCTTGGCCGCGCCAG
CGTGGAACTGCCGATCCCCGAAGACCAGCCCGCCACCGCCGCGCTGATAGAAGAGGCCATCCGGCGCGACCCGTCGATCA
CGCACGTGGCGCAGGTGCACTGCGAGACCGGCGCCGGCGTGCTCAACCCGCTGCAGGAAATCGCCGCGCTGTGCCAGCGG
CTGGGCAAGGGGCTGATCGTCGACGCGATGAGCTCGTTCGGCGCGATCGAGATCGACGCCCGCACCATGCCGTTCGACGC
GCTGGTGGCCGCCACCGGCAAGTGCATCGAGGGCGTGCCGGGCATGGGCTTCGTGCTGGTGAAGAAAGACGTGCTGGAAG
CCAGCCAGGGCAACAGCCACTCGCTGGCGCTGGACCTGTACGACCAGTACGTCTACATGCAGAAGACCACGCAGTGGCGC
TTCACGCCGCCCACGCACGTGGTGGCGGCGTTCCGCACCGCGCTCGACCAGTTCCTGGAAGAAGGCGGCCAGCCGGTGCG
CGGCGCGCGCTACCGCAGGAACTGCGACGCGCTGGTGCAGGGCATGGCCGCACTCGGCTTCCGCGCCTTCCTGCCGGCGG
CGGTGCAGGCGCCGATCATCGTCACCTTCCATGCGCCGGCCGACGCGCGCTATGACTTCAAGACCTTCTACGCCAGGGTG
CGCGAGCGCGGCTACATCCTGTATCCGGGCAAGCTGACGCAGATGGAGACCTTCCGCGTCGGGTGCATTGGTGCGATCGA
CGACAACGAGATGCGCAATGTGGTGACGGCGATTGGCGAGGTGCTGCGCGAGATGGGGATCAAGATGCAGGCGCCGCTGG
CAGAAGCGGCTTGA

Upstream 100 bases:

>100_bases
ACCTGCTGCAACGCGTGCTCGATTGCAAGACCCAGGCCTGGCGCCAGGGCAACGACTGACCTTTCCCCTGTTTCCACTCC
TTCCCAATCAGGAGCTCATC

Downstream 100 bases:

>100_bases
CCCCTTGAGCATCTTCACCTCACTCGCCTAGCAGCAGGCTCCCCTCTCCCGCGAGCGGGAGAGGGGAGCAAACCATCGGT
TCGCAAACTCAACCCTTCAT

Product: 2-aminoethylphosphonate--pyruvate transaminase

Products: NA

Alternate protein names: 2-aminoethylphosphonate aminotransferase; AEP transaminase; AEPT

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITRSLCDDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRASVELPIPEDQPATAALIEEAIRRDPSITHVAQVHCETGAGVLNPLQEIAALCQR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKDVLEASQGNSHSLALDLYDQYVYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGARYRRNCDALVQGMAALGFRAFLPAAVQAPIIVTFHAPADARYDFKTFYARV
RERGYILYPGKLTQMETFRVGCIGAIDDNEMRNVVTAIGEVLREMGIKMQAPLAEAA

Sequences:

>Translated_377_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITRSLCDDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRASVELPIPEDQPATAALIEEAIRRDPSITHVAQVHCETGAGVLNPLQEIAALCQR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKDVLEASQGNSHSLALDLYDQYVYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGARYRRNCDALVQGMAALGFRAFLPAAVQAPIIVTFHAPADARYDFKTFYARV
RERGYILYPGKLTQMETFRVGCIGAIDDNEMRNVVTAIGEVLREMGIKMQAPLAEAA
>Mature_377_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITRSLCDDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRASVELPIPEDQPATAALIEEAIRRDPSITHVAQVHCETGAGVLNPLQEIAALCQR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKDVLEASQGNSHSLALDLYDQYVYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGARYRRNCDALVQGMAALGFRAFLPAAVQAPIIVTFHAPADARYDFKTFYARV
RERGYILYPGKLTQMETFRVGCIGAIDDNEMRNVVTAIGEVLREMGIKMQAPLAEAA

Specific function: Involved in phosphonate degradation

COG id: COG0075

COG function: function code E; Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily

Homologues:

Organism=Homo sapiens, GI4557289, Length=314, Percent_Identity=26.1146496815287, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536281, Length=315, Percent_Identity=22.8571428571429, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHNW_CUPNH (Q0JZT9)

Other databases:

- EMBL:   AM260480
- RefSeq:   YP_841465.1
- ProteinModelPortal:   Q0JZT9
- SMR:   Q0JZT9
- STRING:   Q0JZT9
- GeneID:   4457087
- GenomeReviews:   AM260480_GR
- KEGG:   reh:H16_B1953
- eggNOG:   COG0075
- HOGENOM:   HBG423997
- OMA:   ITHVAQV
- ProtClustDB:   PRK13479
- BioCyc:   REUT381666:H16_B1953-MONOMER
- HAMAP:   MF_01376
- InterPro:   IPR017688
- InterPro:   IPR000192
- InterPro:   IPR012703
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03301
- TIGRFAMs:   TIGR02326

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.37

Molecular weight: Translated: 40914; Mature: 40914

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITRSLCDDLVRIVHGEGTHVCV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
PMQGSGTFSVEAAIANVVPRDGKVLVPQNGAYCQRILKICKVLGRASVELPIPEDQPATA
EECCCCCEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHH
ALIEEAIRRDPSITHVAQVHCETGAGVLNPLQEIAALCQRLGKGLIVDAMSSFGAIEIDA
HHHHHHHHCCCCEEHHEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCEEEEEC
RTMPFDALVAATGKCIEGVPGMGFVLVKKDVLEASQGNSHSLALDLYDQYVYMQKTTQWR
CCCCHHHHHHHCCHHHCCCCCCCEEEEEHHHHHCCCCCCCEEEEEHHHHEEEEEECCCEE
FTPPTHVVAAFRTALDQFLEEGGQPVRGARYRRNCDALVQGMAALGFRAFLPAAVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEE
VTFHAPADARYDFKTFYARVRERGYILYPGKLTQMETFRVGCIGAIDDNEMRNVVTAIGE
EEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
VLREMGIKMQAPLAEAA
HHHHHCCEECCCHHCCC
>Mature Secondary Structure
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITRSLCDDLVRIVHGEGTHVCV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
PMQGSGTFSVEAAIANVVPRDGKVLVPQNGAYCQRILKICKVLGRASVELPIPEDQPATA
EECCCCCEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHH
ALIEEAIRRDPSITHVAQVHCETGAGVLNPLQEIAALCQRLGKGLIVDAMSSFGAIEIDA
HHHHHHHHCCCCEEHHEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCEEEEEC
RTMPFDALVAATGKCIEGVPGMGFVLVKKDVLEASQGNSHSLALDLYDQYVYMQKTTQWR
CCCCHHHHHHHCCHHHCCCCCCCEEEEEHHHHHCCCCCCCEEEEEHHHHEEEEEECCCEE
FTPPTHVVAAFRTALDQFLEEGGQPVRGARYRRNCDALVQGMAALGFRAFLPAAVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEE
VTFHAPADARYDFKTFYARVRERGYILYPGKLTQMETFRVGCIGAIDDNEMRNVVTAIGE
EEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
VLREMGIKMQAPLAEAA
HHHHHCCEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA